Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lisa M. Prince"'
Autor:
Holly N. Cukier, Hyunjin Kim, Anthony J. Griswold, Simona G. Codreanu, Lisa M. Prince, Stacy D. Sherrod, John A. McLean, Derek M. Dykxhoorn, Kevin C. Ess, Peter Hedera, Aaron B. Bowman, M. Diana Neely
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-17 (2022)
Abstract We previously reported on two brothers who carry identical compound heterozygous PRKN mutations yet present with significantly different Parkinson’s Disease (PD) clinical phenotypes. Juvenile cases demonstrate that PD is not necessarily an
Externí odkaz:
https://doaj.org/article/9cfa439da89548cd82667ecafd084ddb
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
The risks of methylmercury (MeHg) toxicity are greatest during early life where it has long been appreciated that the developing nervous system is an especially sensitive target. Yet, understanding the discrete mechanisms of MeHg toxicity have been o
Externí odkaz:
https://doaj.org/article/cf6280ba577e457c91461eaaa3b011e2
Autor:
Lisa M. Prince, Matthew D. Rand
Publikováno v:
Frontiers in Genetics, Vol 8 (2018)
Methylmercury (MeHg) is a ubiquitous environmental contaminant and neurotoxicant that has long been known to cause a variety of motor deficits. These motor deficits have primarily been attributed to MeHg targeting of developing neurons and induction
Externí odkaz:
https://doaj.org/article/2dcd34cbc496445ba29e03372617a65a
Autor:
Holly N. Cukier, Hyunjin Kim, Anthony J. Griswold, Simona G. Codreanu, Lisa M. Prince, Stacy D. Sherrod, John A. McLean, Derek M. Dykxhoorn, Kevin C. Ess, Peter Hedera, Aaron B. Bowman, M. Diana Neely
Publikováno v:
NPJ Parkinson's disease. 8(1)
We previously reported on two brothers who carry identical compound heterozygous PRKN mutations yet present with significantly different Parkinson’s Disease (PD) clinical phenotypes. Juvenile cases demonstrate that PD is not necessarily an aging-as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f7749942dd91a9ded38ad4418767bf
https://pubmed.ncbi.nlm.nih.gov/35768426
https://pubmed.ncbi.nlm.nih.gov/35768426
Autor:
Linda H. Nie, Sana Tabbassum, Lisa M. Prince, Patricia Morcillo, Aaron B. Bowman, Michael Aschner, Pinjing Cheng, Chloe N. Rivers, Rekha C. Balachandran, Anna C Pfalzer, Ayodele J. Akinyemi, Frank M. Yanko
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 157
Hair is used as a biomarker of manganese (Mn) exposure, yet there is limited evidence to support its utility to quantify internal vs external Mn exposure. C57BL/6 J mice and Sprague-Dawley rats were exposed in two blocks of 3 subcutaneous injections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7926d43da4ae2782caa308aeea94f572
https://pubmed.ncbi.nlm.nih.gov/34534608
https://pubmed.ncbi.nlm.nih.gov/34534608
Publikováno v:
Neurotoxicol Teratol
Methylmercury (MeHg) is a persistent environmental neurotoxicant that may cause adverse neurodevelopmental effects. Previous studies showed that developmental MeHg exposure caused damage to brain functions that were unmasked after a silent period of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5272f152a8165e1bdf9f2c40def94d40
https://pubmed.ncbi.nlm.nih.gov/33626374
https://pubmed.ncbi.nlm.nih.gov/33626374
Autor:
Beatriz Ferrer, João Rocha, Abel Santamaría, Lisa M. Prince, Marcelo Farina, Aaron B. Bowman, Alexey A. Tinkov, Michael Aschner
Publikováno v:
Food Chem Toxicol
Several studies have demonstrated that heavy metals disrupt energy homeostasis. Leptin inhibits food intake and decreases body weight through activation of its receptor in the hypothalamus. The impact of heavy metals on leptin signaling in the hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48eb6f85200a2a298dfbf708cda40415
https://pubmed.ncbi.nlm.nih.gov/33338554
https://pubmed.ncbi.nlm.nih.gov/33338554
Autor:
Jyothi Thimmapuram, Shaojun Xie, Aaron B. Bowman, Hyunjin Kim, Anke M Tukker, M. Diana Neely, Lisa M. Prince, Michael Aschner
Publikováno v:
Food Chem Toxicol
The developing human brain is uniquely vulnerable to methylmercury (MeHg) resulting in lasting effects especially in developing cortical structures. Here we assess by single-cell RNA sequencing (scRNAseq) persistent effects of developmental MeHg expo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d100d676d3eb6a9a96d547cf3c971e5e
https://doi.org/10.1016/j.fct.2021.112288
https://doi.org/10.1016/j.fct.2021.112288
Autor:
Morgan G. Thomas, M. Diana Neely, Madeline R. Henley, Michael Aschner, Lisa M. Prince, Kiara K. Smith, Emily B. Warren, Aaron B. Bowman
Publikováno v:
Food Chem Toxicol
Developmental methylmercury (MeHg) exposure selectively targets the cerebral and cerebellar cortices, as seen by disruption of cytoarchitecture and glutamatergic (GLUergic) neuron hypoplasia. To begin to understand the mechanisms of this loss of GLUe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640c8dee082da700b251fca308f5d0f3
https://doi.org/10.1016/j.fct.2021.112178
https://doi.org/10.1016/j.fct.2021.112178
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Frontiers in Genetics
Frontiers in Genetics
The risks of methylmercury (MeHg) toxicity are greatest during early life where it has long been appreciated that the developing nervous system is an especially sensitive target. Yet, understanding the discrete mechanisms of MeHg toxicity have been o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428d5bb15ab2a4607f1f7e02822dc199
https://www.frontiersin.org/article/10.3389/fgene.2019.00666/full
https://www.frontiersin.org/article/10.3389/fgene.2019.00666/full