Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lisa M, Massoudi"'
Autor:
Elizabeth A. Wynn, Christian Dide-Agossou, Matthew Reichlen, Karen Rossmassler, Reem Al Mubarak, Justin J. Reid, Samuel T. Tabor, Sarah E. M. Born, Monica R. Ransom, Rebecca M. Davidson, Kendra N. Walton, Jeanne B. Benoit, Amanda Hoppers, Dorothy E. Loy, Allison A. Bauman, Lisa M. Massoudi, Gregory Dolganov, Michael Strong, Payam Nahid, Martin I. Voskuil, Gregory T. Robertson, Camille M. Moore, Nicholas D. Walter
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTTo address the ongoing global tuberculosis crisis, there is a need for shorter, more effective treatments. A major reason why tuberculosis requires prolonged treatment is that, following a short initial phase of rapid killing, the residual My
Externí odkaz:
https://doaj.org/article/ecb358dada2541348c703fab9ae27766
Autor:
Elizabeth A Wynn, Christian Dide-Agossou, Matthew Reichlen, Karen Rossmassler, Reem Al Mubarak, Justin J Reid, Samuel T Tabor, Sarah E M Born, Monica R Ransom, Rebecca M Davidson, Kendra N Walton, Jeanne B Benoit, Amanda Hoppers, Allison A Bauman, Lisa M Massoudi, Gregory Dolganov, Payam Nahid, Martin I Voskuil, Gregory T Robertson, Camille M Moore, Nicholas D Walter
Publikováno v:
bioRxiv
Transcriptome evaluation ofMycobacterium tuberculosisin the lungs of laboratory animals during long-term treatment has been limited by extremely low abundance of bacterial mRNA relative to eukaryotic RNA. Here we report a targeted amplification RNA s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e2c2e859c82343e0141de70a2bed1d
https://europepmc.org/articles/PMC10028792/
https://europepmc.org/articles/PMC10028792/
Autor:
Nicholas D. Walter, Jackie P. Ernest, Christian Dide-Agossou, Allison A. Bauman, Michelle E. Ramey, Karen Rossmassler, Lisa M. Massoudi, Samantha Pauly, Reem Al Mubarak, Martin I. Voskuil, Firat Kaya, Jansy P. Sarathy, Matthew D. Zimmerman, Véronique Dartois, Brendan K. Podell, Radojka M. Savic, Gregory T. Robertson
Tuberculosis lung lesions are complex and harbor heterogeneous microenvironments that influence antibiotic effectiveness. Major strides have been made recently in understanding drug pharmacokinetics in pulmonary lesions, but the bacterial phenotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32c2774e6ba237d4dcbaa51a1145d6af
https://doi.org/10.1101/2023.02.03.527062
https://doi.org/10.1101/2023.02.03.527062
Autor:
Stephen Fienberg, Gregory S. Basarab, Anne J. Lenaerts, Virsinha Reddy, Sandeep R. Ghorpade, Mathew Njoroge, Grant A. Boyle, Charles J. Eyermann, Clifton E. Barry, Timothy G. Myers, Efrem Abay, Nina Lawrence, Alissa Myrick, Helena I. Boshoff, Vinayak Singh, Lutete Peguy Khonde, Lisa M. Massoudi, Paul D. van Helden, Frederick A. Sirgel, Gregory T. Robertson, Rudolf Müller, Kelly Chibale, Aloysius T. Nchinda, Qin Su
Publikováno v:
Journal of Medicinal Chemistry. 64:12790-12807
Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against Mycobacterium tuberculosis (Mtb) in cholesterol-containing media identified 1,3-diarylpyrazolyl-acylsulfonamide 1 as a moderately active hit. Structure-a
Autor:
Tanya Parish, Lindsay Flint, Anuradha Kumar, Lisa M. Massoudi, Paul Scullion, Gregory T. Robertson, Shilah A. Bonnett, Simon Green, Nicola Caldwell, Jennifer Riley, Gail M. Freiberg, Philip Arthur Hipskind, Michael Mathieson, Thierry Masquelin, Laste Stojanovski, Curtis A. Engelhart, Margaret Huggett, Dinakaran Murugesan, Abraham Lopez Moure, Fabio Zuccotto, Julie V. Early, Ola Epemolu, Paul G. Wyatt, Dale J. Kempf, Kevin D. Read, Susan Davis, Laura A. T. Cleghorn, James Johnson, Steven Mullen, Malcolm Taylor, Anne J. Lenaerts, Penelope A. Turner, Peter C. Ray, Joshua Odingo, Dirk Schnappinger, Aaron Korkegian, Douglas Joerss
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
ACS Omega, Vol 6, Iss 3, Pp 2284-2311 (2021)
With the emergence of multi-drug-resistant strains of Mycobacterium tuberculosis, there is a pressing need for new oral drugs with novel mechanisms of action. A number of scaffolds with potent anti-tubercular in vitro activity have been identified fr
Autor:
Gregory S. Basarab, Sandeep Ghorpade, Liezl Gibhard, Rudolf Mueller, Mathew Njoroge, Nashied Peton, Preshendren Govender, Lisa M. Massoudi, Gregory Thomas Robertson, Anne J. Lenaerts, Helena Ingrid Boshoff, Douglas Joerss, Tanya Parish, Thomas F. Durand-Reville, Manos Perros, Vinayak Singh, Kelly Chibale
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
Described here is a series of spiropyrimidinetrione (SPT) compounds with activity against Mycobacterium tuberculosis through inhibition of DNA gyrase. The SPT class operates via a novel mode of inhibition, which involves Mg 2+ -independent stabilizat
Autor:
Caroline Wilson, Peter Ray, Fabio Zuccotto, Jorge Hernandez, Anup Aggarwal, Claire Mackenzie, Nicola Caldwell, Malcolm Taylor, Margaret Huggett, Michael Mathieson, Dinakaran Murugesan, Alasdair Smith, Susan Davis, Mattia Cocco, Maloy K. Parai, Arjun Acharya, Fabio Tamaki, Paul Scullion, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Eva Maria Lopez-Román, Pedro Alfonso Torres-Gómez, Ana Maria Toledo, Laura Guijarro-Lopez, Isabel Camino, Curtis A. Engelhart, Dirk Schnappinger, Lisa M. Massoudi, Anne Lenaerts, Gregory T. Robertson, Chris Walpole, David Matthews, David Floyd, James C. Sacchettini, Kevin D. Read, Lourdes Encinas, Robert H. Bates, Simon R. Green, Paul G. Wyatt
Publikováno v:
Journal of Medicinal Chemistry
With increasing drug resistance in tuberculosis (TB) patient populations, there is an urgent need for new drugs. Ideally, new agents should work through novel targets so that they are unencumbered by preexisting clinical resistance to current treatme
Autor:
Mike A. Lyons, Barbara Graham, Ekaterina Maidj, Anne J. Lenaerts, Dashick W. L. Scott, Franceen Eshun-Wilson, Matt Zimmerman, Gregory T. Robertson, Michelle E. Ramey, Brendan K. Podell, Véronique Dartois, Firat Kaya, Bryce C. Asay, Courtney Hastings, Lisa M. Massoudi, Joshua Vasquez, Lisa K. Woolhiser, Veronica Gruppo, Claire L. Carter
Publikováno v:
Antimicrobial Agents and Chemotherapy
Multiple drug discovery initiatives for tuberculosis are currently ongoing to identify and develop new potent drugs with novel targets in order to shorten treatment duration. One of the drug classes with a new mode of action is DprE1 inhibitors targe
Autor:
Lutete Peguy, Khonde, Rudolf, Müller, Grant A, Boyle, Virsinha, Reddy, Aloysius T, Nchinda, Charles J, Eyermann, Stephen, Fienberg, Vinayak, Singh, Alissa, Myrick, Efrem, Abay, Mathew, Njoroge, Nina, Lawrence, Qin, Su, Timothy G, Myers, Helena I M, Boshoff, Clifton E, Barry, Frederick A, Sirgel, Paul D, van Helden, Lisa M, Massoudi, Gregory T, Robertson, Anne J, Lenaerts, Gregory S, Basarab, Sandeep R, Ghorpade, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry. 64(17)
Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against
Autor:
Lisa M. Massoudi, Elizabeth Creissen, Anne J. Lenaerts, Andrés Obregón-Henao, Kimberly A. Arnett, Koen Andries, Diane J. Ordway, Marcela Henao-Tamayo
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:6904-6912
Over the last 10 years, Mycobacterium abscessus group strains have emerged as important human pathogens, which are associated with significantly higher fatality rates than any other rapidly growing mycobacteria. These opportunistic pathogens are wide