Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Lisa Nalbach"'
Autor:
Haopeng Lin, Kunimasa Suzuki, Nancy Smith, Xi Li, Lisa Nalbach, Sonia Fuentes, Aliya F. Spigelman, Xiao-Qing Dai, Austin Bautista, Mourad Ferdaoussi, Saloni Aggarwal, Andrew R. Pepper, Leticia P. Roma, Emmanuel Ampofo, Wen-hong Li, Patrick E. MacDonald
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Pancreatic β-cells respond to metabolic stress by upregulating insulin secretion, however the underlying mechanisms remain unclear. Here we show, in β-cells from overweight humans without diabetes and mice fed a high-fat diet for 2 days, i
Externí odkaz:
https://doaj.org/article/5a3f165b1bd14fb4a4ae1864a4618c3e
Autor:
Selina Wrublewsky, Julia Glas, Christopher Carlein, Lisa Nalbach, Markus Daniel Alexander Hoffmann, Mandy Pack, Eloisa Aparecida Vilas-Boas, Nathan Ribot, Reinhard Kappl, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo, Leticia Prates Roma
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102419- (2022)
Islet transplantation is a promising treatment strategy for type 1 diabetes mellitus (T1DM) patients. However, oxidative stress-induced graft failure due to an insufficient revascularization is a major problem of this therapeutic approach. NADPH oxid
Externí odkaz:
https://doaj.org/article/8c80ec14e87445ed9fb8f66cbec72608
Autor:
Lisa Nalbach, Leticia P Roma, Beate M Schmitt, Vivien Becker, Christina Körbel, Selina Wrublewsky, Mandy Pack, Thomas Später, Wolfgang Metzger, Maximilian M Menger, Florian S Frueh, Claudia Götz, Haopeng Lin, Jocelyn E Manning Fox, Patrick E MacDonald, Michael D Menger, Matthias W Laschke, Emmanuel Ampofo
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 1, Pp 1-21 (2020)
Abstract Pancreatic islet transplantation still represents a promising therapeutic strategy for curative treatment of type 1 diabetes mellitus. However, a limited number of organ donors and insufficient vascularization with islet engraftment failure
Externí odkaz:
https://doaj.org/article/74593c79fb6945478765ddc3d877bb8b
Autor:
Lisa Nalbach, Danièle Müller, Selina Wrublewsky, Wolfgang Metzger, Michael D Menger, Matthias W Laschke, Emmanuel Ampofo
Publikováno v:
Journal of Tissue Engineering, Vol 12 (2021)
Adipose tissue-derived microvascular fragments (MVF) serve as vascularization units in tissue engineering and regenerative medicine. Because a three-dimensional cellular arrangement has been shown to improve cell function, we herein generated for the
Externí odkaz:
https://doaj.org/article/9f6190205e7840328426c2173daec2b1
Autor:
Eloisa A. Vilas-Boas, Christopher Carlein, Lisa Nalbach, Davidson C. Almeida, Emmanuel Ampofo, Angelo R. Carpinelli, Leticia P. Roma, Fernanda Ortis
Publikováno v:
Antioxidants, Vol 10, Iss 8, p 1305 (2021)
In type 1 diabetes (T1D) development, proinflammatory cytokines (PIC) released by immune cells lead to increased reactive oxygen species (ROS) production in β-cells. Nonetheless, the temporality of the events triggered and the role of different ROS
Externí odkaz:
https://doaj.org/article/b169413cbb0347bd9d392b45638c86d9
Autor:
Sarah Spohrer, Rebecca Groß, Lisa Nalbach, Lisa Schwind, Heike Stumpf, Michael D. Menger, Emmanuel Ampofo, Mathias Montenarh, Claudia Götz
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract Glucose homeostasis is regulated by insulin, which is produced in the β-cells of the pancreas. The synthesis of insulin is controlled by several transcription factors including PDX-1, USF1 and USF2. Both, PDX-1 and USF1 were identified as s
Externí odkaz:
https://doaj.org/article/2ec05ada4cd64bb4ab2b9b3d3a635f8d
Autor:
Beate M. Schmitt, Anne S. Boewe, Vivien Becker, Lisa Nalbach, Yuan Gu, Claudia Götz, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo
Publikováno v:
Cells, Vol 9, Iss 6, p 1546 (2020)
Protein kinase CK2 is a crucial regulator of endothelial cell proliferation, migration and sprouting during angiogenesis. However, it is still unknown whether this kinase additionally affects the angiogenic activity of other vessel-associated cells.
Externí odkaz:
https://doaj.org/article/dfa5859fd2574b588add53d13de65493
Publikováno v:
Marine Drugs, Vol 18, Iss 2, p 111 (2020)
Background: The marine-derived triterpenoid frondoside A inhibits the phosphatidylinositol-3-kinase (PI3K) pathway in cancer cells. Because this pathway is also crucially involved in platelet activation, we studied the effect of frondoside A on throm
Externí odkaz:
https://doaj.org/article/a857090e697f47c092fe2064c6fc7c99
Autor:
Michael D. Menger, Anja Scheller, Beate M Schmitt, Emmanuel Ampofo, Lisa Nalbach, Matthias W. Laschke, Vivien Becker
Pancreatic islets are highly vascularized endocrine units. Accordingly, their adequate revascularization is of major importance for successful islet transplantation. The proteoglycan, nerve/glial antigen 2 (NG2) expressed in pericytes is a crucial re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6a37778c400e981c0d186e5fd9fc69
Autor:
Emmanuel Ampofo, Maximilian M Menger, Matthias W. Laschke, Michael D. Menger, Leticia Prates Roma, Lisa Nalbach
Publikováno v:
Acta Diabetologica
Aims The exposure of isolated pancreatic islets to pro-angiogenic factors prior to their transplantation represents a promising strategy to accelerate the revascularization of the grafts. It has been shown that erythropoietin (EPO), a glycoprotein re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8e5f5ac7b02131fb3513f78eee45d9
https://doi.org/10.1007/s00592-021-01760-4
https://doi.org/10.1007/s00592-021-01760-4