Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lisa M. Newman"'
Autor:
Barbara B Bendlin, Lisa M Newman, Michele L Ries, Luigi Puglielli, Cynthia M Carlsson, Mark A Sager, Howard A Rowley, Catherine L Gallagher, Auriel A Willette, Andrew L Alexander, Sanjay Asthana, Sterling C Johnson
Publikováno v:
Frontiers in Aging Neuroscience, Vol 2 (2010)
The use of non-steroidal anti-inflammatory drugs (NSAIDs) in humans is associated with brain differences including decreased number of activated microglia. In animals, NSAIDs are associated with reduced microglia, decreased amyloid burden, and neuron
Externí odkaz:
https://doaj.org/article/201a248444384f2891fed0159cbddc65
Autor:
John H. Grate, Gray David R, Christopher S Davis, Roger A. Sheldon, John M. Gruber, Alica Wang, Steven K. Ma, Gjalt W. Huisman, Lisa M. Newman
Publikováno v:
Green Chem.. 12:81-86
The development of a green-by-design, two-step, three-enzyme process for the synthesis of a key intermediate in the manufacture of atorvastatin, the active ingredient of the cholesterol lowering drug Lipitor®, is described. The first step involves t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d75a7be10925b2914481e0917afc17e
https://doi.org/10.1039/b919115c
https://doi.org/10.1039/b919115c
Publikováno v:
Brain Imaging and Behavior. 1:3-10
Voxel-based morphometry (VBM) was used to examine the relationship between gray matter (GM) volume and performance on two commonly used clinical neuropsychological measures of frontal lobe or executive function, the Trail Making Test part B (TrailsB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e52fb310ddc54e00088bdf996a9dbec
https://doi.org/10.1007/s11682-007-9000-5
https://doi.org/10.1007/s11682-007-9000-5
Autor:
Roger A. Sheldon, Lisa M. Newman, Emily Mundorff, Richard J. Fox, John C Whitman, Gjalt W. Huisman, Loleta M Chung, Steven K. Ma, S. Christopher Davis, Charlene Ching, John M. Gruber, Vesna Gavrilovic, John H. Grate, Sheela Muley, Sarena Tam
Publikováno v:
Nature Biotechnology. 25:338-344
We describe a directed evolution approach that should find broad application in generating enzymes that meet predefined process-design criteria. It augments recombination-based directed evolution by incorporating a strategy for statistical analysis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4402e955f779b04c3061c8cc90a7d03
https://doi.org/10.1038/nbt1286
https://doi.org/10.1038/nbt1286
Publikováno v:
Tetrahedron. 60:729-734
Herein we report a new preparation of 4-hydroxy-2,5-dimethyl-2,3-dihydrofuran-3-one, the flavor compound strawberry furanone, based on a ‘green’ approach with a minimum number of steps. The first step is an enzymatic dioxygenation of p -xylene to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74dfb8285d02ab4957268f7826efb4eb
https://doi.org/10.1016/j.tet.2003.10.105
https://doi.org/10.1016/j.tet.2003.10.105
Autor:
Aleksey Zaks, Guy Gloor, James Lalonde, Ben Mijts, George T. F. Wong, Matt Tobin, Gjalt W. Huisman, Sheela Muley, Xiyun Zhang, Alexandre Ambrogelly, Azzeddine Lekhal, Tao Li, Tim Brennan, Jack Liang, Lisa M. Newman
Publikováno v:
Journal of the American Chemical Society. 134(14)
The key structural feature in Boceprevir, Merck’s new drug treatment for hepatitis C, is the bicyclic [3.1.0]proline moiety “P2”. During the discovery and development stages, the P2 fragment was produced by a classical resolution approach. As t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639368693bf55a033f423505010bd9bf
https://pubmed.ncbi.nlm.nih.gov/22409428
https://pubmed.ncbi.nlm.nih.gov/22409428
Publikováno v:
Biodegradation. 4:39-50
Cytochrome P-450CAM was shown to be the primary catalyst mediating reductive dehalogenation of polychlorinated ethanes by Pseudomonas putida G786. Under anaerobic conditions, the enzyme catalyzed reductive elimination reactions in vivo with the subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f1b4dd6d411650d8f66b48229dba31
https://doi.org/10.1007/bf00701453
https://doi.org/10.1007/bf00701453
Publikováno v:
Journal of Leukocyte Biology. 52:645-651
Leukotriene B4, an autacoid metabolite of arachidonic acid produced by polymorphonuclear neutrophils, induces chemokinesis, chemotaxis, and adhesion of these cells at sites of inflammation. Because neutrophil infiltration is a self-limited process, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c743e54d7f06b5bb2c07f54db1df51da
https://doi.org/10.1002/jlb.52.6.645
https://doi.org/10.1002/jlb.52.6.645
Autor:
Donald G. McLaren, Sterling C. Johnson, Michele E. Fitzgerald, Guofan Xu, Barbara B. Bendlin, Michele L. Ries, Erik K. Kastman, Lisa M. Newman, Kristopher J. Kosmatka, Britta M. Jabbar
Publikováno v:
Alzheimer's & Dementia. 4
Background: Memory formation and retrieval is a dynamic process that employs a network of brain regions. Here we aim to investigate the neural correlates of memory formation in healthy middle-aged individuals using an event-related fMRI paradigm. Met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2889a2b4eb4894bc5f30cafd9ee09aa5
https://doi.org/10.1016/j.jalz.2008.05.852
https://doi.org/10.1016/j.jalz.2008.05.852
Autor:
Sterling C. Johnson, Guofan Xu, Donald G. McLaren, Britta M. Jabbar, Michele E. Fitzgerald, Barbara B. Bendlin, Lisa M. Newman, Michele L. Ries, Erik K. Kastman, Kristopher J. Kosmatka
Publikováno v:
Alzheimer's & Dementia. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7798e63edde953b9aa033d376a363412
https://doi.org/10.1016/j.jalz.2008.05.142
https://doi.org/10.1016/j.jalz.2008.05.142