Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lisa M. Flick"'
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 117:538-544
A common technique for small-scale isolation of genomic DNA is via adsorption of the DNA molecules onto a silica scaffold. In this work, the isolation capacities of calcium aluminate based glasses were compared against a commercially available silica
Autor:
Erik R. Sampson, Lin Gao, Tian-Fang Li, Edward M. Schwarz, Jennifer H. Jonason, Regis J. O'Keefe, Michael J. Zuscik, Tzong-Jen Sheu, Di Chen, Yrjö T. Konttinen, Lisa M. Flick
Publikováno v:
Arthritis & Rheumatism. 62:2359-2369
Objective To investigate the biologic significance of Smad3 in the progression of osteoarthritis (OA), the crosstalk between Smad3 and activating transcription factor 2 (ATF-2) in the transforming growth factor β (TGFβ) signaling pathway, and the e
Autor:
Edward M. Schwarz, Michael Darowish, Ping Li, Regis J. O'Keefe, Lisa M. Flick, Ra'Kerry Rahman, Jill Gelinas, Susan V. Bukata, Willis Huang
Publikováno v:
Bone. 45:661-668
The goal of this study was to define the anti-osteoclastogenic and/or anti-inflammatory role of IL-6 in inflammatory bone resorption using in vivo and in vitro methods. To this end, titanium particles were placed on murine calvaria, and bone resorpti
Autor:
Edward M. Schwarz, Xiaochao Wei, Xinping Zhang, Regis J. O'Keefe, Hicham Drissi, Lisa M. Flick
Publikováno v:
American Journal of Physiology-Cell Physiology. 297:C310-C320
In prosthetic loosening, bone resorption is induced by wear debris particles generated from the artificial joint articulation. Our prior work showed that synovial-like fibroblasts respond to titanium particles by producing receptor activator of NF-ka
Publikováno v:
MATERIALS TRANSACTIONS. 46:1618-1626
In this work the biocompatibility of two vanadium-free Ti-Al-Nb alloys. Ti-15Al-33Nb and Ti-21Al-29Nb, was evaluated and compared to that for commercially pure titanium (CP Ti) and alumina (Al 2 O 3 ). Fine particles were milled from sheet-processed
Autor:
Edward M. Schwarz, Dirk M. Anderson, Jason M. Weaver, Michael Ulrich-Vinther, Xinping Zhang, Regis J. O'Keefe, Lisa M. Flick, William C. Dougall, Faruk Abuzzahab
Publikováno v:
Journal of Orthopaedic Research. 21:676-684
As dominant regulators of osteoclastogenesis and bone resorption, receptor activator of NFκB (RANK), receptor activator of NFκB ligand, and OPG have been identified as ideal drug targets for the treatment of metabolic bone disease. One concern rega
Autor:
Hani A. Awad, Regis J. O'Keefe, Minjie Zhang, Jennifer H. Jonason, Edward M. Schwarz, Hsin-chiu Ho, Lisa M. Flick, Tzong-Jen Sheu, Matthew D. Breyer
Publikováno v:
Journal of Bone and Mineral Research
As a downstream product of cyclooxygenase 2 (COX-2), prostaglandin E2 (PGE2) plays a crucial role in the regulation of bone formation. It has four different receptor subtypes (EP1 through EP4), each of which exerts different effects in bone. EP2 and
Autor:
Warren C. Hammert, Regis J. O'Keefe, Patrick Basile, Matthew Wolenski, Alayna E. Loiselle, Matthew J. Hilton, Howard N. Langstein, Evan B. Katzel, Lisa M. Flick, Hani A. Awad
Studies were performed evaluating the role of Smad3, a transcription factor mediating canonical TGF-β signaling, on scarring and adhesion formation using an established flexor digitorum longus (FDL) tendon repair model. In unoperated animals the met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ed49712597a665b70966f6d04c58d6
https://europepmc.org/articles/PMC3191491/
https://europepmc.org/articles/PMC3191491/
Autor:
Ryosuke Tsutsumi, Xinping Zhang, Regis J. O'Keefe, Lisa M. Flick, Chao Xie, Xiaochao Wei, Edward M. Schwarz, Minjie Zhang
Periprosthetic osteolysis is the most common cause of aseptic loosening in total joint arthroplasty. The role of inflammatory mediators such as prostaglandin E2 (PGE2) and osteoclast promoting factors including RANKL in the pathogenesis of osteolysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ff678693b1d31a7b40daa1667e06df
https://europepmc.org/articles/PMC2743284/
https://europepmc.org/articles/PMC2743284/
Publikováno v:
Journal of Orthopaedic Research.
During embryonic development, skeletal elements are formed via two distinct processes: intramembranous and endochondral ossification. Several molecular signals coordinating endochondral bone formation have been discovered, including Wnt/β-catenin si