Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lisa P. Walker"'
Autor:
Taewan J. Kim, Bruce J. Shenker, Andrew S. MacElroy, Samuel Spradlin, Lisa P. Walker, Kathleen Boesze-Battaglia
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/aa27ab89a8224aadbd65d695a0662335
Aggregatibacter actinomycetemcomitans cytolethal distending toxin modulates host phagocytic function
Autor:
Taewan J. Kim, Bruce J. Shenker, Andrew S. MacElroy, Samuel Spradlin, Lisa P. Walker, Kathleen Boesze-Battaglia
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Cytolethal distending toxins (Cdt) are a family of toxins produced by several human pathogens which infect mucocutaneous tissue and induce inflammatory disease. Human macrophages exposed to Aggregatibacter actinomycetemcomitans (Aa) Cdt respond throu
Externí odkaz:
https://doaj.org/article/a1aa02214b6a4f7587258791a41c72ad
Autor:
Bruce J. Shenker, Jonathan Korostoff, Lisa P. Walker, Ali Zekavat, Anuradha Dhingra, Taewan J. Kim, Kathleen Boesze-Battaglia
Publikováno v:
Pathogens, Vol 13, Iss 2, p 155 (2024)
Recently, we reported that oral-epithelial cells (OE) are unique in their response to Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) in that cell cycle arrest (G2/M) occurs without leading to apoptosis. We now demonstrate tha
Externí odkaz:
https://doaj.org/article/7799e2ad0c1347709122d6bd5c5466d2
Autor:
Grace Huang, Kathleen Boesze-Battaglia, Lisa P. Walker, Ali Zekavat, Zachary P. Schaefer, Steven R. Blanke, Bruce J. Shenker
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Human lymphocytes exposed to Aggregatibacter actinomycetemcomitans (Aa) cytolethal distending toxin (Cdt) undergo cell cycle arrest and apoptosis. In previous studies, we demonstrated that the active Cdt subunit, CdtB, is a potent phosphatidylinosito
Externí odkaz:
https://doaj.org/article/95d2a77b939d4cecaecc0d9e6e8b8f61
Autor:
Kathleen Boesze-Battaglia, Lisa P. Walker, Anuradha Dhingra, Konstantin Kandror, Hsin-Yao Tang, Bruce J. Shenker
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB2 toxin capable of inducing lymphocytes, and other cell types, to undergo cell cycle arrest and apoptosis. Exposure to Cdt results in binding to the cel
Externí odkaz:
https://doaj.org/article/74da68f545e4450d9e22a0fe59218277
Publikováno v:
Pathogens, Vol 9, Iss 1, p 38 (2020)
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB. We now demonstrate that p21CIP1/WAF1 is critical to C
Externí odkaz:
https://doaj.org/article/1a5fa09864d64d578ba997e1383b1db0
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11831
Cytolethal distending toxins (Cdt) are produced by a diverse group of pathogens. One Cdt-producing organism, Aggregatibacter actinomycetemcomitans, plays a critical role in the pathogenesis of a unique form of periodontitis, formerly referred to as l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093771fae7e88d8d751b63b8b74cb604
https://doi.org/10.3390/ijms231911831
https://doi.org/10.3390/ijms231911831
Publikováno v:
Molecular Oral Microbiology. 31:33-42
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces G2 arrest and apoptosis in lymphocytes and other cell types. We have shown that the active subunit, CdtB, exhibits phosphatidylinositol-3,4,5-triphosphate (PIP3) phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b83ee602186109b41f380ff6b38639
https://doi.org/10.1111/omi.12127
https://doi.org/10.1111/omi.12127
Autor:
Bruce J. Shenker, Ali Zekavat, Monika Damek Scuron, Kathleen Boesze-Battaglia, David M. Ojcius, Lisa P. Walker
Publikováno v:
Infection and Immunity. 83:1487-1496
The cytolethal distending toxin (Cdt) is produced from a number of bacteria capable of causing infection and inflammatory disease. Our previous studies with Actinobacillus actinomycetemcomitans Cdt demonstrate not only that the active toxin subunit f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b230eb9e5702bcebac2c01ed12411597
https://doi.org/10.1128/iai.03132-14
https://doi.org/10.1128/iai.03132-14
Autor:
Hsin-Yao Tang, Konstantin V. Kandror, Anuradha Dhingra, Kathleen Boesze-Battaglia, Bruce J. Shenker, Lisa P. Walker
Publikováno v:
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is a heterotrimeric AB2 toxin capable of inducing lymphocytes, and other cell types, to undergo cell cycle arrest and apoptosis. Exposure to Cdt results in binding to the cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d34bc52f80e03adb3236135e54e9d5