Výsledky vyhledávání - "Lisa M. McGregor"

A phase 1 trial of everolimus and bevacizumab in children with recurrent solid tumors

Autor: Olivia Campagne, Natasha Sahr, Lisa M. McGregor, April Sykes, Wayne L. Furman, Ruth G. Tatevossian, Clinton F. Stewart, Sujuan Jia, Victor M. Santana

Publikováno v: Cancer

Background The prognosis for children with recurrent solid tumors generally is poor. Targeting mammalian target of rapamycin (mTOR) and vascular endothelial growth factor A with everolimus and bevacizumab, respectively, synergistically improves progr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584268900d3899b04869c0d0b31d53e5
https://doi.org/10.1002/cncr.32722

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Attendance at National Cancer Institute and Children's Oncology Group Facilities for Children, Adolescents, and Young Adults with Cancer in Pennsylvania: A Population-Based Study

Autor: Lisa M. McGregor, Joel E. Segel, Pooja Rao, Barbara A. Miller, Eugene J. Lengerich, Joseph J. Drabick

Publikováno v: J Adolesc Young Adult Oncol

Purpose: Adolescents and young adults (AYAs) with cancer are a vulnerable population with decreased attendance at National Cancer Institute (NCI) comprehensive cancer centers and Children's Oncology Group (COG) facilities. Decreased attendance at NCI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd6156ac2e614386886e784e0c861a8
https://pubmed.ncbi.nlm.nih.gov/31600095

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Repeat nephron-sparing surgery for children with bilateral Wilms tumor

Autor: Matthew J. Krasin, Mark A. Williams, Jeffrey S. Dome, Lisa M. McGregor, Kathleen Kieran, Andrew M. Davidoff

Publikováno v: Journal of Pediatric Surgery. 49:149-153

Background Renal insufficiency is a significant complication of Wilms tumor treatment in the 5% with bilateral disease. Nephron-sparing surgery (NSS) is recommended after neoadjuvant chemotherapy initially. However, the role of NSS in recurrent disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0432fef097abf66ddf872ee46ce732c2
https://doi.org/10.1016/j.jpedsurg.2013.09.048

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Establishment and Characterization of the First Pediatric Adrenocortical Carcinoma Xenograft Model Identifies Topotecan as a Potential Chemotherapeutic Agent

Autor: Kimberly S Mercer, Catherine A. Billups, Larisa V. Debelenko, Carlos Rodriguez-Galindo, Christopher L. Morton, Andrew M. Davidoff, Raul C. Ribeiro, Emilia M. Pinto, Lisa M. McGregor, Gerard P. Zambetti

Publikováno v: Clinical Cancer Research. 19:1740-1747

Purpose: Pediatric adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy. Conventional chemotherapeutic agents have shown limited utility and are largely ineffective in treating children with advanced ACC. The lack of cell lines a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eaa06fa0b082024d782d18d436d23fe
https://doi.org/10.1158/1078-0432.ccr-12-3354

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Phase I and Clinical Pharmacology Study of Bevacizumab, Sorafenib, and Low-Dose Cyclophosphamide in Children and Young Adults with Refractory/Recurrent Solid Tumors

Autor: Shuiying Hu, M. Beth McCarville, Lisa M. McGregor, Fariba Navid, Jianrong Wu, John C. Panetta, Wilburn E. Reddick, Demba Fofana, Wing Leung, Sharyn D. Baker, Wayne L. Furman, Victor M. Santana, David C. Turner, Sheri L. Spunt, Clinton F. Stewart, Andrew M. Davidoff, Catherine A. Billups

Publikováno v: Clinical Cancer Research. 19:236-246

Purpose: To determine the maximum-tolerated dose (MTD), dose-limiting toxicities (DLT), pharmacokinetics, and pharmacodynamics of sorafenib, bevacizumab, and low-dose oral cyclophosphamide in children and young adults with recurrent/refractory solid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb868450cbfee32c8ee40328261abf0b
https://doi.org/10.1158/1078-0432.ccr-12-1897

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The promotion of HL-1 cardiomyocyte beating using anisotropic collagen-GAG scaffolds

Autor: Emily A. Gonnerman, Douglas O. Kelkhoff, Brendan A.C. Harley, Lisa M. McGregor

Publikováno v: Biomaterials. 33:8812-8821

Biomaterials for myocardial tissue engineering must balance structural, mechanical and bioactivity concerns. This work describes the interaction between HL-1 cardiomyocytes and a series of geometrically anisotropic collagen-GAG (CG) scaffolds with al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8cc1edde66cb561b2b776ff70851b2
https://doi.org/10.1016/j.biomaterials.2012.08.051

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Intensity modulated radiation therapy provides excellent local control in high-risk abdominal neuroblastoma

Autor: Catherine A. Billups, Lisa M. McGregor, Wayne L. Furman, Atmaram S. Pai Panandiker, Andrew M. Davidoff, Chris Beltran

Publikováno v: Pediatric Blood & Cancer. 60:761-765

Background Locoregional failure is a significant concern in patients with high-risk abdominal neuroblastoma (NB) receiving radiotherapy. Locoregional control outcomes were studied in children with NB receiving intensity modulated radiotherapy (IMRT).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f97c68ba2cd595af25682d6f4f24f2d
https://doi.org/10.1002/pbc.24350

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A single-arm pilot phase II study of gefitinib and irinotecan in children with newly diagnosed high-risk neuroblastoma

Autor: Wayne L. Furman, Peter J. Houghton, Dana Hawkins, Victor M. Santana, Jianrong Wu, M. Beth McCarville, Valerie McPherson, Mihaela Onciu, Lisa M. McGregor, Sandy Kovach, Clinton F. Stewart, Andrew M. Davidoff, Catherine A. Billups

Publikováno v: Investigational New Drugs. 30:1660-1670

Background Gefitinib potently inhibits neuroblastoma proliferation in vitro, and the gefitinib/irinotecan combination shows greater than additive activity against neuroblastoma xenografts. This Phase II pilot study estimated the rate of response to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104ccf5c584315cef4ba5acc9423a91a
https://doi.org/10.1007/s10637-011-9724-3

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Dose escalation of intravenous irinotecan using oral cefpodoxime: A phase I study in pediatric patients with refractory solid tumors

Autor: Wayne L. Furman, Fariba Navid, Victor M. Santana, Jianrong Wu, Amy Wozniak, Peter J. Houghton, Michael Tagen, M. Beth McCarville, Lisa M. McGregor, Carlos Rodriguez-Galindo, Clinton F. Stewart, Kristine R. Crews

Publikováno v: Pediatric Blood & Cancer. 58:372-379

Background—Administration of an oral cephalosporin allowed advancement of the dosage of oral irinotecan. This study investigates whether administration of an oral cephalosporin increases the maximum tolerated dose (MTD) of intravenous irinotecan. P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9d42d7fee98fea50478647828f7c054
https://doi.org/10.1002/pbc.23075

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