Zobrazeno 1 - 3 of 3 pro vyhledávání: '"Lisa N. Toth"'
1
Application of Stable Isotope Methodology in the Evaluation of the Pharmacokinetics of (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Hydrochloride in Rats
Autor: Judith Skaptason, Janice Bower, Emi Kimoto, Timothy G. Heath, David Romero, Lisa N. Toth, Shinji Yamazaki
Publikováno v: Drug Metabolism and Disposition. 37:937-945
The primary objective of this study was to demonstrate the use of stable isotope (SI)-labeled compound as an approach for pharmacokinetic analysis such as fraction absorbed, hepatic extraction ratio, and fraction metabolized from the parent drug to a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8760c60ab32d8b415c1309c1aa18d936
https://doi.org/10.1124/dmd.108.025478
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2
COMPARISON OF PREDICTION METHODS FOR IN VIVO CLEARANCE OF (S,S)-3-[3-(METHYLSULFONYL)PHENYL]-1-PROPYLPIPERIDINE HYDROCHLORIDE, A DOPAMINE D2 RECEPTOR ANTAGONIST, IN HUMANS
Autor: Shinji Yamazaki, Lisa N. Toth, J. Neil Duncan, Meredith L. Black
Publikováno v: Drug Metabolism and Disposition. 32:398-404
The purpose of this study is to investigate reliable prediction methods for in vivo pharmacokinetics and the likelihood of drug interactions with several cytochrome P450 inhibitors in humans for (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d6c6a650ec190d8008c5cd6cb5149e
https://doi.org/10.1124/dmd.32.4.398
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