Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lisa N. Pettingill"'
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18733 (2011)
Exogenous neurotrophin delivery to the deaf cochlea can prevent deafness-induced auditory neuron degeneration, however, we have previously reported that these survival effects are rapidly lost if the treatment stops. In addition, there are concerns t
Externí odkaz:
https://doaj.org/article/825a3e123aa340818143f413e82c0b24
The development of encapsulated cell technologies as therapies for neurological and sensory diseases
Publikováno v:
Journal of Controlled Release. 160:3-13
Cell encapsulation therapies involve the implantation of cells that secrete a therapeutic factor to provide clinical benefits. The transplanted cells are protected from immunorejection via encapsulation in a semipermeable membrane. This treatment str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38f9e60b948f4ac005889ef41a9416a
https://doi.org/10.1016/j.jconrel.2012.01.021
https://doi.org/10.1016/j.jconrel.2012.01.021
Publikováno v:
Neuroscience. 152:821-828
The intracochlear infusion of neurotrophic factors via a mini-osmotic pump has been shown to prevent deafness-induced spiral ganglion neuron (SGN) degeneration; however, the use of pumps may increase the incidence of infection within the cochlea, mak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb039b1b7cfe2a03fbf08d9e8c06ee53
https://doi.org/10.1016/j.neuroscience.2007.11.057
https://doi.org/10.1016/j.neuroscience.2007.11.057
Autor:
Lisa N. Pettingill, Robert K. Shepherd, Stephen O'Leary, Andrew K. Wise, Rachael T. Richardson
Publikováno v:
IEEE Transactions on Biomedical Engineering. 54:1138-1148
Spiral ganglion neurons (SGNs) are the target cells of the cochlear implant, a neural prosthesis designed to provide important auditory cues to severely or profoundly deaf patients. The ongoing degeneration of SGNs that occurs following a sensorineur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05d1fd94df758f5c9b49b380f81b45b
https://doi.org/10.1109/tbme.2007.895375
https://doi.org/10.1109/tbme.2007.895375
Autor:
Stephen J. M. Skinner, Lisa N. Pettingill, Andrew K. Wise, James B Fallon, Robert K. Shepherd, Marilyn S. Geaney, Alison J. Neil
Cochlear implants provide partial restoration of hearing for profoundly deaf patients by electrically stimulating spiral ganglion neurons (SGNs); however, these neurons gradually degenerate following the onset of deafness. Although the exogenous appl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f40a2897672df62db4671d8516fb56
https://europepmc.org/articles/PMC3250292/
https://europepmc.org/articles/PMC3250292/
