Delivery of a novel intervention to facilitate liberation from mechanical ventilation in paediatric intensive care: A process evaluation.

Autor: Joanne Jordan, Lyvonne Tume, Mike Clarke, Danny McAuley, Cliona McDowell, Lisa McIlmurray, Kevin Morris, Mark Peters, Timothy Walsh, Bronagh Blackwood

Publikováno v: PLoS ONE, Vol 18, Iss 11, p e0293063 (2023)

BackgroundProlonged mechanical ventilation increases the risk of mortality and morbidity. Optimising sedation and early testing for possible liberation from invasive mechanical ventilation (IMV) has been shown to reduce time on the ventilator. Alongs

Externí odkaz: https://doaj.org/article/22df0649f8a94f9db54dc126498072e1

Co-ordinated multidisciplinary intervention to reduce time to successful extubation for children on mechanical ventilation: the SANDWICH cluster stepped-wedge RCT

Autor: Bronagh Blackwood, Kevin P Morris, Joanne Jordan, Lisa McIlmurray, Ashley Agus, Roisin Boyle, Mike Clarke, Christina Easter, Richard G Feltbower, Karla Hemming, Duncan Macrae, Clíona McDowell, Margaret Murray, Roger Parslow, Mark J Peters, Glenn Phair, Lyvonne N Tume, Timothy S Walsh, Daniel F McAuley

Publikováno v: Health Technology Assessment, Vol 26, Iss 18 (2022)

Background: Daily assessment of patient readiness for liberation from invasive mechanical ventilation can reduce the duration of ventilation. However, there is uncertainty about the effectiveness of this in a paediatric population. Objectives: To det

Externí odkaz: https://doaj.org/article/7eebbd3065c04edd9304d6d46a5a0e22

Effect of a Sedation and Ventilator Liberation Protocol vs Usual Care on Duration of Invasive Mechanical Ventilation in Pediatric Intensive Care Units: A Randomized Clinical Trial

Autor: Joanne Jordan, Richard G. Feltbower, Karla Hemming, Ashley Agus, Cliona McDowell, Mark J. Peters, Margaret Murray, Lisa McIlmurray, Daniel F. McAuley, Bronagh Blackwood, Duncan Macrae, Christina Easter, Roger C Parslow, Timothy S. Walsh, Mike Clarke, Lyvonne N Tume, Kevin P Morris

Publikováno v: JAMA
Blackwood, B, Tume, L N, Morris, K P, Clarke, M, McDowell, C, Hemming, K, Peters, M J, McIlmurray, L, Jordan, J, Agus, A, Murray, M, Parslow, R, Walsh, T S, Macrae, D, Easter, C, Feltbower, R G & McAuley, D F 2021, ' Effect of a sedation and ventilator liberation protocol vs usual care on duration of invasive mechanical ventilation in pediatric intensive care units : a randomized clinical trial ', Journal of the American Medical Association, vol. 326, no. 5, pp. 401-410 . https://doi.org/10.1001/jama.2021.10296

Importance There is limited evidence on the optimal strategy for liberating infants and children from invasive mechanical ventilation in the pediatric intensive care unit.Objective To determine if a sedation and ventilator liberation protocol interve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee3567dc926e28e7e79aeb6d30136e2

rhBMP-2, rhVEGF165, rhPTN and thrombin-related peptide, TP508 induce chemotaxis of human osteoblasts and microvascular endothelial cells

Autor: Lisa McIlmurray, Gang Li, William E. Allen, Hali Wang, Yuxin Cui

Publikováno v: Journal of Orthopaedic Research. 23:680-685

Osteogenesis and angiogenesis are inter-linked and tightly regulated processes involved in growth, repair, and bone remodeling. Bone morphogenic protein 2 (BMP-2), vascular endothelial growth factor (VEGF), pleiotrophin (PTN) and thrombin-related pep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c40b1bc1b12d172049977c340ad095
https://doi.org/10.1016/j.orthres.2004.12.005