Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lisa Molz"'
Autor:
Sarah J. Mahoney, Sridhar Narayan, Lisa Molz, Lauren A. Berstler, Seong A. Kang, George P. Vlasuk, Eddine Saiah
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Aberrant mTORC1 signaling is linked to several chronic diseases. Here, the authors develop a small molecule inhibitor that binds the small G-protein Rheb and selectively blocks mTORC1 signaling, holding potential for therapeutic applications.
Externí odkaz:
https://doaj.org/article/e4e93d6c676242c793f6e0e9b9280186
Autor:
Bruce Follows, Shawn Fessler, Timm Baumeister, Ann-Marie Campbell, Mary Margaret Zablocki, Hongbin Li, Deepali Gotur, Zhongguo Wang, Xiaozhang Zheng, Lisa Molz, Cokey Nguyen, Torsten Herbertz, Liann Wang, Kenneth Bair
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2375-2382
Mcl-1 is an anti-apoptotic protein overexpressed in hematological malignancies and several human solid tumors. Small molecule inhibition of Mcl-1 would offer an effective therapy to Mcl-1 mediated resistance. Subsequently, it has been the target of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c397dc7a19ede1383733b944a5d0534
https://doi.org/10.1016/j.bmcl.2019.06.008
https://doi.org/10.1016/j.bmcl.2019.06.008
Autor:
Lauren A. Berstler, Sarah J. Mahoney, George P. Vlasuk, Sridhar Narayan, Eddine Saiah, Seong A. Kang, Lisa Molz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
The small G-protein Rheb activates the mechanistic target of rapamycin complex 1 (mTORC1) in response to growth factor signals. mTORC1 is a master regulator of cellular growth and metabolism; aberrant mTORC1 signaling is associated with fibrotic, met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79821839bb734d9a67167aa43008928e
https://doi.org/10.1038/s41467-018-03035-z
https://doi.org/10.1038/s41467-018-03035-z
Autor:
Eddine Saiah, George P. Vlasuk, Seong A. Kang, Stephanie N. Galda, Shomit Sengupta, Jessica J. Howell, Lisa Molz, David John O'neill, Sarah J. Mahoney, Andreas W. Machl, Seung Hahm, Casey J. Lumpkin
Publikováno v:
Cell Chemical Biology. 26:1203-1213.e13
Summary The mechanistic target of rapamycin (mTOR) is a central regulator of cellular metabolic processes. Dysregulation of this kinase complex can result in a variety of human diseases. Rapamycin and its analogs target mTORC1 directly; however, chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e4e82f2a630644712668cbd876df78
https://doi.org/10.1016/j.chembiol.2019.05.009
https://doi.org/10.1016/j.chembiol.2019.05.009
Autor:
Sam Lievens, Maureen Caligiuri, Jan Tavernier, Faith Kaplan, Nikolai Kley, Lisa Molz, Jimmy P. Xu, Jiangwen Z. Majeti, Krishna K. Murthi, Rebeca Ramos-Kelsey, Qing Liu
Publikováno v:
Chemistry & Biology. 13:711-722
SummaryOrganic small molecules generally act by perturbing the function of one or more cellular target proteins, the identification of which is essential to an understanding of the molecular basis of drug action. Here we describe the application of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247e3727196ef802488756f5485c13ed
https://doi.org/10.1016/j.chembiol.2006.05.008
https://doi.org/10.1016/j.chembiol.2006.05.008
Publikováno v:
Journal of Biological Chemistry. 271:13892-13899
We report the identification of a novel class of phosphatidylinositol (PtdIns) 3-kinases whose members contain C-terminal C2 domains. We have isolated Drosophila and murine genes (termed cpk and cpk-m respectively) by polymerase chain reaction amplif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439ca1da3678482f753fb3a8afc5ca05
https://doi.org/10.1074/jbc.271.23.13892
https://doi.org/10.1074/jbc.271.23.13892