Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lisa M. Swanson"'
Autor:
Dongwoo Shin, Arun K. Ghosh, Louis E. Holland, K. Krishnan, Jim Buthod, Lisa M. Swanson, D. Eric Walters, Hanna Cho, Khaja Azhar Hussain
Publikováno v:
Il Farmaco. 56:29-32
A number of structurally novel P2-ligands have been designed and synthesized. Incorporation of these ligands in the (R)-(hydroxyethyl)sulfonamide isostere provided a series of potent non-peptidyl HIV protease inhibitors.
Autor:
Dongwoo Shin, K. Krishnan, Hanna Cho, Louis E. Holland, Lisa M. Swanson, Khaja Azhar Hussain, Jim Buthod, Arun K. Ghosh, D. Eric Walters
Publikováno v:
ChemInform. 32
A number of structurally novel P2-ligands have been designed and synthesized. Incorporation of these ligands in the (R)-(hydroxyethyl)sulfonamide isostere provided a series of potent non-peptidyl HIV protease inhibitors.
Autor:
Lisa M. Swanson, Louis E. Holland, Jim Buthod, Chunfeng Liu, Hanna Cho, Arun K. Ghosh, Khaja Azhar Hussain, D. Eric Walters
Publikováno v:
ChemInform. 33
A series of novel macrocyclic urethanes incorporating a (R)-hydroxyethylamine isostere was designed and synthesized. Ring size and substituent efffects have been investigated. Cyclourethanes containing 14- to 16-membered rings exhibited low nanomolar
Autor:
Yasuhiro Koh, Arun K. Ghosh, Hanna Cho, D. Eric Walters, Lisa M. Swanson, Sofiya Leshchenko, Stephanie Kay, Hiroaki Mitsuya, Khaja Azhar Hussain
Publikováno v:
Journal of medicinal chemistry. 48(10)
The structure-based design and synthesis of a series of novel nonpeptide HIV protease inhibitors are described. The inhibitors were designed based upon the X-ray crystal structure of inhibitor 1 (UIC-94017)-bound HIV-1 protease. The inhibitors incorp
Autor:
Arun K. Ghosh, Lisa M. Swanson
Publikováno v:
ChemInform. 35
Autor:
Lisa M. Swanson, Arun K. Ghosh
Publikováno v:
The Journal of organic chemistry. 68(25)
A highly enantioselective and convergent synthesis of cryptophycin 52 (2), an exceedingly potent cytotoxic agent, is described. Cryptophycin 52, a synthetic variant of the cryptophycin family, is currently undergoing clinical trials. The synthesis is
Novel cyclourethane-derived HIV protease inhibitors: a ring-closing olefin metathesis based strategy
Autor:
D. Eric Walters, Lisa M. Swanson, Chunfeng Liu, Hanna Cho, Khaja Azhar Hussain, Jim Buthod, Arun K. Ghosh, Louis E. Holland
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(15)
A series of novel macrocyclic urethanes incorporating a (R)-hydroxyethylamine isostere was designed and synthesized. Ring size and substituent efffects have been investigated. Cyclourethanes containing 14- to 16-membered rings exhibited low nanomolar