Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Lisa L. Wilson"'
Autor:
Lisa L. Wilson, Amy R. Alleyne, Shainnel O. Eans, Thomas J. Cirino, Heather M. Stacy, Marco Mottinelli, Sebastiano Intagliata, Christopher R. McCurdy, Jay P. McLaughlin
Publikováno v:
Molecules, Vol 27, Iss 11, p 3617 (2022)
Sigma receptors modulate nociception, offering a potential therapeutic target to treat pain, but relatively little is known regarding the role of sigma-2 receptors (S2R) in nociception. The purpose of this study was to investigate the in vivo analges
Externí odkaz:
https://doaj.org/article/b52e94dd1a3a49688fc681766bfc0bd2
Autor:
Lisa L. Wilson, Shainnel O. Eans, Insitar Ramadan-Siraj, Maria N. Modica, Giuseppe Romeo, Sebastiano Intagliata, Jay P. McLaughlin
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 615 (2022)
Neuropathic pain is a significant problem with few effective treatments lacking adverse effects. The sigma-1 receptor (S1R) is a potential therapeutic target for neuropathic pain, as antagonists for this receptor effectively ameliorate pain in both p
Externí odkaz:
https://doaj.org/article/d97729e03dc2455194ca864b9d0e0e7a
Autor:
Thomas J. Cirino, Shainnel O. Eans, Jessica M. Medina, Lisa L. Wilson, Marco Mottinelli, Sebastiano Intagliata, Christopher R. McCurdy, Jay P. McLaughlin
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Sigma-1 receptors (S1R) and sigma-2 receptors (S2R) may modulate nociception without the liabilities of opioids, offering a promising therapeutic target to treat pain. The purpose of this study was to investigate the in vivo analgesic and anti-allody
Externí odkaz:
https://doaj.org/article/3a6d16ca430e49cab94ae69862831961
Autor:
Bronwyn M. Kivell, Shainnel O. Eans, Abdullah Allaoa, András Váradi, Lisa L. Wilson, Gavril W. Pasternak, Rajendra Uprety, Andrew C. Kruegel, John E. Pintar, Xiaohai Li, Samuel T. Slocum, Takeshi Irie, Jay P. McLaughlin, Brittany Scouller, Amy F. Alder, Michael D. Cameron, Sanjay Kalra, Ying-Xian Pan, Amanda Hunkele, Susruta Majumdar, Michael Ansonoff, Valerie Le Rouzic, Dalibor Sames, Soumen Chakraborty, Jin Xu
Publikováno v:
J Med Chem
The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of natural products chemistry, chemical synthesis, and pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c5e470bfb54471841442c42450dcbe
https://doi.org/10.1021/acs.jmedchem.1c01111
https://doi.org/10.1021/acs.jmedchem.1c01111
Autor:
Valeria Pittalà, Giuseppe Romeo, Lisa L. Wilson, Federica Bonanno, Loredana Salerno, Maria N. Modica, Sebastiano Intagliata, Orazio Prezzavento, Jay P. McLaughlin, Emanuela Arena
Publikováno v:
ACS Chemical Neuroscience
σ-1 receptors (σ1R) modulate nociceptive signaling, driving the search for selective antagonists to take advantage of this promising target to treat pain. In this study, a new series of benzylpiperazinyl derivatives has been designed, synthesized,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0491f2ec83a8cb1f12791d25124f6b6
https://doi.org/10.1021/acschemneuro.1c00106
https://doi.org/10.1021/acschemneuro.1c00106
Autor:
Heather M. Stacy, Susruta Majumdar, Soumen Chakraborty, Jay P. McLaughlin, Lisa L. Wilson, Rajendra Uprety, Chloe A. Simons, Shainnel O. Eans, Thomas J. Cirino
Publikováno v:
Cell Mol Neurobiol
Chronic administration of opioids produces physical dependence and opioid-induced hyperalgesia. Users claim the Thai traditional tea “Kratom” and component alkaloid mitragynine ameliorate opioid withdrawal without increased sensitivity to pain. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce02cf6473ee07a813168eeccf67e9a
https://doi.org/10.1007/s10571-020-01034-7
https://doi.org/10.1007/s10571-020-01034-7
Autor:
Thomas F. Murray, Jeremy S. Coleman, Lisa L. Wilson, Jay P. McLaughlin, Shainnel O. Eans, Grant G. Simpson, Heather M. Stacy, Jane V. Aldrich, Ariana C. Brice-Tutt, Michael J. Ferracane
Publikováno v:
ACS Chemical Neuroscience. 11:1324-1336
Substance abuse remains a serious public health crisis, affecting millions of people worldwide. Macrocyclic tetrapeptides like CJ-15,208 and [d-Trp]CJ-15,208 demonstrate opioid activity shown to attenuate the rewarding effects of cocaine in condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac49a9dfa24622bcb3cff736f88e7fa9
https://doi.org/10.1021/acschemneuro.0c00086
https://doi.org/10.1021/acschemneuro.0c00086
Autor:
Chloe A. Simons, Michael J. Ferracane, Jeremy S. Coleman, Jay P. McLaughlin, Jane V. Aldrich, Ariana C. Brice-Tutt, Heather M. Stacy, Lisa L. Wilson, Grant G. Simpson, Shainnel O. Eans
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: The macrocyclic tetrapeptide natural product CJ‐15,208 (cyclo[Phe‐d‐Pro‐Phe‐Trp]) is a multifunctional μ‐opioid receptor and κ‐opioid receptor agonist and κ‐opioid receptor antagonist that produces antinocic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9fe153a942f68226d86b685201a7f1b
https://europepmc.org/articles/PMC7443475/
https://europepmc.org/articles/PMC7443475/
Autor:
Frederick T. Chin, Lisa L. Wilson, Abhisheak Sharma, Tamara I. King, Bonnie A. Avery, Sebastiano Intagliata, Rae R. Matsumoto, Jay P. McLaughlin, Michael J. Seminerio, Christopher R. McCurdy, Christophe Mesangeau
Publikováno v:
The AAPS journal. 22(5)
The sigma-2 receptor has been cloned and identified as Tmem97, which is a transmembrane protein involved in intracellular Ca2+ regulation and cholesterol homeostasis. Since its discovery, the sigma-2 receptor has been an extremely controversial targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8853e9758528ac51ac931c0abe100092
https://pubmed.ncbi.nlm.nih.gov/32691179
https://pubmed.ncbi.nlm.nih.gov/32691179
Autor:
Michael J, Ferracane, Ariana C, Brice-Tutt, Jeremy S, Coleman, Grant G, Simpson, Lisa L, Wilson, Shainnel O, Eans, Heather M, Stacy, Thomas F, Murray, Jay P, McLaughlin, Jane V, Aldrich
Publikováno v:
ACS chemical neuroscience. 11(9)
Substance abuse remains a serious public health crisis, affecting millions of people worldwide. Macrocyclic tetrapeptides like CJ-15,208 and [d-Trp]CJ-15,208 demonstrate opioid activity shown to attenuate the rewarding effects of cocaine in condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6cc0a49dcb2bb5416ddcdcf5f68abc2
https://pubmed.ncbi.nlm.nih.gov/32251585
https://pubmed.ncbi.nlm.nih.gov/32251585