Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lisa M. Garofalo"'
Publikováno v:
Organic Process Research & Development. 16:1870-1873
A concise synthesis of a tetrahydropyrazolopyrazine building block is described. 5-Methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-ylamine was prepared in three steps and 80% yield from 5-nitro-2H-pyrazole-3-carboxylic acid. This compound was then
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f1bc9d97179d3ba082ee85a0e14a730
https://doi.org/10.1021/op300270r
https://doi.org/10.1021/op300270r
Autor:
Robert Francis Kester, Linda Marcus, Marek M. Kabat, Lida Qi, Wang Ka, Michael Pignatello, Wendy Lea Corbett, Cheryl Spence, Franz M. Matschinsky, Lisa M. Garofalo, Roumen Nikolaev Radinov, Ramakanth Sarabu, David J Moore, Yi Ren, Nancy-Ellen Haynes, Zhenmin Liang, Fred Thomas Bizzarro, Darryl W. Hilliard, John Tengi, Wanping Geng, Stanley D. Hutchings, Thomas G. Steele, Joseph Grimsby, Mark T. Dvorozniak, Joseph F. Grippo, Kevin Richard Guertin, Paige Erin Mahaney, Jagdish Kumar Racha
Publikováno v:
Journal of Medicinal Chemistry. 55:7021-7036
Glucokinase (GK) activation as a potential strategy to treat type 2 diabetes (T2D) is well recognized. Compound 1, a glucokinase activator (GKA) lead that we have previously disclosed, caused reversible hepatic lipidosis in repeat-dose toxicology stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aaa5f9f792871c6acf6b9f50fdaa356
https://doi.org/10.1021/jm3008689
https://doi.org/10.1021/jm3008689
Autor:
Roumen Nikolaev Radinov, Andrzej R. Daniewski, Wen Liu, Masami Okabe, Marek M. Kabat, Lisa M. Garofalo, Stanley D. Hutchings, George P. Yiannikouros
Publikováno v:
The Journal of Organic Chemistry. 67:1580-1587
The 1 alpha-hydroxy A-ring phosphine oxide 1, a useful building block for vitamin D analogues, was synthesized from (S)-carvone in nine synthetic operations and a single chromatographic purification in 25% overall yield. The synthesis features two no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fe5c5a814750195adfbe4deb688263
https://doi.org/10.1021/jo0161577
https://doi.org/10.1021/jo0161577
Publikováno v:
Tetrahedron Letters. 41:3303-3307
An unexpectedly low N-9/N-7 regioselectivity was obtained when Robins' reagent (2-N-acetyl-6-O-diphenylcarbamoylguanine) was coupled with a d -glucosamine derivative under trimethylsilyl trifluoromethanesulfonate activation. An unprecedented solvent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fff0f730a823ea415281b51cf5982027
https://doi.org/10.1016/s0040-4039(00)00423-8
https://doi.org/10.1016/s0040-4039(00)00423-8
Publikováno v:
Tetrahedron Letters. 34:277-280
A formal asymmetric synthesis of the anti-obesity drug tetrahydrolipstatin is reported. The advanced intermediate (R)-3-hexyl-5, 6-dihydro-4-hydroxy-6-undexyl-2H-pyran-2-one is prepared in a brief sequence cyclization reaction. The sequence is also u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7288884426f5995fee5ef4e12b05e82
https://doi.org/10.1016/s0040-4039(00)60566-x
https://doi.org/10.1016/s0040-4039(00)60566-x
Publikováno v:
ChemInform. 24
A formal asymmetric synthesis of the anti-obesity drug tetrahydrolipstatin is reported. The advanced intermediate (R)-3-hexyl-5, 6-dihydro-4-hydroxy-6-undexyl-2H-pyran-2-one is prepared in a brief sequence cyclization reaction. The sequence is also u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc186316411c7d1c4d81feb9059b0753
https://doi.org/10.1002/chin.199323200
https://doi.org/10.1002/chin.199323200
Publikováno v:
ChemInform. 31
An unexpectedly low N-9/N-7 regioselectivity was obtained when Robins' reagent (2-N-acetyl-6-O-diphenylcarbamoylguanine) was coupled with a d -glucosamine derivative under trimethylsilyl trifluoromethanesulfonate activation. An unprecedented solvent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd4bc0e90569468fcb47ec784315e29c
https://doi.org/10.1002/chin.200032175
https://doi.org/10.1002/chin.200032175
Autor:
George P. Yiannikouros, Roumen Nikolaev Radinov, Lisa M. Garofalo, Stanley D. Hutchings, Wen Liu, Masami Okabe, Marek M. Kabat, Andrzej R. Daniewski
Publikováno v:
ChemInform. 33
The 1α-hydroxy A-ring phosphine oxide 1, a useful building block for vitamin D analogues, was synthesized from (S)-carvone in nine synthetic operations and a single chromatographic purification in 25% overall yield. The synthesis features two novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4f58eabd7f3c511ed9d60398d28e438
https://doi.org/10.1002/chin.200231191
https://doi.org/10.1002/chin.200231191
Autor:
Wen Liu, Masami Okabe, Marek M. Kabat, Lisa M. Garofalo, Yuefen Zhou, Roumen Nikolaev Radinov, Andrzej R. Daniewski, Stanley D. Hutchings
Publikováno v:
The Journal of organic chemistry. 66(18)
The 1alpha-fluoro A-ring phosphine oxide 1, a useful building block for fluorinated vitamin D analogues, was synthesized from (S)-carvone in 13 synthetic steps, and only five isolations, in 22% overall yield. In the key synthetic step, a highly selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dc1d7690802b0b946e07dc7c24c17d
https://pubmed.ncbi.nlm.nih.gov/11529743
https://pubmed.ncbi.nlm.nih.gov/11529743