Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

Autor: Jay M. Sosenko, D. J. Becker, Kevan C. Herold, E. Leschek, James W. Thomas, Francesco Dotta, Jeffrey L. Mahon, K. Nanto-Salonen, Diane K. Wherrett, Lisa M. Spain, Andrew Muir, Polly J. Bingley, Massimo Trucco, Jeffrey P. Krischer, S. E. Gitelman, Alessandra Mandelli, Mark S. Anderson, Sarah J. Richardson, Peter S. Linsley, Riccardo Bonfanti, Eleonora Bianconi, George S. Eisenbarth, M. Siegelman, J. Peyman, Angela Stabilini, M. Redondo, Bernhard J. Hering, Richard A. Insel, Maurizio De Pellegrin, Franco Meschi, Francesca Ragogna, Mark A. Clements, Lars Krogvold, Mark Peakman, Alberto Pugliese, J. Blum, William E. Russell, P. Chase, Pia Leete, Anette-Gabriele Ziegler, Mark A. Atkinson, Jane H. Buckner, Andrea Rigamonti, Tihamer Orban, Laura Nigi, Philip Raskin, Guido Sebastiani, Louis H. Philipson, Linda A. DiMeglio, Clara Bonura, Manuela Battaglia, Jay S. Skyler, David A. Baidal, Giulio Frontino, Emanuele Bosi, Matthew J. Dufort, Andrea Valle, William E. Winter, Peter A. Gottlieb, C. G. Fathman, Helena Elding Larsson, Robin Goland, Michael J. Clare-Salzler, M. G. Roncarolo, Raphael Clynes, Peter A. Antinozzi, Andrea K. Steck, Mikael Knip, Olli Simell, R. Parkman, Bart O. Roep, Desmond A. Schatz, Henry Rodriguez, Nicola Lo Buono, John M. Wentworth, Andrea Laurenzi, Francesca Mancarella, P. Savage, Jennifer B. Marks, G. Grave, Paola M.V. Rancoita, Federica Vecchio, Åke Lernmark, Darrell M. Wilson, Noel G. Morgan, Thomas W.H. Kay, Francine R. Kaufman, Federica Cugnata, Christophe Benoist, Susan Geyer, Peter G. Colman, Mark D. Pescovitz, Robert S. Sherwin, Gerald T. Nepom, John E. Wagner, Antoinette Moran, Knut Dahl-Jørgensen, Jerry P. Palmer, Kasia Bourcier, Wayne V. Moore, Carla J. Greenbaum, Pauline Grogan

BACKGROUND. Neutrophils and their inflammatory mediators are key pathogenic components in multiple autoimmune diseases, while their role in human type 1 diabetes (T1D), a disease that progresses sequentially through identifiable stages prior to the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee5d8b12a49d70a6a58dc2174c69799

Effects of Exenatide Alone and in Combination With Daclizumab on β-Cell Function in Long-Standing Type 1 Diabetes

Autor: Benigno J. Digon, Lisa M. Spain, David M. Harlan, Michael Ring, Kristina I. Rother, Jerry P. Palmer, H.-Michael Dosch, Kim Chen, Patric Nelson, Robert Wesley, Barbara Brooks-Worrell, Alain D. Baron

Publikováno v: Diabetes Care

OBJECTIVE In patients with long-standing type 1 diabetes, we investigated whether improved β-cell function can be achieved by combining intensive insulin therapy with agents that may 1) promote β-cell growth and/or limit β-cell apoptosis and 2) we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672ca995665c24c32f205e9c5375eee5
https://doi.org/10.2337/dc09-0773

TLX1/HOX11-mediated disruption of primary thymocyte differentiation prior to the CD4+CD8+ double-positive stage

Autor: Kristi A. Kerkel, Teresa S. Hawley, Robert G. Hawley, Lisa M. Spain, Bronwyn M. Owens

Publikováno v: British Journal of Haematology. 132:216-229

The TLX1/HOX11 homeobox gene is frequently activated in T-cell acute lymphoblastic leukaemia (T-ALL) by the t(10;14)(q24;q11) and t(7;10)(q35;q24) chromosomal translocations or by as yet unknown transcriptional mechanisms in the absence of 10q24 cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7f0286010442eec6ebce5b94b6a1ec
https://doi.org/10.1111/j.1365-2141.2005.05850.x

Reduction in CD4 central memory T-cell subset in costimulation modulator abatacept-treated patients with recent-onset type 1 diabetes is associated with slower C-peptide decline

Autor: Jun Deng, Tihamer Orban, Lisa M. Spain, Keith Moore, Mark Peakman, Qi Jiang, Peter A. Gottlieb, Sarah Muller, Ping Xu, Craig A. Beam

Publikováno v: Diabetes

We previously reported that continuous 24-month costimulation blockade by abatacept significantly slows the decline of β-cell function after diagnosis of type 1 diabetes. In a mechanistic extension of that study, we evaluated peripheral blood immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602a116ec566eac1da128de9970ce3a1
https://pubmed.ncbi.nlm.nih.gov/24834977

PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells

Autor: Edward W. Scott, Peter B. Langmuir, Lisa M. Spain, Anastasia Guerriero

Publikováno v: Blood. 95:879-885

The ets-family transcription factor PU.1 is required for the proper development of both myeloid and lymphoid progenitors. We used PU. 1-deficient animals to examine the role of PU.1 during dendritic cell development. PU.1(-/-)animals produce lymphoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3415623708231536090a50a0b1ca519d
https://doi.org/10.1182/blood.v95.3.879.003k13_879_885