Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Lisa M Breckels"'
Autor:
Lisa M. Breckels, Thomas Krueger, Charlotte Hutchings, Charlotte S. Dawson, Kathryn S. Lilley
Publikováno v:
F1000Research, Vol 12 (2024)
Background Expression proteomics involves the global evaluation of protein abundances within a system. In turn, differential expression analysis can be used to investigate changes in protein abundance upon perturbation to such a system. Methods Here,
Externí odkaz:
https://doaj.org/article/af494e36b21e41fe9d82f83176e4cef2
Autor:
Lisa M Breckels, Sean B Holden, David Wojnar, Claire M Mulvey, Andy Christoforou, Arnoud Groen, Matthew W B Trotter, Oliver Kohlbacher, Kathryn S Lilley, Laurent Gatto
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 5, p e1004920 (2016)
Sub-cellular localisation of proteins is an essential post-translational regulatory mechanism that can be assayed using high-throughput mass spectrometry (MS). These MS-based spatial proteomics experiments enable us to pinpoint the sub-cellular distr
Externí odkaz:
https://doaj.org/article/c25995a02a4b4247953bc222acc05e9e
Autor:
Nicola M. Moloney, Konstantin Barylyuk, Eelco Tromer, Oliver M. Crook, Lisa M. Breckels, Kathryn S. Lilley, Ross F. Waller, Paula MacGregor
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract African trypanosomes are dixenous eukaryotic parasites that impose a significant human and veterinary disease burden on sub-Saharan Africa. Diversity between species and life-cycle stages is concomitant with distinct host and tissue tropisms
Externí odkaz:
https://doaj.org/article/4b9d48efa44641b7907a810038aabed8
Autor:
Lisa M. Breckels, Thomas Krueger, Charlotte Hutchings, Charlotte S. Dawson, Kathryn S. Lilley
Publikováno v:
F1000Research, Vol 12 (2023)
Background: Expression proteomics involves the global evaluation of protein abundances within a system. In turn, differential expression analysis can be used to investigate changes in protein abundance upon perturbation to such a system. Methods: Her
Externí odkaz:
https://doaj.org/article/8888ada0ba0141bd95a4e812ae1a0a0c
Autor:
Oliver M. Crook, Colin T. R. Davies, Lisa M. Breckels, Josie A. Christopher, Laurent Gatto, Paul D. W. Kirk, Kathryn S. Lilley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Changes in protein subcellular localization can be determined using mass spectrometry. Here, the authors present a statistical approach to determine relocalising proteins from spatial proteomics experiments.
Externí odkaz:
https://doaj.org/article/2ab3daf7eb8d40e0ab4ad9e1fbd4cdd3
Autor:
Clarissa Braccia, Josie A. Christopher, Oliver M. Crook, Lisa M. Breckels, Rayner M. L. Queiroz, Nara Liessi, Valeria Tomati, Valeria Capurro, Tiziano Bandiera, Simona Baldassari, Nicoletta Pedemonte, Kathryn S. Lilley, Andrea Armirotti
Publikováno v:
Cells, Vol 11, Iss 12, p 1938 (2022)
Background: Cystic Fibrosis (CF) is a genetic disorder affecting around 1 in every 3000 newborns. In the most common mutation, F508del, the defective anion channel, CFTR, is prevented from reaching the plasma membrane (PM) by the quality check contro
Externí odkaz:
https://doaj.org/article/f43d0d8f5961427e9e1e630e8999d6ff
Autor:
Eneko Villanueva, Tom Smith, Mariavittoria Pizzinga, Mohamed Elzek, Rayner M. L. Queiroz, Robert F. Harvey, Lisa M Breckels, Oliver M. Crook, Mie Monti, Veronica Dezi, Anne E. Willis, Kathryn S. Lilley
Existing methods to analyse RNA localisation are constrained to specific RNAs or subcellular niches, precluding the cell-wide mapping of RNA. We present Localisation of RNA (LoRNA), which maps, at once, RNAs to membranous (nucleus, ER and mitochondri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18ea7bab60550bf96333904670f3f038
https://doi.org/10.1101/2022.01.24.477541
https://doi.org/10.1101/2022.01.24.477541
Autor:
Oliver M. Crook, David J. Sanders, Andrew M. Smith, Aikaterini Geladaki, Kathryn S. Lilley, Lisa M. Breckels, Tracey Hurrell, Laurent Gatto, Claire M. Mulvey, Michael J. Deery, André Luis Ribeiro Ribeiro, Andy Christoforou, Nina Kočevar Britovšek
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Protein localisation and translocation between intracellular compartments underlie almost all physiological processes. The hyperLOPIT proteomics platform combines mass spectrometry with state-of-the-art machine learning to map the subcellular locatio
Publikováno v:
Drug discovery today. Technologies. 39
Spatial proteomics has provided important insights into the relationship between protein function and subcellular location. Localization of Organelle Proteins by Isotope Tagging (LOPIT) and its variants are proteome-wide techniques, not matched in sc
Autor:
Simon Butterworth, Ludek Koreny, Tim J. Stevens, Ross F. Waller, Arnab Pain, Lisa M. Breckels, Kathryn S. Lilley, Imen Lassadi, Oliver M. Crook, Vipul Gupta, Tobias Mourier, Eelco C. Tromer, Konstantin Barylyuk, Huiling Ke
Publikováno v:
Cell Host & Microbe, 28(5), 752-766.e9. CELL PRESS
Cell Host & Microbe
Cell Host & Microbe
Summary Apicomplexan parasites cause major human disease and food insecurity. They owe their considerable success to highly specialized cell compartments and structures. These adaptations drive their recognition, nondestructive penetration, and elabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521f92b526a2b2b691e7ed586689268e
https://research.rug.nl/en/publications/4c39e599-339f-4335-a870-e2de9515c5b3
https://research.rug.nl/en/publications/4c39e599-339f-4335-a870-e2de9515c5b3