Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lisa N, Putral"'
Autor:
Hsin-I Chang, Sherry Y. Wu, Mingtao Liang, Lisa N. Putral, Nigel M. Davies, Nigel A.J. McMillan
Publikováno v:
Pharmaceutical Research. 26:512-522
A simple yet novel method was developed to prepare stable PEGylated siRNA-loaded lipid particles which are suitable for in vivo use. PEGylated siRNA-loaded lipid particles were formulated by hydration of a freeze-dried matrix. The effect of various f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d264d563e27e564cf3a457d90116b3af
https://doi.org/10.1007/s11095-008-9766-1
https://doi.org/10.1007/s11095-008-9766-1
Autor:
Nicholas A. Saunders, Lisa N. Putral, Nigel A.J. McMillan, Wenyi Gu, Graham R. Leggatt, K Minto, Kylie Hengst
Publikováno v:
Cancer Gene Therapy. 13:1023-1032
In this study, we investigated the suppressive effect of a short hairpin RNA delivered by a lentiviral vector (LV-shRNA) against human papillomavirus (HPV) type 18 E6 on the expression of the oncogenes E6 and E7 in cervical cancer HeLa cells both in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888b85123abbef556dacbd53b44907c3
https://doi.org/10.1038/sj.cgt.7700971
https://doi.org/10.1038/sj.cgt.7700971
Autor:
Nigel A.J. McMillan, Akul Singhania, Sherry Y. Wu, Nigel M. Davies, Lisa N. Putral, Carl M. J. Kirkpatrick, Melinda Burgess
Publikováno v:
Gene therapy. 18(1)
Small interfering RNA (siRNA) shows great promise in cancer therapy, but its effectiveness in vivo still remains a crucial issue for its transition into the clinics. Although the successful use of polyethylene glycol (PEG)ylated lipidic delivery syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d514411938dd14c03762bc76c282a446
https://pubmed.ncbi.nlm.nih.gov/20703312
https://pubmed.ncbi.nlm.nih.gov/20703312
Publikováno v:
Methods in Molecular Biology™ ISBN: 9781588298744
We describe the protocols of using siRNAs, or shRNAs delivered by a lentiviral vector, as a means to silence cancer-causing genes. We use cervical cancer as a model to demonstrate the inhibition of the human papillomavirus (HPV) oncogenes E6 and E7 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::054c89a4a0019e10a21b4e1a3992e570
https://doi.org/10.1007/978-1-59745-191-8_12
https://doi.org/10.1007/978-1-59745-191-8_12
Publikováno v:
Current opinion in molecular therapeutics. 9(2)
Cervical cancer is an attractive model in which to test gene-specific therapies, because elimination of the HPV oncogenes E6 and E7 may result in cancer cell senescence. Oligonucleotide-based therapies tested over the years include antisense oligonuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66726d135c3a27aa2b21045ea2355c50
https://pubmed.ncbi.nlm.nih.gov/17458165
https://pubmed.ncbi.nlm.nih.gov/17458165