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Akademický článek

Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway.

Autor: Lyle J Burdine, Marie Schluterman Burdine, Linley Moreland, Brad Fogel, Lisa M Orr, Jennifer James, Richard H Turnage, Alan J Tackett

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0127943 (2015)

Constitutive activation of the Rearranged during Transfection (RET) proto-oncogene leads to the development of MEN2A medullary thyroid cancer (MTC). The relatively clear genotype/phenotype relationship seen with RET mutations and the development of M

Externí odkaz: https://doaj.org/article/538a51b5f03b489094d13e164552e24c

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Resistant starch slows the progression of CKD in the 5/6 nephrectomy mouse model

Autor: Samuel G. Mackintosh, Oleg Karaduta, Alan J. Tackett, Lisa M. Orr, Yasir Rahmatallah, Laxmi Yeruva, Boris Zybailov, Zeljko Dvanajscak, John M. Arthur, Galina V. Glazko

Publikováno v: Physiological Reports
Physiological Reports, Vol 8, Iss 19, Pp n/a-n/a (2020)

Background Resistant Starch (RS) improves CKD outcomes. In this report, we study how RS modulates host‐microbiome interactions in CKD by measuring changes in the abundance of proteins and bacteria in the gut. In addition, we demonstrate RS‐mediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa8045ea22f09e90ace8ded001d0dc2
https://doi.org/10.14814/phy2.14610

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ProteoViz: a tool for the analysis and interactive visualization of phosphoproteomics data

Autor: Zhengyu Wang, Kevin S. Naceanceno, Lisa M. Orr, Samantha Kendrick, Brendan Frett, Stephanie D. Byrum, Alan J. Tackett, Charity L. Washam, Aaron J. Storey, Hong-yu Li, Rick D. Edmondson, Samuel G. Mackintosh, Renny S. Lan

Publikováno v: Mol Omics

Quantitative proteomics generates large datasets with increasing depth and quantitative information. With the advance of mass spectrometry and increasingly larger data sets, streamlined methodologies and tools for analysis and visualization of phosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2525e234dfb5cc0ad4e8b32b8d5ee4
https://pubmed.ncbi.nlm.nih.gov/32347222

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Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome

Autor: Lisa M. Orr, Stephanie D. Byrum, Ricky D. Edmondson, Karen E. Beenken, Mark S. Smeltzer, Allister J. Loughran, Samuel G. Mackintosh, Alan J. Tackett, Aaron J. Storey

Publikováno v: Journal of Proteome Research

The staphylococcal accessory regulator A ( sarA) impacts the extracellular accumulation of Staphylococcus aureus virulence factors at the level of intracellular production and extracellular protease-mediated degradation. We previously used a proteomi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f7692ab90a82c1bf1ca722f56fcece
http://europepmc.org/articles/PMC6209314

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Metaproteomics Reveals Potential Mechanisms by which Dietary Resistant Starch Supplementation Attenuates Chronic Kidney Disease Progression in Rats

Autor: Yasir Rahmatallah, Alan J. Tackett, Oleg Karaduta, Stephanie D. Byrum, Dorothy A. Kieffer, Dmitri S. Andreyev, Taylor McElroy, Roy J. Martin, Sean H. Adams, Nosratola D. Vaziri, Lisa M. Orr, Boris Zybailov, John M. Arthur, Galina V. Glazko, Ricky D. Edmondson, Samuel G. Mackintosh

Publikováno v: PLoS ONE
Zybailov, Boris L; Glazko, Galina V; Rahmatallah, Yasir; Andreyev, Dmitri S; McElroy, Taylor; Karaduta, Oleg; et al.(2019). Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats.. PloS one, 14(1), e0199274. doi: 10.1371/journal.pone.0199274. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5zp1p5gf
PLoS ONE, Vol 14, Iss 1, p e0199274 (2019)
PloS one, vol 14, iss 1

BackgroundResistant starch is a prebiotic metabolized by the gut bacteria. It has been shown to attenuate chronic kidney disease (CKD) progression in rats. Previous studies employed taxonomic analysis using 16S rRNA sequencing and untargeted metabolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457647ed60a9fe0cca07f11a17ef8639

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Time- and radiation-dose dependent changes in the plasma proteome after total body irradiation of non-human primates: Implications for biomarker selection

Autor: Lisa M. Orr, Alan J. Tackett, Marie Schluterman Burdine, Mylene Pouliot, Samuel G. Mackintosh, Stephanie D. Byrum, Simon Authier, Martin Hauer-Jensen

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0174771 (2017)
PLoS ONE

Acute radiation syndrome (ARS) is a complex multi-organ disease resulting from total body exposure to high doses of radiation. Individuals can be exposed to total body irradiation (TBI) in a number of ways, including terrorist radiological weapons or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39919d92b8b7eebfafcf5e6fd9fb35f
http://europepmc.org/articles/PMC5370149?pdf=render

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1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice

Autor: Gunnar Boysen, Jessica H. Hartman, Lisa M. Orr, Grover P. Miller, Lee Ann MacMillan-Crow, Alan J. Tackett, Samuel G. Mackintosh, Stephanie D. Byrum, Andres A. Caro, Lance M. Hallberg, Bill T. Ameredes

Publikováno v: Toxicology. 378

Cytochrome P450 2E1 (CYP2E1) metabolizes low molecular weight hydrophobic compounds, including 1,3-butadiene, which is converted by CYP2E1 to electrophilic epoxide metabolites that covalently modify cellular proteins and DNA. Previous CYP2E1 studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20762f68e6e8f0cd1f959e04871effc3
https://pubmed.ncbi.nlm.nih.gov/28082109

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Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma

Autor: Sara C. Shalin, Fade Mahmoud, Alan J. Tackett, Matthew R. Reynolds, Bradley D. Shields, Stephanie D. Byrum, Lisa M. Orr, Lauren E. Davis, Nathan L. Avaritt, Deepanwita Sengupta, Samuel G. Mackintosh

Publikováno v: Molecularcellular proteomics : MCP. 15(3)

Normal cell growth is characterized by a regulated epigenetic program that drives cellular activities such as gene transcription, DNA replication, and DNA damage repair. Perturbation of this epigenetic program can lead to events such as mis-regulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9cc7bdb61886bf404e83687dc09b27
https://pubmed.ncbi.nlm.nih.gov/26621846

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Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway

Autor: Linley E. Moreland, Brad Fogel, Jennifer E. James, Marie Schluterman Burdine, Richard H. Turnage, Lisa M. Orr, Lyle Burdine, Alan J. Tackett

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0127943 (2015)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746858865fcd60d1f1f90c68b09ca6cd
http://europepmc.org/articles/PMC4466258?pdf=render

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