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A novel approach for measuring room temperature enthalpy of mixing and associated solubility estimation of a drug in a polymer matrix

Autor: Haichen Nie, Patrick J. Marsac, Yongchao Su, Hang Lau, Nico Setiawan, Lynne S. Taylor, Matthew K. Defrese, Jonas Alin, James DiNunzio, Hanmi Xi, Nathan Hesse, Lisa Lupton

Publikováno v: Polymer. 135:50-60

The utility of amorphization of drug molecules, such as enhanced solubility, dissolution rate and oral bioavailability, has been well exemplified in the literature. Yet, the application of this technique is often hindered by the crystallization liabi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2579c68485d1841a71e5ed4bbec19b5a
https://doi.org/10.1016/j.polymer.2017.11.056

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Formulating Weakly Basic HCl Salts: Relative Ability of Common Excipients to Induce Disproportionation and the Unique Deleterious Effects of Magnesium Stearate

Autor: Wei Xu, Christopher T. John, Paul A. Harmon, Lisa Lupton

Publikováno v: Pharmaceutical Research. 30:1628-1641

Nine common excipients were examined to determine their ability to cause disproportionation of the HCl salt of a a weakly basic compound. The goal was to determine which excipients were problematic and correlate the results to known properties such a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332348d119c46efcc2ca1487e0a5dea5
https://doi.org/10.1007/s11095-013-1002-y

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