CRISPR-Cas knockout of miR21 reduces glioma growth

Autor: Lisa Nieland, Thomas S. van Solinge, Pike See Cheah, Liza M. Morsett, Joseph El Khoury, Joseph I. Rissman, Benjamin P. Kleinstiver, Marike L.D. Broekman, Xandra O. Breakefield, Erik R. Abels

Publikováno v: Molecular Therapy: Oncolytics, Vol 25, Iss , Pp 121-136 (2022)

Non-coding RNAs, including microRNAs (miRNAs), support the progression of glioma. miR-21 is a small, non-coding transcript involved in regulating gene expression in multiple cellular pathways, including the regulation of proliferation. High expressio

Externí odkaz: https://doaj.org/article/e7f869deba594a7dad62253d7bf25498

Engineered EVs designed to target diseases of the CNS

Autor: Lisa Nieland, Shadi Mahjoum, Emily Grandell, Koen Breyne, Xandra O. Breakefield

Publikováno v: Journal of Controlled Release. 356:493-506

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0ce2cd1e832e6901e9afbca193f0d76
https://doi.org/10.1016/j.jconrel.2023.03.009

Advances in local therapy for glioblastoma - taking the fight to the tumour

Autor: Thomas S. van Solinge, Lisa Nieland, E. Antonio Chiocca, Marike L. D. Broekman

Publikováno v: Nature Reviews Neurology, 18(4), 221-236. NATURE PORTFOLIO

Despite advances in neurosurgery, chemotherapy and radiotherapy, glioblastoma remains one of the most treatment-resistant CNS malignancies, and the tumour inevitably recurs. The majority of recurrences appear in or near the resection cavity, usually

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ab37bc352fbd357b7959693dfb9998
https://hdl.handle.net/1887/3570535

Extracellular vesicle-mediated bilateral communication between glioblastoma and astrocytes

Autor: Liza M. Morsett, Lisa Nieland, Erik R. Abels, Xandra O. Breakefield, Marike L. D. Broekman

Publikováno v: Trends Neurosci
Trends in Neurosciences, 44(3), 215-226. ELSEVIER SCIENCE LONDON

Glioblastoma the most aggressive form of brain cancer, comprises a complex mixture of tumor cells and nonmalignant stromal cells, including neurons, astrocytes, microglia, infiltrating monocytes/macrophages, lymphocytes, and other cell types. All non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2349e2a5bf07e0b0ff494ccbb79390e0
https://hdl.handle.net/1887/3196152

Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

Autor: Pike See Cheah, Xandra O. Breakefield, David T. Ting, Zhiyun Wei, Joseph El Khoury, Marike L. D. Broekman, Lisa Nieland, Anna M. Krichevsky, Sybren L. N. Maas, Suzanne E. Hickman, Erik R. Abels, Eric Tai, Sophie A. Dusoswa, Christy Joy Kolsteeg

Publikováno v: Cell reports
Cell Reports, 28(12), 3105
Cell Reports, 28(12), 3105-3119.e7. Cell Press
Abels, E R, Maas, S L N, Nieland, L, Wei, Z, Cheah, P S, Tai, E, Kolsteeg, C-J, Dusoswa, S A, Ting, D T, Hickman, S, el Khoury, J, Krichevsky, A M, Broekman, M L D & Breakefield, X O 2019, ' Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21 ', Cell Reports, vol. 28, no. 12, pp. 3105-3119.e7 . https://doi.org/10.1016/j.celrep.2019.08.036
Cell Reports, 28(12), 3105. Cell Press
Cell Reports, Vol 28, Iss 12, Pp 3105-3119.e7 (2019)

SUMMARY Gliomas are primary, diffusely infiltrating brain tumors. Microglia are innate immune cells in the CNS and make up a substantial portion of the tumor mass. Glioma cells shape their microenvironment, communicating with and reprogramming surrou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33b0ae467e84885707645297c22b621
https://doi.org/10.1016/j.celrep.2019.08.036