Výsledky vyhledávání - "Lisa M. Graham"

Akademický článek

The Relationship between the Oral Microbiota and Metabolic Syndrome

Autor: Yvonne Prince, Glenda M. Davison, Saarah F. G. Davids, Rajiv T. Erasmus, Andre P. Kengne, Lisa M. Graham, Shanel Raghubeer, Tandi E. Matsha

Publikováno v: Biomedicines, Vol 11, Iss 1, p 3 (2022)

The oral microbiota plays a crucial role in both systemic inflammation and metabolic syndrome (MetS), which is characterised by low-grade inflammation. Studies have analysed the gut microbiota using stool specimens from subjects with MetS; however, t

Externí odkaz: https://doaj.org/article/815c53bf8b494b8ab8c9fd30a2b4b1aa

Zobrazit plný text záznamu

Akademický článek

The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells

Autor: Catherine H. Kaschula, Rosanna Tuveri, Ellen Ngarande, Kevin Dzobo, Christopher Barnett, Daniel A. Kusza, Lisa M. Graham, Arieh A. Katz, Mohamed Suhail Rafudeen, M. Iqbal Parker, Roger Hunter, Georgia Schäfer

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-16 (2019)

Abstract Background Garlic has been used for centuries for its flavour and health promoting properties that include protection against cancer. The vinyl disulfide-sulfoxide ajoene is one of the phytochemicals found in crushed cloves, hypothesised to

Externí odkaz: https://doaj.org/article/baae6046d21044569989b9b60751f18f

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

The Role of Syk/CARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis Infections

Autor: Mohlopheni Jackson Marakalala, Lisa M. Graham, Gordon D. Brown

Publikováno v: Clinical and Developmental Immunology, Vol 2010 (2010)

There is increasing interest in understanding the mechanisms underlying the interactions that occur between Mycobacterium tuberculosis and host innate immune cells. These cells express pattern recognition receptors (PRRs) which recognise mycobacteria

Externí odkaz: https://doaj.org/article/a6bd297aed8941e3b6e2e827c8137434

Zobrazit plný text záznamu

The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells

Autor: Mohamed Suhail Rafudeen, Christopher B. Barnett, Ellen Ngarande, Kevin Dzobo, Lisa M. Graham, Georgia Schäfer, Catherine H. Kaschula, Rosanna Tuveri, M. Iqbal Parker, Arieh A. Katz, Daniel A. Kusza, Roger Hunter

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-16 (2019)
BMC Cancer

Background Garlic has been used for centuries for its flavour and health promoting properties that include protection against cancer. The vinyl disulfide-sulfoxide ajoene is one of the phytochemicals found in crushed cloves, hypothesised to act by S-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d6c1c74c954cd0a9a00b1ef4f0aa5d
http://link.springer.com/article/10.1186/s12885-019-5388-8

Zobrazit plný text záznamu

Plný text ve formátu HTML

The Garlic CompoundZ‐Ajoene,S‐Thiolates COX2 and STAT3 and Dampens the Inflammatory Response in RAW264.7 Macrophages

Autor: Georgia Schäfer, Christopher B. Barnett, Catherine H. Kaschula, Roger Hunter, Jessica K. Hitchcock, Lisa M. Graham, Nonkululeko Mkwanazi, Arieh A. Katz

Publikováno v: Molecular Nutrition & Food Research. 65:2000854

Scope Garlic (Allium sativum) has been used for centuries as both a prophylactic and therapeutic medicinal agent to control inflammation-associated pathologies. To investigate the underlying mechanisms, we established an in vitro inflammatory model u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7d4fd866ae22d4be37f159e1bc1bcf
https://doi.org/10.1002/mnfr.202000854

Zobrazit plný text záznamu

Flow Cytometry To Assess Cerebrospinal Fluid Fungal Burden in Cryptococcal Meningitis

Autor: Robert J. Wilkinson, David G. Lalloo, Thomas J. Scriba, Graeme Meintjes, James Scriven, Britta C. Urban, Lisa M. Graham, David R. Boulware, Charlotte Schutz

Publikováno v: Journal of Clinical Microbiology

Fungal burden in the cerebrospinal fluid is an important determinant of mortality in cryptococcal meningitis, but its use in aiding clinical decision making is hampered by the time involved to perform quantitative cultures. Here, we demonstrate the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b7b49d4b6870fb839e74416c5bbe3c
https://doi.org/10.1128/jcm.03002-15

Zobrazit plný text záznamu

Vimentin Modulates Infectious Internalization of Human Papillomavirus 16 Pseudovirions

Autor: Georgia Schäfer, Lisa M. Graham, Dirk M. Lang, Martina Bergant Marušič, Arieh A. Katz, Melissa J. Blumenthal

Publikováno v: Journal of Virology

Human papillomavirus (HPV) infection is the most common viral infection of the reproductive tract, with virtually all cases of cervical cancer being attributable to infection by oncogenic HPVs. However, the exact mechanism and receptors used by HPV t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1631451a5947adeedbb8f98d9fafaca
https://pubmed.ncbi.nlm.nih.gov/28566373

Zobrazit plný text záznamu

The CSF immune response in HIV-1-associated cryptococcal meningitis: macrophage activation, correlates of disease severity, and effect of antiretroviral therapy

Autor: Robert J. Wilkinson, Thomas J. Scriba, David G. Lalloo, Graeme Meintjes, Britta C. Urban, Katalin A. Wilkinson, David R. Boulware, James Scriven, Lisa M. Graham, Charlotte Schutz

Publikováno v: Journal of Acquired Immune Deficiency Syndromes (1999)

Supplemental Digital Content is Available in the Text.
Background: Immune modulation may improve outcome in HIV-associated cryptococcal meningitis. Animal studies suggest alternatively activated macrophages are detrimental but human studies are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a0948aeb03b61e8674a72f60125676
http://hdl.handle.net/10044/1/51338

Zobrazit plný text záznamu

New CD1d agonists: Synthesis and biological activity of 6″-triazole-substituted α-galactosyl ceramides

Autor: Steven A. Porcelli, Liam R. Cox, Lisa M. Graham, Erin L. Foster, Gurdyal S. Besra, Peter J. Jervis

Publikováno v: Bioorganic & Medicinal Chemistry Letters

Graphical abstract 6″-Triazole-substituted-α-galactosyl ceramides 12a–f, 13, 14 and 15 have been synthesised. Along with azide precursor 11, their ability to activate iNKT cells and stimulate the production of IL-2 cytokines in vitro, and IFN-γ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a887dbba036b4019232189f5f7e8ff
https://doi.org/10.1016/j.bmcl.2012.05.009

Zobrazit plný text záznamu

The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase*

Autor: Ten Feizi, Janet A. Willment, Matti Kimberg, Gordon D. Brown, María Asunción Campanero-Rhodes, Peter Sobieszczuk, Angelina S. Palma, Vandana Gupta, William G. Hornsell, Stella K. Kim, Kevin M. Dennehy, Lisa M. Graham, Reto Guler, Georgia Schäfer, Delyth M. Reid

Publikováno v: The Journal of Biological Chemistry
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname

11 pags, 7 figs
CLECSF8 is a poorly characterized member of the "Dectin-2 cluster" of C-type lectin receptors and was originally thought to be expressed exclusively by macrophages. We show here that CLECSF8 is primarily expressed by peripheral b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26ce17f5889dfdcc1444c68d77fd667
http://europepmc.org/articles/PMC3406680

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání