Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Lisa M, Nicholas"'
Publikováno v:
Metabolites, Vol 11, Iss 8, p 514 (2021)
Early life represents a window of phenotypic plasticity. Thus, exposure of the developing fetus to a compromised nutritional environment can have long term consequences for their health. Indeed, undernutrition or maternal intake of an obesogenic diet
Externí odkaz:
https://doaj.org/article/1b36d8f903ef4f378d819f818454e273
Autor:
Lisa M. Nicholas, Bérengère Valtat, Anya Medina, Lotta Andersson, Mia Abels, Inês G. Mollet, Deepak Jain, Lena Eliasson, Nils Wierup, Malin Fex, Hindrik Mulder
Publikováno v:
Molecular Metabolism, Vol 6, Iss 7, Pp 651-663 (2017)
Objective: Insulin release from pancreatic β-cells is controlled by plasma glucose levels via mitochondrial fuel metabolism. Therefore, insulin secretion is critically dependent on mitochondrial DNA (mtDNA) and the genes it encodes. Mitochondrial tr
Externí odkaz:
https://doaj.org/article/7c8420984bd24f1c94b700a9d5958e76
Autor:
Tessa A. C. Garrud, Noor E. W. D. Teulings, Youguo Niu, Katie L. Skeffington, Christian Beck, Nozomi Itani, Fiona G. Conlon, Kimberley J. Botting, Lisa M. Nicholas, Wen Tong, Jan B. Derks, Susan E. Ozanne, Dino A. Giussani
Antenatal glucocorticoids accelerate fetal lung maturation and reduce mortality in preterm babies but can trigger adverse effects on the cardiovascular system. The mechanisms underlying off-target effects of the synthetic glucocorticoids mostly used,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056475ba0e8e6e80a9958cad80217790
https://www.repository.cam.ac.uk/handle/1810/349413
https://www.repository.cam.ac.uk/handle/1810/349413
Autor:
Shila Ghazanfar, Tony Vuocolo, Janna L Morrison, Lisa M Nicholas, Isabella C McMillen, Jean Y H Yang, Michael J Buckley, Ross L Tellam
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0180378 (2017)
Heritable trait variation within a population of organisms is largely governed by DNA variations that impact gene transcription and protein function. Identifying genetic variants that affect complex functional traits is a primary aim of population ge
Externí odkaz:
https://doaj.org/article/3a856f96fee041c0bcebadbb0c5b5adb
Autor:
Heather L. Blackmore, Emily J. Camm, Noor E. W. D. Teulings, Jan B. Derks, Thomas J. Ashmore, Susan E. Ozanne, Nozomi Itani, Fiona G. Conlon, Kimberley J. Botting, Katie L. Skeffington, Lisa M. Nicholas, Angela Logan, Youguo Niu, Dino A. Giussani, Michael P. Murphy, Tessa A. C. Garrud, Christian Beck, Wen Tong
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Antenatal glucocorticoid therapy reduces mortality in the preterm infant, but evidence suggests off-target adverse effects on the developing cardiovascular system. Whether deleterious effects are direct on the offspring or secondary to alterations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c05979be75670c07a6b47a1bc10e27
http://europepmc.org/articles/PMC7611332
http://europepmc.org/articles/PMC7611332
Autor:
Lisa M. Nicholas, Michael P. Murphy, Thomas J. Ashmore, Katie L. Skeffington, Susan E. Ozanne, Megan R. Sutherland, Dino A. Giussani, Emily J. Camm, Youguo Niu, Shani Austin-Williams, Ana-Mishel Spiroski, Angela Logan
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Mitochondria-derived oxidative stress during fetal development increases cardiovascular risk in adult offspring of pregnancies complicated by chronic fetal hypoxia. We investigated the efficacy of the mitochondria-targeted antioxidant MitoQ in preven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42909fbb0e9dd8d64e2175e6d9b826d2
Autor:
Lisa M Nicholas, Janna L Morrison, Leewen Rattanatray, Susan E Ozanne, Dave O Kleemann, Simon K Walker, Severence M MacLaughlin, Song Zhang, Malgorzata S Martin-Gronert, Isabella C McMillen
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84594 (2013)
Exposure to maternal obesity before and/or throughout pregnancy may increase the risk of obesity and insulin resistance in the offspring in childhood and adult life, therefore, resulting in its transmission into subsequent generations. We have previo
Externí odkaz:
https://doaj.org/article/0c29acf78be2416d8435aff36e1c186c
Autor:
Vladimir V. Sharoyko, Hindrik Mulder, Neelanjan Vishnu, Anya Medina, David G. Nicholls, Peter Spégel, Lisa M. Nicholas, Malin Fex
Publikováno v:
Journal of Endocrinology. 236:R145-R159
Mitochondrial metabolism is a major determinant of insulin secretion from pancreatic β-cells. Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in response to glucose. This results in hyperglycemia and metabolic dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ae350e968a70db2729aebb66cc4761
https://doi.org/10.1530/joe-17-0367
https://doi.org/10.1530/joe-17-0367
Publikováno v:
Metabolites, Vol 11, Iss 514, p 514 (2021)
Metabolites
Metabolites
Early life represents a window of phenotypic plasticity. Thus, exposure of the developing fetus to a compromised nutritional environment can have long term consequences for their health. Indeed, undernutrition or maternal intake of an obesogenic diet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcbdad1322067d8b68c9bcea1ea06ff
https://doi.org/10.3390/metabo11080514
https://doi.org/10.3390/metabo11080514
Autor:
Inês G. Mollet, Malin Fex, Lisa M. Nicholas, Bérengère Valtat, Nils Wierup, Lena Eliasson, Mia Abels, Deepak Jain, Hindrik Mulder, Lotta Andersson, Anya Medina
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 7, Pp 651-663 (2017)
Molecular Metabolism, Vol 6, Iss 7, Pp 651-663 (2017)
Objective Insulin release from pancreatic β-cells is controlled by plasma glucose levels via mitochondrial fuel metabolism. Therefore, insulin secretion is critically dependent on mitochondrial DNA (mtDNA) and the genes it encodes. Mitochondrial tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83dcd7ba5105a325832e60c6a31d48dc
https://doi.org/10.1016/j.molmet.2017.05.005
https://doi.org/10.1016/j.molmet.2017.05.005