Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lisa M. McGinley"'
Autor:
Kevin S. Chen, Mohamed H. Noureldein, Lisa M. McGinley, John M. Hayes, Diana M. Rigan, Jacquelin F. Kwentus, Shayna N. Mason, Faye E. Mendelson, Masha G. Savelieff, Eva L. Feldman
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionStem cells are a promising therapeutic in Alzheimer’s disease (AD) given the complex pathophysiologic pathways involved. However, the therapeutic mechanisms of stem cells remain unclear. Here, we used spatial transcriptomics to elucidat
Externí odkaz:
https://doaj.org/article/34fd950a9d53474a8e6ce622502373c2
Autor:
Lisa M. McGinley, Kevin S. Chen, Shayna N. Mason, Diana M. Rigan, Jacquelin F. Kwentus, John M. Hayes, Emily D. Glass, Evan L. Reynolds, Geoffrey G. Murphy, Eva L. Feldman
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 9, Pp n/a-n/a (2022)
Abstract Background As the field of stem cell therapy advances, it is important to develop reliable methods to overcome host immune responses in animal models. This ensures survival of transplanted human stem cell grafts and enables predictive effica
Externí odkaz:
https://doaj.org/article/34e1b36c1cdc4cd3b943037b7a4f9d9d
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
Alzheimer's disease (AD) is a growing problem worldwide, and there are currently no effective treatments for this devastating disease. The neurotrophic growth factors insulin and insulin-like growth factor-I (IGF-I) are currently being investigated a
Externí odkaz:
https://doaj.org/article/5e2237933edd4b5ab022adc1e5680ab5
Autor:
Eva L. Feldman, Maegan A. Tabbey, Kevin S. Chen, Stacey A. Sakowski, John M. Hayes, Lisa M. McGinley, Elizabeth S. Bruno, Josh S. Chang, Osama N. Kashlan, Faye E. Mendelson, Karl Johe
Publikováno v:
Nature Protocols. 14:331-349
Despite decades of research, pharmacological therapies for spinal cord motor pathologies are limited. Alternatives using macromolecular, viral, or cell-based therapies show early promise. However, introducing these substances into the spinal cord, pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d469239034e0f380dfe234778e78f775
https://doi.org/10.1038/s41596-018-0095-5
https://doi.org/10.1038/s41596-018-0095-5
Autor:
Ingrid L. Bergin, John M. Hayes, Lisa M. McGinley, Jacquelin F. Kwentus, Kevin S. Chen, Jennifer Kollmer, Aaron W. Stebbins, Stacey A. Sakowski, Cynthia A. Chestek, Osama N. Kashlan, Matthew S. Willsey, Eva L. Feldman, Shayna N. Mason, Parag G. Patil, Crystal Pacut, Caleb B. Bell, Geoffrey G. Murphy
Publikováno v:
Stem Cells Translational Medicine
Stem cell transplantation therapies are currently under investigation for central nervous system disorders. Although preclinical models show benefit, clinical translation is somewhat limited by the absence of reliable noninvasive methods to confirm t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b623b67d99b79a405913c1fdfe0a79d8
https://pubmed.ncbi.nlm.nih.gov/32841522
https://pubmed.ncbi.nlm.nih.gov/32841522
Autor:
Crystal Pacut, Kevin S. Chen, Tom Hazel, Eva L. Feldman, Lisa M. McGinley, Osama N. Kashlan, J. Simon Lunn, Erika Sims, Karl Johe, Stacey A. Sakowski, Elizabeth S. Bruno
Publikováno v:
Stem Cells Translational Medicine
A human cortex-derived neural stem cell (NSC) line modified to express insulin-like growth factor-I (IGF-I), HK532-IGF-I, is characterized in this report. The cell line is under study as a cellular therapy for Alzheimer’s disease (AD). HK532-IGF-I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc64491df11afcda2ba6c95dd5a8442
https://doi.org/10.5966/sctm.2015-0103
https://doi.org/10.5966/sctm.2015-0103
Autor:
John M. Hayes, Lisa M. McGinley, Osama N. Kashlan, Geoffrey G. Murphy, Samy R. Kashlan, Eva L. Feldman, Kevin S. Chen, Julia Raykin, Elizabeth S. Bruno, Karl Johe
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Stem cell transplantation offers a potentially transformative approach to treating neurodegenerative disorders. The safety of cellular therapies is established in multiple clinical trials, including our own in amyotrophic lateral sclerosis. To initia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0b9269c30d24408c573283b72255d2
https://doi.org/10.1038/s41598-018-33017-6
https://doi.org/10.1038/s41598-018-33017-6
Autor:
Audrey B. Erman, Osama N. Kashlan, Kevin S. Chen, Stacey A. Sakowski, Robbi A. Kupfer, Lisa M. McGinley, Sang Su Oh, Eva L. Feldman, Bader N. Kashlan
Publikováno v:
Neurodegenerative Diseases. 15:121-126
Background: Almost all patients with amyotrophic lateral sclerosis (ALS) develop bulbar symptoms; therefore, it is important to have valid animal models that accurately reflect these features. While the SOD1-G93A rat is extensively used as an ALS mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b096c8a0c1acb48632de55eaefa76ef2
https://doi.org/10.1159/000377725
https://doi.org/10.1159/000377725
Autor:
Alessia Stocca, Daniel O'Toole, Lisa M. McGinley, Timothy O'Brien, Jill McMahon, Aidan Flynn, Aoife Duffy
Mesenchymal stem cell (MSC) therapy offers the potential to promote recovery after myocardial infarction (MI). However, therapeutic efficacy may be limited by poor survival and retention of transplanted cells. A combination of gene and cell therapy h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf1332e97c2e5850566c55ae0f8b32c
http://hdl.handle.net/10379/12783
http://hdl.handle.net/10379/12783
Autor:
Angela Duffy, Timothy O'Brien, Daniel O'Toole, Cynthia M. Coleman, Sean O. Hynes, Kaveh Mashayekhi, Lisa M. McGinley, Enda O'Connell, Alessia Stocca, S. Tunev, Sherif Sultan, Niamh Hynes
Publikováno v:
Atherosclerosis. 221(2)
Objective The most common cause of death in diabetes mellitus is cardiovascular disease. Patients frequently undergo vascular intervention such as stenting. The occurrence of in stent restenosis (ISR) has been reduced by the use of drug eluting stent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99dcb5cbba1ce38616404757fb5a91ee
https://pubmed.ncbi.nlm.nih.gov/22381691
https://pubmed.ncbi.nlm.nih.gov/22381691