Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lisa Michelle, Restelli"'
Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer’s disease
Autor:
Barbara Bettegazzi, Laura Sebastian Monasor, Serena Bellani, Franca Codazzi, Lisa Michelle Restelli, Alessio Vittorio Colombo, Nikolaus Deigendesch, Stephan Frank, Takashi Saito, Takaomi C. Saido, Sven Lammich, Sabina Tahirovic, Fabio Grohovaz, Daniele Zacchetti
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-14 (2021)
Abstract Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder. Increased Aβ production plays a fundamental role in the pathogenesis of the disease and BACE1, the protease that triggers the amyloidogenic processing of
Externí odkaz:
https://doaj.org/article/0432a5c706c549658e2f87056cfe8f8a
Autor:
Lisa Michelle Restelli, Björn Oettinghaus, Mark Halliday, Cavit Agca, Maria Licci, Lara Sironi, Claudia Savoia, Jürgen Hench, Markus Tolnay, Albert Neutzner, Alexander Schmidt, Anne Eckert, Giovanna Mallucci, Luca Scorrano, Stephan Frank
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1407-1414 (2018)
Summary: Stress adaptation is essential for neuronal health. While the fundamental role of mitochondria in neuronal development has been demonstrated, it is still not clear how adult neurons respond to alterations in mitochondrial function and how ne
Externí odkaz:
https://doaj.org/article/670823978c0c43279bed4d9801aac41c
Publikováno v:
Cells, Vol 9, Iss 1, p 233 (2020)
The pathogenesis of Parkinson’s disease (PD), the second most common neurodegenerative disorder, is complex and involves the impairment of crucial intracellular physiological processes. Importantly, in addition to abnormal α-synuclein aggregation,
Externí odkaz:
https://doaj.org/article/f71bdf935cbb4fb18b1438e49bb4b651
Autor:
David P. Wolfer, Dimitri Shcherbakov, Anne Eckert, Martina Nigri, Kader Thiam, James M. Moore, Rashid Akbergenov, Patricia Isnard-Petit, Stephan Frank, Amandine Grimm, Lisa Michelle Restelli, Petra Seebeck, Erik C. Böttger
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Communications Biology, 4 (1)
Communications Biology
Communications Biology, 4 (1)
Communications Biology
Random errors in protein synthesis are prevalent and ubiquitous, yet their effect on organismal health has remained enigmatic for over five decades. Here, we studied whether mice carrying the ribosomal ambiguity (ram) mutation Rps2-A226Y, recently sh
Publikováno v:
Cells, Vol 9, Iss 1, p 233 (2020)
Cells
Cells
The pathogenesis of Parkinson’s disease (PD), the second most common neurodegenerative disorder, is complex and involves the impairment of crucial intracellular physiological processes. Importantly, in addition to abnormal α-synuclein aggregation,
Autor:
Claudia Savoia, Jürgen Hench, Maria Licci, Lisa Michelle Restelli, Luca Scorrano, Giovanna R. Mallucci, Mark Halliday, Markus Tolnay, Albert Neutzner, Cavit Agca, Lara Sironi, Björn Oettinghaus, Stephan Frank, Anne Eckert, Alexander Schmidt
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1407-1414 (2018)
Cell Reports
Cell Reports
Summary Stress adaptation is essential for neuronal health. While the fundamental role of mitochondria in neuronal development has been demonstrated, it is still not clear how adult neurons respond to alterations in mitochondrial function and how neu
Autor:
Barbara, Bettegazzi, Ilaria, Pelizzoni, Floramarida, Salerno Scarzella, Lisa Michelle, Restelli, Daniele, Zacchetti, Francesca, Maltecca, Giorgio, Casari, Fabio, Grohovaz, Franca, Codazzi
Publikováno v:
Oxidative Medicine and Cellular Longevity
Several neurodegenerative disorders exhibit selective vulnerability, with subsets of neurons more affected than others, possibly because of the high expression of an altered gene or the presence of particular features that make them more susceptible
Autor:
Franca Codazzi, Barbara Bettegazzi, Fabio Grohovaz, Francesca Maltecca, Ilaria Pelizzoni, Lisa Michelle Restelli, Daniele Zacchetti, Giorgio Casari, Floramarida Salerno Scarzella
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Several neurodegenerative disorders exhibit selective vulnerability, with subsets of neurons more affected than others, possibly because of the high expression of an altered gene or the presence of particular features that make them more susceptible
Autor:
Maria Licci, Luca Scorrano, Markus Tolnay, Lisa Michelle Restelli, Claudia Savoia, Donato D'Alonzo, Elisa Barbieri, Björn Oettinghaus, Stephan Frank
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1857:1267-1276
During apoptosis mitochondria undergo cristae remodeling and fragmentation, but how the latter relates to outer membrane permeabilization and downstream caspase activation is unclear. Here we show that the mitochondrial fission protein Dynamin Relate
Autor:
Naotada Ishihara, Robert Dallmann, Anne Eckert, Karen Schmitt, Jürgen A. Ripperger, Stephan Frank, Steven A. Brown, Katsuyoshi Mihara, Urs Albrecht, Amandine Grimm, Melissa Witzig, Bjoern Oettinghaus, Lisa Michelle Restelli
Mitochondrial fission-fusion dynamics and mitochondrial bioenergetics, including oxidative phosphorylation and generation of ATP, are strongly clock controlled. Here we show that these circadian oscillations depend on circadian modification of dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3305a0746d05e00cd466302415edf0b9
https://doi.org/10.5167/uzh-156990
https://doi.org/10.5167/uzh-156990