Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Lisa M. Childs"'
Autor:
Regis J. O'Keefe, J. Edward Puzas, Brendan F. Boyce, Dirk M. Anderson, Eleftherios P. Paschalis, Edward M. Schwarz, William C. Dougall, Lisa M. Childs, Adele L. Boskey, Lianping Xing, Randy N. Rosier
Publikováno v:
Journal of Bone and Mineral Research. 17:192-199
Prosthesis failure due to wear debris-induced osteolysis remains a major clinical problem and the greatest limitation for total joint arthroplasty. Based on our knowledge of osteoclast involvement in this process and the requirements of receptor acti
Publikováno v:
Journal of Bone and Mineral Research. 16:338-347
A major limitation of total joint arthroplasty is that up to 20% of patients require revision surgery to correct prosthetic loosening. Aseptic loosening is believed to result from the phagocytosis of wear debris particles by macrophages, which secret
Publikováno v:
The Journal of bone and joint surgery. American volume. 83(12)
Particle phagocytosis by macrophages induces the secretion of tumor necrosis factor-alpha, which is involved in the development of an osteolytic response. Therefore, we aimed to determine whether gene delivery of a soluble inhibitor of tumor necrosis