Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Lisa N. Chesner"'
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Akademický článek
An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer
Autor: Rajdeep Das, Martin Sjöström, Raunak Shrestha, Christopher Yogodzinski, Emily A. Egusa, Lisa N. Chesner, William S. Chen, Jonathan Chou, Donna K. Dang, Jason T. Swinderman, Alex Ge, Junjie T. Hua, Shaheen Kabir, David A. Quigley, Eric J. Small, Alan Ashworth, Felix Y. Feng, Luke A. Gilbert
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
It is hypothesized that there are a number of tumor specific driver genes for metastatic prostate cancer. Here, the authors perform genome-wide CRISPRi screens and integrate these data with metastatic prostate cancer functional and clinical genomics
Externí odkaz: https://doaj.org/article/fa65632946e846318209a6540b59b6ba
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An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer
Autor: Raunak Shrestha, Eric J. Small, Felix Y. Feng, Jason T. Swinderman, Emily A. Egusa, Rajdeep Das, Alan Ashworth, David A. Quigley, Martin Sjöström, Christopher Yogodzinski, William S. Chen, Donna K. Dang, Junjie Tony Hua, Jonathan Chou, Luke A. Gilbert, Alex Y. Ge, Shaheen Kabir, Lisa N. Chesner
Publikováno v: Nature Communications
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Genomic sequencing of thousands of tumors has revealed many genes associated with specific types of cancer. Similarly, large scale CRISPR functional genomics efforts have mapped genes required for cancer cell proliferation or survival in hundreds of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92f2c224f65522d405b2a937f1bd52e
https://doi.org/10.1038/s41467-021-24919-7
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4
The DNA methylation landscape of advanced prostate cancer
Autor: Karen E. Knudsen, Nupam P. Mahajan, Housheng Hansen He, Martin Sjöström, Kathleen E. Houlahan, Jianhua Luo, S. Laura Chang, Meng Zhang, Kim N. Chi, Paul C. Boutros, Joseph F. Costello, Adam Foye, Denise Playdle, Lawrence Fong, M. Yvonne Kim, Serafim Batzoglou, Martin E. Gleave, Rahul Aggarwal, Li Zhang, Eric D. Chow, Scott A. Tomlins, Felix Y. Feng, Jiaoti Huang, Franklin W. Huang, Hui Li, Haolong Li, George Thomas, Junjie Tony Hua, Irfan A. Asangani, Marc D. Perry, Ha X. Dang, Todd M. Morgan, Robert E. Reiter, Alexander W. Wyatt, Shahneen Sandhu, Amina Zoubeidi, Christopher G. Maher, Daniel E. Spratt, Tanushree R. Shenoy, Luke A. Gilbert, Arul M. Chinnaiyan, Joshi J. Alumkal, Scott M. Dehm, Phillip G. Febbo, Primo N. Lara, Tomasz M. Beer, Adina M. Bailey, Rajdeep Das, Owen N. Witte, Alan Ashworth, Lisa N. Chesner, Joshua M. Lang, Mohammed Alshalalfa, Eric J. Small, Rohit Bose, Wilbert Zwart, David A. Quigley, Christopher P. Evans, Arnold Liao, Shuang G. Zhao, Yu Jia Shiah, Kyle Kai-How Farh, Hani Goodarzi, Travis J. Barnard, William S. Chen, Rendong Yang, Jonathan Chou, Ruhollah Moussavi-Baygi, Matthew Rettig
Publikováno v: Nature genetics
Nature genetics, vol 52, iss 8
Although DNA methylation is a key regulator of gene expression, the comprehensive methylation landscape of metastatic cancer has never been defined. Through whole-genome bisulfite sequencing paired with deep whole-genome and transcriptome sequencing
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76e9da3c06333592aa417976e6aa5a6
https://pubmed.ncbi.nlm.nih.gov/32661416
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DNA-protein crosslinks are repaired via homologous recombination in mammalian mitochondria
Autor: Cecilia Warner, Lisa N. Chesner, Maram M. Essawy, Colin R Campbell
Publikováno v: DNA repair
While mammalian mitochondria are known to possess a robust base excision repair system, direct evidence for the existence of additional mitochondrial DNA repair pathways is elusive. Herein a PCR-based assay was employed to demonstrate that plasmids c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52af89348a953684957d351605bb5c86
https://doi.org/10.1016/j.dnarep.2020.103026
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A Simple, Rapid, and Quantitative Assay to Measure Repair of DNA-protein Crosslinks on Plasmids Transfected into Mammalian Cells
Autor: Colin R Campbell, Lisa N. Chesner
Publikováno v: Journal of Visualized Experiments : JoVE
The purpose of this method is to provide a flexible, rapid, and quantitative technique to examine the kinetics of DNA-protein crosslink (DPC) repair in mammalian cell lines. Rather than globally assaying removal of xenobiotic-induced or spontaneous c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69741cba03e74469e849acffec9144fb
https://doi.org/10.3791/57413
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7
A quantitative PCR-based assay reveals that nucleotide excision repair plays a predominant role in the removal of DNA-protein crosslinks from plasmids transfected into mammalian cells
Autor: Colin R Campbell, Lisa N. Chesner
Publikováno v: DNA repair. 62
DNA-protein crosslinks (DPCs) are complex DNA lesions that induce mutagenesis and cell death. DPCs are created by common antitumor drugs, reactive oxygen species, and endogenous aldehydes. Since these agents create other types of DNA damage in additi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b336b3acd9a87b76b24b1365d7d05f10
https://pubmed.ncbi.nlm.nih.gov/29413806
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8
Cellular Repair of DNA–DNA Cross-Links Induced by 1,2,3,4-Diepoxybutane
Autor: Bhaskar Malayappan, Amanda Degner, Colin R Campbell, Shira Yomtoubian, Lisa N. Chesner, Dewakar Sangaraju, Natalia Y. Tretyakova, Susith Wickramaratne
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 5, p 1086 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 5; Pages: 1086
Xenobiotic-induced interstrand DNA–DNA cross-links (ICL) interfere with transcription and replication and can be converted to toxic DNA double strand breaks. In this work, we investigated cellular responses to 1,4-bis-(guan-7-yl)-2,3-butanediol (bi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817d0f03693340f8d5cc463c8e1b52dd
https://doi.org/10.3390/ijms18051086
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