Drug Transporter Expression and Localization in Rat Nasal Respiratory and Olfactory Mucosa and Olfactory Bulb: Fig. 1

Autor: Lisa M. Augustine, Nathan J. Cherrington, Mansi Krishan, Mary Beth Genter

Publikováno v: Drug Metabolism and Disposition. 38:1644-1647

Uptake of drugs and other xenobiotics from the nasal cavity and into either the brain or systemic circulation can occur through several different mechanisms, including paracellular transport and movement along primary olfactory nerve axons, which ext

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a153d6bf342e416e0b1f6e7a1a156b9
https://doi.org/10.1124/dmd.110.034611

Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment

Autor: Nathan J. Cherrington, Lisa M. Augustine, Lauren M. Aleksunes, José E. Manautou, George L. Scheffer

Publikováno v: Aleksunes, L M, Augustine, L M, Scheffer, G L, Cherrington, N J & Manautou, J E 2008, ' Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment ', Toxicology, vol. 250, no. 2-3, pp. 82-88 . https://doi.org/10.1016/j.tox.2008.06.009
Toxicology, 250(2-3), 82-88. Elsevier Ireland Ltd

The goal of this study was to identify alterations in mRNA and protein expression of various xenobiotic transport proteins in mouse kidney during cisplatin-induced acute renal failure. For this purpose, male C57BL/6J mice received a single dose of ci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5675dc21b9af04e75fecb048a2452fcc
https://doi.org/10.1016/j.tox.2008.06.009

The Nrf2 Activator Oltipraz Also Activates the Constitutive Androstane Receptor

Autor: Jonathan P. Jackson, Lisa M. Augustine, Wendong Huang, Matthew D. Merrell, Youcai Zhang, Craig D. Fisher, Jonathan M. Maher, Curtis D. Klaassen, Nathan J. Cherrington, David D. Moore, Angela L. Slitt

Publikováno v: Drug Metabolism and Disposition. 36:1716-1721

Oltipraz (OPZ) is a well known inducer of NAD(P)H:quinone oxidoreductase (NQO1) along with other enzymes that comprise the nuclear factor E2-related factor 2 (Nrf2) battery of detoxification genes. However, OPZ treatment also induces expression of CY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c64d2f8274b1a2cd7e1029045b3f4a3
https://doi.org/10.1124/dmd.108.020867

Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease

Autor: Angela L. Slitt, Nathan J. Cherrington, Craig D. Fisher, Lisa M. Augustine, Andrew J. Lickteig, Lauren M. Aleksunes, José E. Manautou, David G. Besselsen

Publikováno v: Drug Metabolism and Disposition. 35:1970-1978

Efflux transporters are responsible for the excretion of numerous xenobiotics and endobiotics and thus play an essential role in proper liver and kidney function. Nonalcoholic fatty liver diseases (NAFLDs) comprise a spectrum of disorders that range

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bd358faecb00ff3fe0c28eefc47293
https://doi.org/10.1124/dmd.107.015107

Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats

Autor: Craig D. Fisher, Robert P. Erickson, Ronald P.J. Oude Elferink, David G. Besselsen, Nathan J. Cherrington, Lisa M. Augustine, Andrew J. Lickteig

Publikováno v: European journal of pharmacology, 613(1-3), 119-127. Elsevier

Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of diagnoses ranging from simple fatty liver (SFL), to non-alcoholic steatohepatitis (NASH). This study aimed to determine the effect of moderate and severe NAFLD on hepatic transporter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17547919e8e44f26176f5b7c7309645
https://pure.amc.nl/en/publications/experimental-nonalcoholic-fatty-liver-disease-results-in-decreased-hepatic-uptake-transporter-expression-and-function-in-rats(593780a3-d665-4562-983b-124183262522).html