In vivo dopaminergic and behavioral responses to acute cocaine are altered in adenosine A2A receptor knockout mice

Autor: Jolanta Opacka-Juffry, Ian Kitchen, Donald D. Fisher, Lisa L. Wells, Catherine Ledent, Susanna M.O. Hourani

Publikováno v: Synapse. 66:383-390

Adenosine, acting on A(2A) adenosine receptors, regulates addictive processes induced by drugs of abuse. The present study investigates the role of A(2A) adenosine receptors in neurochemical and behavioural responses to an acute cocaine challenge. Ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5833c40631ed72fdd387eaaab13b8828
https://doi.org/10.1002/syn.21527

Metabotropic mGluR5- and adenosine A2A-receptor interactions in opioid addiction

Autor: Ream Al-Hasani, Ian Kitchen, Sherie Rose Smith, Alexis Bailey, Nicole Pochani, Lisa L. Wells, Susanna M.O. Hourani

Publikováno v: Pharmacological Reports. 63:225

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d6bceacf735a5e76f2cb7d624dc7859
https://doi.org/10.1016/s1734-1140(11)70443-1

Subcutaneous white adipose tissue independently regulates burn-induced hypermetabolism via immune-adipose crosstalk.

Autor: Knuth CM; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada; Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada., Barayan D; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada; Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada., Lee JH; Translational Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4 Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Auger C; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA., de Brito Monteiro L; David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, ON L8L 2X2, Canada., Ricciuti Z; Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada., Metko D; Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada., Wells L; Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada., Sung HK; Translational Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4 Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Screaton RA; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada; Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada., Jeschke MG; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada; David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, ON L8L 2X2, Canada; Hamilton General Hospital, Hamilton Health Sciences, Hamilton, ON L8L 2X2, Canada; Department of Surgery, McMaster University, Hamilton, ON L8S 4K1, Canada. Electronic address: jeschke@hhsc.ca.

Publikováno v: Cell reports [Cell Rep] 2024 Jan 23; Vol. 43 (1), pp. 113584. Date of Electronic Publication: 2023 Dec 20.

Reactive Oxygen Species Modulator 1 Plays an Obligate Role in Cardiomyocyte Hypertrophy.

Autor: Martens MD; Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Alberta Diabetes Institute (M.D.M., H.L.S., D.Y.M.-L., M.K.,.M.F., J.R.U., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Department of Pediatrics (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., S.L.B., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada., Holody CD; Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Department of Pediatrics (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., S.L.B., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Department of Medicine (C.D.H., H.C., H.L., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Department of Anesthesiology (C.D.H., S.L.B.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada., Wells L; Sunnybrook Research Institute (L.W., W.W.D., C.R., B.B.Y., R.A.S.), University of Toronto, Ontario, Canada.; Department of Biochemistry (L.W., C.R., R.A.S.), University of Toronto, Ontario, Canada., Silver HL; Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Alberta Diabetes Institute (M.D.M., H.L.S., D.Y.M.-L., M.K.,.M.F., J.R.U., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Department of Pediatrics (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., S.L.B., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada., Morales-Llamas DY; Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Alberta Diabetes Institute (M.D.M., H.L.S., D.Y.M.-L., M.K.,.M.F., J.R.U., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Department of Pediatrics (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., S.L.B., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada., Du WW; Sunnybrook Research Institute (L.W., W.W.D., C.R., B.B.Y., R.A.S.), University of Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology (W.W.D., B.B.Y.), University of Toronto, Ontario, Canada., Reeks C; Sunnybrook Research Institute (L.W., W.W.D., C.R., B.B.Y., R.A.S.), University of Toronto, Ontario, Canada.; Department of Biochemistry (L.W., C.R., R.A.S.), University of Toronto, Ontario, Canada., Khairy M; Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Alberta Diabetes Institute (M.D.M., H.L.S., D.Y.M.-L., M.K.,.M.F., J.R.U., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Department of Pediatrics (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., S.L.B., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada., Chen H; Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada., Ferdaoussi M; Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Alberta Diabetes Institute (M.D.M., H.L.S., D.Y.M.-L., M.K.,.M.F., J.R.U., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Faculty Saint-Jean (M.F., H.L.), University of Alberta, Edmonton, Canada., Bourque SL; Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Department of Pediatrics (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., S.L.B., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Department of Medicine (C.D.H., H.C., H.L., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Department of Anesthesiology (C.D.H., S.L.B.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada., Yang BB; Sunnybrook Research Institute (L.W., W.W.D., C.R., B.B.Y., R.A.S.), University of Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology (W.W.D., B.B.Y.), University of Toronto, Ontario, Canada., Ussher JR; Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Alberta Diabetes Institute (M.D.M., H.L.S., D.Y.M.-L., M.K.,.M.F., J.R.U., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Faculty of Pharmacy and Pharmaceutical Sciences (J.R.U.), University of Alberta, Edmonton, Canada., Lemieux H; Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Department of Medicine (C.D.H., H.C., H.L., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Faculty Saint-Jean (M.F., H.L.), University of Alberta, Edmonton, Canada., Oudit GY; Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Department of Medicine (C.D.H., H.C., H.L., G.Y.O.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada., Screaton RA; Sunnybrook Research Institute (L.W., W.W.D., C.R., B.B.Y., R.A.S.), University of Toronto, Ontario, Canada.; Department of Biochemistry (L.W., C.R., R.A.S.), University of Toronto, Ontario, Canada., Dyck JRB; Cardiovascular Research Centre (M.D.M., H.L.S., D.Y.M.-L., M.K., H.C., M.F., J.R.U., G.Y.O., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Alberta Diabetes Institute (M.D.M., H.L.S., D.Y.M.-L., M.K.,.M.F., J.R.U., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Women and Children's Health Research Institute (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., M.F., S.L.B., J.R.U., H.L., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.; Department of Pediatrics (M.D.M., C.D.H., H.L.S., D.Y.M.-L., M.K., S.L.B., J.R.B.D.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.

Publikováno v: Circulation research [Circ Res] 2024 Jan 05; Vol. 134 (1), pp. 114-116. Date of Electronic Publication: 2023 Nov 29.

Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation.

Autor: Iorio C; Sunnybrook Research Institute, Toronto, Canada., Rourke JL; Sunnybrook Research Institute, Toronto, Canada.; Mount Allison University, Sackville, NB, Canada., Wells L; Sunnybrook Research Institute, Toronto, Canada., Sakamaki JI; Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan., Moon E; Sunnybrook Research Institute, Toronto, Canada.; Department of Biochemistry, University of Toronto, Toronto, Canada., Hu Q; Sunnybrook Research Institute, Toronto, Canada., Kin T; Clinical Islet Laboratory, University of Alberta Hospital, Edmonton, Canada., Screaton RA; Sunnybrook Research Institute, Toronto, Canada. robert.screaton@sri.utoronto.ca.; Department of Biochemistry, University of Toronto, Toronto, Canada. robert.screaton@sri.utoronto.ca.

Publikováno v: Communications biology [Commun Biol] 2021 Jul 23; Vol. 4 (1), pp. 907. Date of Electronic Publication: 2021 Jul 23.