ROS Scavenger, Ebselen, Has No Preventive Effect in New Hearing Loss Model Using a Cholesterol-Chelating Agent

Autor: R. Keith Duncan, Lisa L. Kabara, Donald L. Swiderski, Young Ho Kim, Yehoash Raphael, Min Young Lee

Publikováno v: Journal of Audiology & Otology

Background and objectives The antioxidant ebselen will be able to limit or prevent the ototoxicity arising from 2-hydroxypropyl-β-cyclodextrin (HPβCD). Niemann-Pick Type C (NPC) disease is a disorder of lysosomal storage manifested in sphingolipido

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8259174d55835623f27e0c4dbfcc13c7
http://europepmc.org/articles/PMC6468279

Hair Cell Loss, Spiral Ganglion Degeneration, and Progressive Sensorineural Hearing Loss in Mice with Targeted Deletion of Slc44a2/Ctl2

Autor: Bala Naveen Kakaraparthi, Thankam S. Nair, Kelli Rule, Susan G. Fisher, Mark J. Hoenerhoff, Trey B. Thomas, Lisa L. Kabara, Richard A. Altschuler, Lillian Lu, Thomas L. Saunders, David F. Dolan, Maria M. Galano, Thomas E. Carey, Ariane Kanicki, Danielle M. Miller, Pavan K. Kommareddi, Elizabeth D. Hughes, Irina Laczkovich, David C. Kohrman, Julie M. Jones

Publikováno v: JARO: Journal of the Association for Research in Otolaryngology

SLC44A2 (solute carrier 44a2), also known as CTL2 (choline transporter-like protein 2), is expressed in many supporting cell types in the cochlea and is implicated in hair cell survival and antibody-induced hearing loss. In mice with the mixed C57BL/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fc7acde5eca4bb1d0b6f0da6bec03c
https://doi.org/10.1007/s10162-015-0547-3

Ototoxicity-induced loss of hearing and inner hair cells is attenuated by HSP70 gene transfer

Autor: Lisa L. Kabara, Yohei Takada, Donald L. Swiderski, Tomoko Takada, Yehoash Raphael, David F. Dolan, Min Young Lee

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 2, Iss, Pp-(2015)
Molecular Therapy. Methods & Clinical Development

The most common reason for sensorineural deafness is death of hair cells (HCs). Heat shock proteins (HSPs) are molecular chaperones that participate in folding, targeting, and degrading proteins. HSP expression is increased in response to various env

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a944fa7168a68ee769342d450ef9bb

Loss of the chromatin remodeler CHD7 impacts glial cells and myelination in the mouse cochlear spiral ganglion.

Autor: Ritter KE; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA., Lynch SM; College of Literature, Science and Art, University of Michigan, Ann Arbor, MI, USA., Gorris AM; College of Literature, Science and Art, University of Michigan, Ann Arbor, MI, USA., Beyer LA; Department of Otolaryngology - Head and Neck Surgery, University of Medical School, Ann Arbor, MI, USA., Kabara L; Department of Otolaryngology - Head and Neck Surgery, University of Medical School, Ann Arbor, MI, USA., Dolan DF; Department of Otolaryngology - Head and Neck Surgery, University of Medical School, Ann Arbor, MI, USA., Raphael Y; Department of Otolaryngology - Head and Neck Surgery, University of Medical School, Ann Arbor, MI, USA., Martin DM; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: donnamm@med.umich.edu.

Publikováno v: Hearing research [Hear Res] 2022 Dec; Vol. 426, pp. 108633. Date of Electronic Publication: 2022 Oct 13.

Rapamycin Added to Diet in Late Mid-Life Delays Age-Related Hearing Loss in UMHET4 Mice.

Autor: Altschuler RA; Kresge Hearing Research Institute, Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, MI, United States.; VA Ann Arbor Health Care System, Ann Arbor, MI, United States.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, United States., Kabara L; Kresge Hearing Research Institute, Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, MI, United States., Martin C; Kresge Hearing Research Institute, Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, MI, United States., Kanicki A; Kresge Hearing Research Institute, Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, MI, United States., Stewart CE; Kresge Hearing Research Institute, Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, MI, United States.; VA Ann Arbor Health Care System, Ann Arbor, MI, United States., Kohrman DC; Kresge Hearing Research Institute, Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, MI, United States., Dolan DF; Kresge Hearing Research Institute, Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, MI, United States.

Publikováno v: Frontiers in cellular neuroscience [Front Cell Neurosci] 2021 Apr 07; Vol. 15, pp. 658972. Date of Electronic Publication: 2021 Apr 07 (Print Publication: 2021).