Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lisa Marie Thomasco"'
Autor:
James Robert Blinn, Dean L. Shinabarger, Jerry R. Colca, Lisa Marie Thomasco, Steven Swaney, Alexander S. Mankin, Liqun Xiong, William G. McDonald, Karen L. Leach, Robert C. Gadwood
Publikováno v:
Molecular Cell. 26(3):393-402
The oxazolidinones are one of the newest classes of antibiotics. They inhibit bacterial growth by interfering with protein synthesis. The mechanism of oxazolidinone action and the precise location of the drug binding site in the ribosome are unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229195b2d3a6e5954eff13c844810e48
Autor:
William G. McDonald, Alexander S. Mankin, Dean L. Shinabarger, Liqun Xiong, Eric T. Lund, Jerry R. Colca, James D. Pearson, Lonnie D. Adams, John E. Mott, Eric T. Cecil, Gregory S. Cavey, Daniel J. Waldon, W. Rodney Mathews, Lisa Marie Thomasco, Jeffrey H. Bock, Robert C. Gadwood
Publikováno v:
Journal of Biological Chemistry. 278:21972-21979
Oxazolidinone antibiotics, an important new class of synthetic antibacterials, inhibit protein synthesis by interfering with ribosomal function. The exact site and mechanism of oxazolidinone action has not been elucidated. Although genetic data point
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16377689cfa93ac00956916876aa9e75
https://doi.org/10.1074/jbc.m302109200
https://doi.org/10.1074/jbc.m302109200
Autor:
Lilli Ann Wolf-Gouveia, Paul D. Lira, Eric B. McElroy, Lisa Marie Thomasco, Matthew Frank Brown, Christopher S. Jones, Jonathan L. Doty, Lawrence A. Reiter, Sandra P. McCurdy, Anthony Marfat, Sharon L. Ripp, Mark J. Mitton-Fry, William H. Brissette, Andrei Shavnya, Linde Robert Gerald, Thomas M. Harris, Kristen A. Trevena, Qifang Li, Laura Cook Blumberg, Amy S. Antipas, James P. Driscoll, Michael John Munchhof, Jeffrey M. Casavant
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1428-1430
Recently, we disclosed a series of potent pyrimidine benzamide-based thrombopoietin receptor agonists. Unfortunately, the structural features required for the desired activity conferred physicochemical properties that were not favorable for the devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c13f353a20302d8bc86c0f3e090d44
https://doi.org/10.1016/j.bmcl.2009.01.032
https://doi.org/10.1016/j.bmcl.2009.01.032
Autor:
Kevin J Stefanski, Allen E. Buhl, Heinrich J. Schostarez, Bharat V. Kamdar, Marshall N. Brunden, Lisa Marie Thomasco, Garland A. Johnson, Kathy L. Shull, Daniel J. Waldon, Randall G. Stehle, A. R. Diani, Michael J. Mulholland, Theresa M. Schwartz, Steven J. Conrad, Robert C. Gadwood, Marc F. Kubicek
Publikováno v:
Journal of Investigative Dermatology. 98:315-319
The opening of intracellular potassium channels has been suggested as a mechanism regulating hair growth. Enhancing the flux of potassium ions is a mechanism shared by several structurally diverse antihypertensive agents including minoxidil sulfate (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c37d9c08572de8fad1039b8845b74a
https://doi.org/10.1111/1523-1747.ep12499788
https://doi.org/10.1111/1523-1747.ep12499788
Autor:
Diana Sperger, Laura Cook Blumberg, Emilio J. Mangual, Kristen A. Trevena, Christopher S. Jones, Jonathan L. Doty, Fangning Zhang, William H. Brissette, Marc I. Smeets, Qifang Li, Paul D. Lira, Amy S. Antipas, Lilli Ann Wolf-Gouveia, Sandra P. McCurdy, Lisa Marie Thomasco, Andrei Shavnya, Sharon L. Ripp, Richard M. Shepard, Liling Zhang, Chakrapani Subramanyam, Linde Robert Gerald, Michael John Munchhof, Lawrence A. Reiter, James P. Driscoll
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(19)
A series of pyrimidine benzamide-based thrombopoietin receptor agonists is described. The lead molecule contains a 2-amino-5-unsubstituted thiazole, a group that has been associated with idiosyncratic toxicity. The potential for metabolic oxidation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28920ad58a16caa053bbc11c89c4ece
https://pubmed.ncbi.nlm.nih.gov/17707640
https://pubmed.ncbi.nlm.nih.gov/17707640
Autor:
Betty H. Yagi, Ronda D. Schaadt, Gary E. Zurenko, Judith C. Hamel, Judy K. Moerman, Jason M. Ochoada, Lisa Marie Thomasco, Douglas Stapert, Elizabeth A. Weaver, Ford Charles W, Robert C. Gadwood
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(23)
Replacement of the morpholine C-ring of linezolid 1 with a 1,3,4-thiadiazolyl ring leads to oxazolidinone analogues 5 having potent antibacterial activity against both gram-positive and gram-negative organisms. Conversion of the C5 acetamide group to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99b494012e2c87b63a7399d59c99102
https://pubmed.ncbi.nlm.nih.gov/14622999
https://pubmed.ncbi.nlm.nih.gov/14622999
Autor:
Hiromi Yamada, Kiyotaka Munesada, Lisa Marie Thomasco, Mikio Taniguchi, Ford Charles W, Hutchinson Douglas K, Gary E. Zurenko, Steven J. Brickner, Kevin C. Grega, Robert C. Gadwood, Barbachyn Michael R, Toops Dana S, Stuart A. Garmon, Robert J. Reischer
Publikováno v:
Resolving the Antibiotic Paradox ISBN: 9781461372202
Throughout the human experience, diseases caused by pathogenic bacteria have exerted an enormous negative impact on society. Today, for example, approximately one third of the world’s population is infected with Mycobacterium tuberculosis and tuber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85c8b713027d58393afa21662f7e764d
https://doi.org/10.1007/978-1-4615-4897-3_12
https://doi.org/10.1007/978-1-4615-4897-3_12
