Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Lisa M. Breckels"'
Autor:
Lisa M. Breckels, Thomas Krueger, Charlotte Hutchings, Charlotte S. Dawson, Kathryn S. Lilley
Publikováno v:
F1000Research, Vol 12 (2024)
Background Expression proteomics involves the global evaluation of protein abundances within a system. In turn, differential expression analysis can be used to investigate changes in protein abundance upon perturbation to such a system. Methods Here,
Externí odkaz:
https://doaj.org/article/af494e36b21e41fe9d82f83176e4cef2
Autor:
Nicola M. Moloney, Konstantin Barylyuk, Eelco Tromer, Oliver M. Crook, Lisa M. Breckels, Kathryn S. Lilley, Ross F. Waller, Paula MacGregor
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract African trypanosomes are dixenous eukaryotic parasites that impose a significant human and veterinary disease burden on sub-Saharan Africa. Diversity between species and life-cycle stages is concomitant with distinct host and tissue tropisms
Externí odkaz:
https://doaj.org/article/4b9d48efa44641b7907a810038aabed8
Autor:
Lisa M. Breckels, Thomas Krueger, Charlotte Hutchings, Charlotte S. Dawson, Kathryn S. Lilley
Publikováno v:
F1000Research, Vol 12 (2023)
Background: Expression proteomics involves the global evaluation of protein abundances within a system. In turn, differential expression analysis can be used to investigate changes in protein abundance upon perturbation to such a system. Methods: Her
Externí odkaz:
https://doaj.org/article/8888ada0ba0141bd95a4e812ae1a0a0c
Autor:
Oliver M. Crook, Colin T. R. Davies, Lisa M. Breckels, Josie A. Christopher, Laurent Gatto, Paul D. W. Kirk, Kathryn S. Lilley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Changes in protein subcellular localization can be determined using mass spectrometry. Here, the authors present a statistical approach to determine relocalising proteins from spatial proteomics experiments.
Externí odkaz:
https://doaj.org/article/2ab3daf7eb8d40e0ab4ad9e1fbd4cdd3
Autor:
Claire M. Mulvey, Lisa M. Breckels, Oliver M. Crook, David J. Sanders, Andre L. R. Ribeiro, Aikaterini Geladaki, Andy Christoforou, Nina Kočevar Britovšek, Tracey Hurrell, Michael J. Deery, Laurent Gatto, Andrew M. Smith, Kathryn S. Lilley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
“Protein relocalisation plays a major role in the innate immune response but remains incompletely characterised. Here, the authors combine temporal proteomics with LOPIT, a spatial proteomic workflow, in a fully Bayesian framework to elucidate spat
Externí odkaz:
https://doaj.org/article/b7981d765ae3484fb2248a1903f40b99
Autor:
John J. H. Shin, Oliver M. Crook, Alicia C. Borgeaud, Jérôme Cattin-Ortolá, Sew Y. Peak-Chew, Lisa M. Breckels, Alison K. Gillingham, Jessica Chadwick, Kathryn S. Lilley, Sean Munro
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The vesicles that transport proteins between intracellular organelles are small, short-lived, and elusive. Here, the authors show that capture of these vesicles through relocalizing tethers to mitochondria allows their contents to be characterised by
Externí odkaz:
https://doaj.org/article/1913f75e498144daac7560db0fab4bbd
Autor:
Aikaterini Geladaki, Nina Kočevar Britovšek, Lisa M. Breckels, Tom S. Smith, Owen L. Vennard, Claire M. Mulvey, Oliver M. Crook, Laurent Gatto, Kathryn S. Lilley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Spatial proteomics allows studying cellular protein localisations at system-wide scale. Here, the authors show that combining the previously developed hyperLOPIT method with differential centrifugation yields protein localisation maps at suborganella
Externí odkaz:
https://doaj.org/article/8cca2d3ddf7e46f093bba2ea911ecc37
Autor:
Clarissa Braccia, Josie A. Christopher, Oliver M. Crook, Lisa M. Breckels, Rayner M. L. Queiroz, Nara Liessi, Valeria Tomati, Valeria Capurro, Tiziano Bandiera, Simona Baldassari, Nicoletta Pedemonte, Kathryn S. Lilley, Andrea Armirotti
Publikováno v:
Cells, Vol 11, Iss 12, p 1938 (2022)
Background: Cystic Fibrosis (CF) is a genetic disorder affecting around 1 in every 3000 newborns. In the most common mutation, F508del, the defective anion channel, CFTR, is prevented from reaching the plasma membrane (PM) by the quality check contro
Externí odkaz:
https://doaj.org/article/f43d0d8f5961427e9e1e630e8999d6ff
Publikováno v:
F1000Research, Vol 8 (2019)
Knowledge of the subcellular location of a protein gives valuable insight into its function. The field of spatial proteomics has become increasingly popular due to improved multiplexing capabilities in high-throughput mass spectrometry, which have ma
Externí odkaz:
https://doaj.org/article/d7510b88022146228ec8cc117d6cbc44
Autor:
Andy Christoforou, Claire M. Mulvey, Lisa M. Breckels, Aikaterini Geladaki, Tracey Hurrell, Penelope C. Hayward, Thomas Naake, Laurent Gatto, Rosa Viner, Alfonso Martinez Arias, Kathryn S. Lilley
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The spatial location of proteins within a cell is a key element of protein function. Here the authors describe hyperLOPIT—a proteomics workflow that allows the simultaneous assignment of thousands of proteins to subcellular niches with high resolut
Externí odkaz:
https://doaj.org/article/94b699fb21c4417090182a6c8cb87d48