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Publikováno v:
Current protocols in stem cell biologyLiterature Cited. 52(1)
TP53 point mutations are found in 50% of all cancers and seem to play an important role in cancer pathogenesis. Thus, human induced pluripotent stem cells (hiPSCs) overexpressing mutant TP53 are a valuable tool for the generation of in vitro models o
Autor:
Daniel Hein, David Pauck, Marc Remke, Gabriel Leprivier, Thorsten Rosenbaum, Heinz Ahlert, Nan Qin, Cyrill Schipp, Arndt Borkhardt, Ute Fischer, Bianca Killing, Lisa Maria Kuhn, Jonathan K M Lim, Sanil Bhatia, Vera H Jepsen, Kai Völtzke, Jasmin Bartl, Viktoria Marquardt
Publikováno v:
Blood. 134:4651-4651
Juvenile myelomonocytic leukemia (JMML) is a chronic, poor prognostic myeloid neoplasm of childhood that is characterized by malignant expansion of monocytic cells. Chemo- and radiotherapy are not effective in JMML, therefore allogeneic hematopoietic