Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lisa M. Bergeron"'
Autor:
Scott J. Bowen, Yaqi Zhu, Timothy A. Whitehead, Lisa M. Bergeron, Angélica V Medina-Cucurella
Publikováno v:
Biotechnology and Bioengineering. 115:1925-1937
Nerve growth factor (NGF) plays a central role in multiple chronic pain conditions. As such, anti-NGF monoclonal antibodies (mAbs) that function by antagonizing NGF downstream signaling are leading drug candidates for non-opioid pain relief. To evalu
Autor:
Leszek J. Choromanski, Catherine J. Strietzel, Graeme Bainbridge, Lisa M. Bergeron, Veronica T. Mutchler, Theodore Oliphant
Publikováno v:
Veterinary Immunology and Immunopathology. 158:214-223
Very little is known about the functional properties of feline IgGs. Here we report the in vitro characterization of cloned feline IgGs. Rapid amplification of cDNA ends (RACE) and full-length PCR of cat splenic cDNA were used to identify feline sequ
Autor:
Rachel Blake, Greg J. Fici, Kim M. Summers, Karen Tan, Lisa M. Bergeron, Brendan Corcoran, Victoria MacRae, Greg R. Markby, Rhona Muirhead
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221126 (2019)
Tan, K, Markby, G, Muirhead, R, Blake, R, Bergeron, L, Fici, G J, Summers, K, MacRae, V & Corcoran, B 2019, ' Evaluation of Canine 2D cell cultures as models of myxomatous mitral valve degeneration ', PLoS ONE . https://doi.org/10.1371/journal.pone.0221126
PLoS ONE
Tan, K, Markby, G, Muirhead, R, Blake, R, Bergeron, L, Fici, G J, Summers, K, MacRae, V & Corcoran, B 2019, ' Evaluation of Canine 2D cell cultures as models of myxomatous mitral valve degeneration ', PLoS ONE . https://doi.org/10.1371/journal.pone.0221126
PLoS ONE
The utility of cells cultured from the mitral valve as models of myxomatous diseases needs to be properly validated. In this study valve interstitial cells (VICs) and valve endothelial cells (VECs) were cultured from normal and diseased canine mitral
Publikováno v:
Protein Engineering Design and Selection. 22:607-613
Recombinant proteins often suffer from poor expression because of proteolysis. Existing genetic engineering or fermentation strategies work for only a subset of cases where higher recombinant protein expression is needed. In this paper, we describe t
Publikováno v:
Angewandte Chemie. 121:5776-5779
Publikováno v:
Biotechnology and Bioengineering. 102:1316-1322
Molecular chaperones in aqueous-organic mixtures can broaden the utility of biocatalysis by stabilizing enzymes in denaturing conditions. We have designed a self-renaturing enzyme-chaperone chimera consisting of penicillin amidase and a thermophilic
Publikováno v:
Biochemical and Biophysical Research Communications. 369:707-711
Chaperone function in water-miscible organic co-solvents is useful for biocatalytic applications requiring enzyme stability in semi-aqueous media and for understanding chaperone behavior in hydrophobic environments. Previously, we have shown that a r
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1784:368-378
Molecular chaperones play a central role in maintaining protein structure within a cell. Previously, we determined that the gene encoding a molecular chaperone, a thermosome, from the hyperthermophilic archaeon Methanocaldococcus jannaschii is upregu
Autor:
Bill Dunkle, Steve A. Dunham, Andrea J Gonzales, Lisa M. Bergeron, John A. Shelly, Yaqi Zhu, Graeme Bainbridge, Erin E. McCandless, Sandra Lightle
Publikováno v:
Veterinary immunology and immunopathology. 157(1-2)
To date, very little is known about the functional characteristics of the four published canine IgG subclasses. It is not clear how each subclass engages the immune system via complement-dependent cytotoxicity (CDC) or antibody-dependent cell-mediate
Publikováno v:
Angewandte Chemie (International ed. in English). 48(31)
Unter Spannung: Andert sich in einem Protein-Polymer-Hybridmaterial die mechanische Spannung der Polymermatrix, so lost dies eine Konformationsanderung des Proteinkomplexes aus: Das Material meldet eine strukturelle Schadigung (siehe Bild). Die Repor