Anthropoid primate-specific retroviral element THE1B controls expression of CRH in placenta and alters gestation length.

Autor: Caitlin E Dunn-Fletcher, Lisa M Muglia, Mihaela Pavlicev, Gernot Wolf, Ming-An Sun, Yueh-Chiang Hu, Elizabeth Huffman, Shivani Tumukuntala, Katri Thiele, Amrita Mukherjee, Sandra Zoubovsky, Xuzhe Zhang, Kayleigh A Swaggart, Katherine Y Bezold Lamm, Helen Jones, Todd S Macfarlan, Louis J Muglia

Publikováno v: PLoS Biology, Vol 16, Iss 9, p e2006337 (2018)

Pregnancy and parturition are intricately regulated to ensure successful reproductive outcomes. However, the factors that control gestational length in humans and other anthropoid primates remain poorly defined. Here, we show the endogenous retrovira

Externí odkaz: https://doaj.org/article/5187b61a9cc04b9bb9eb293210d8a053

Genetic Associations With Gestational Duration and Spontaneous Preterm Birth

Autor: David A. Hinds, Bjarke Feenstra, Bo Jacobsson, Nadia K. Litterman, Mika Rämet, Kelli K Ryckman, Lisa M. Muglia, Youna Hu, Jamie Maziarz, Minna K. Karjalainen, Leah C. Kottyan, Carmy Forney, Mauris C. Nnamani, Daniel Miller, Johanna M. Huusko, Matthew T. Weirauch, Ellen A. Nohr, Allison Momany, George Davey Smith, Frank Geller, Xueping Liu, Bruce Bedell, Aarno Palotie, Mihaela Pavlicev, Arun R. Chavan, Louis J. Muglia, Pan Pan Jiang, Kari Teramo, Heather A. Boyd, Mads Melbye, Mikko Hallman, Verena Sengpiel, Günter P. Wagner, Julius Juodakis, Xiaoting Chen, Jonas Bacelis, Ge Zhang, Laura Russell

Publikováno v: Zhang, G, Feenstra, B, Bacelis, J, Liu, X, Muglia, L M, Juodakis, J, Miller, D E, Litterman, N, Jiang, P-P, Russell, L, Hinds, D A, Hu, Y, Weirauch, M T, Chen, X, Chavan, A R, Wagner, G P, Pavličev, M, Nnamani, M C, Maziarz, J, Karjalainen, M K, Rämet, M, Sengpiel, V, Geller, F, Boyd, H A, Palotie, A, Momany, A, Bedell, B, Ryckman, K K, Huusko, J M, Forney, C R, Kottyan, L C, Hallman, M, Teramo, K, Nohr, E A, Davey Smith, G, Melbye, M, Jacobsson, B & Muglia, L J 2017, ' Genetic Associations with Gestational Duration and Spontaneous Preterm Birth ', The New England Journal of Medicine, vol. 377, no. 12, pp. 1156-1167 . https://doi.org/10.1056/NEJMoa1612665
Zhang, G, Feenstra, B, Bacelis, J, Liu, X, Muglia, L M, Juodakis, J, Litterman, N, Hinds, D A, Hu, Y, Weirauch, M T, Chen, X, Chavan, A R, Wagner, G P, Pavličev, M, Nnamani, M C, Maziarz, J, Karjalainen, M K, Rämet, M, Sengpiel, V, Geller, F, Boyd, H A, Palotie, A, Momany, A, Bedell, B, Ryckman, K K, Huusko, J M, Forney, C R, Kottyan, L C, Hallman, M, Teramo, K, Nohr, E A, Smith, G D, Melbye, M, Jacobsson, B & Muglia, L J 2017, ' Genetic associations with gestational duration and spontaneous preterm birth ', New England Journal of Medicine, vol. 377, no. 12, pp. 1156-1167 . https://doi.org/10.1056/NEJMoa1612665
The New England Journal of Medicine
Zhang, G, Feenstra, B, Bacelis, J, Liu, X, Muglia, L M, Juodakis, J, Miller, D E, Litterman, N, Jiang, P P, Russell, L, Hinds, D A, Hu, Y, Weirauch, M T, Chen, X, Chavan, A R, Wagner, G P, Pavličev, M, Nnamani, M C, Maziarz, J, Karjalainen, M K, Ramet, M, Sengpiel, V, Geller, F, Boyd, H A, Palotie, A, Momany, A, Bedell, B, Ryckman, K K, Huusko, J M, Forney, C R, Kottyan, L C, Hallman, M, Teramo, K, Nohr, E A, Davey Smith, G, Melbye, M, Jacobsson, B & Muglia, L J 2018, ' Genetic Associations with Gestational Duration and Spontaneous Preterm Birth ', Obstetrical and Gynecological Survey, vol. 73, no. 2, pp. 83-85 . https://doi.org/10.1097/01.ogx.0000530434.15441.45

Background: Despite evidence that genetic factors contribute to the duration of gestation and the risk of preterm birth, robust associations with genetic variants have not been identified. We used large data sets that included the gestational duratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c91222807de9a168bf9bb010ac555b
https://doi.org/10.1097/01.ogx.0000530434.15441.45

Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic–pituitary–adrenal axis by gene targeting in mice

Autor: Lisa M. Muglia, Louis J. Muglia, Gloria Laryea, Melinda G. Arnett

Publikováno v: Frontiers in Neuroendocrinology. 36:150-164

Negative feedback regulation of glucocorticoid (GC) synthesis and secretion occurs through the function of glucocorticoid receptor (GR) at sites in the hypothalamic-pituitary-adrenal (HPA) axis, as well as in brain regions such as the hippocampus, pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e5326cd735a32a014c37c1695c4823
https://doi.org/10.1016/j.yfrne.2014.09.002

Genetic Approaches to Hypothalamic-Pituitary-Adrenal Axis Regulation

Autor: Lisa M. Muglia, Louis J. Muglia, Gloria Laryea, Melinda G. Arnett

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 41(1)

The normal function of the hypothalamic-pituitary-adrenal (HPA) axis, and resultant glucocorticoid (GC) secretion, is essential for human health. Disruption of GC regulation is associated with pathologic, psychological, and physiological disease stat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974de3b7efd30febb092f930b405a7af
https://pubmed.ncbi.nlm.nih.gov/26189452

Calcium-Stimulated Adenylyl Cyclases Modulate Ethanol-Induced Neurodegeneration in the Neonatal Brain

Autor: Amanda A. Shute, Lisa M. Muglia, Sherri K. Vogt, Tim West, John W. Olney, Ricardo A. Indacochea, David M. Holtzman, Steven Mennerick, Ann Benz, Timothy T. Tran, Louis J. Muglia, James W. Maas

Publikováno v: The Journal of Neuroscience. 25:2376-2385

Fetal alcohol exposure results in cognitive and neurobehavioral deficits, but the effects of modifying genetic loci on the severity of these sequelas have not been well characterized. Although the cAMP signaling pathway has been shown to be an import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69a53127280fb260e4a2d4cc7ab3a2d
https://doi.org/10.1523/jneurosci.4940-04.2005