MND1 enables homologous recombination in somatic cells primarily outside the context of replication

Autor: Lisa Koob, Anoek Friskes, Louise vanBergen, Femke M. Feringa, Bram van denBroek, Emma S. Koeleman, Ellis vanBeek, Michael Schubert, Vincent A. Blomen, Thijn R. Brummelkamp, Lenno Krenning, René H. Medema

Publikováno v: Molecular Oncology, Vol 17, Iss 7, Pp 1192-1211 (2023)

Faithful and timely repair of DNA double‐strand breaks (DSBs) is fundamental for the maintenance of genomic integrity. Here, we demonstrate that the meiotic recombination co‐factor MND1 facilitates the repair of DSBs in somatic cells. We show tha

Externí odkaz: https://doaj.org/article/e82d5294e0a84e3596d187a3bb227b86

Double-strand break toxicity is chromatin context independent

Autor: Anoek Friskes, Lisa Koob, Lenno Krenning, Tesa M Severson, Emma S Koeleman, Xabier Vergara, Michael Schubert, Jeroen van den Berg, Bastiaan Evers, Anna G Manjón, Stacey Joosten, Yongsoo Kim, Wilbert Zwart, René H Medema

Publikováno v: Friskes, A, Koob, L, Krenning, L, Severson, T M, Koeleman, E S, Vergara, X, Schubert, M, van den Berg, J, Evers, B, Manjón, A G, Joosten, S, Kim, Y, Zwart, W & Medema, R H 2022, ' Double-strand break toxicity is chromatin context independent ', Nucleic Acids Research, vol. 50, no. 17, pp. 9930-9947 . https://doi.org/10.1093/nar/gkac758
Nucleic Acids Research, 50(17), 9930-9947. Oxford University Press

Cells respond to double-strand breaks (DSBs) by activating DNA damage response pathways, including cell cycle arrest. We have previously shown that a single double-strand break generated via CRISPR/Cas9 is sufficient to delay cell cycle progression a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3aa9f1cdbb010bdf6fb2581f0314d44
https://doi.org/10.1093/nar/gkac758

MND1 enables repair of two-ended DNA double-strand breaks

Autor: Lisa Koob, Anoek Friskes, Louise van Bergen, Femke M. Feringa, Bram van den Broek, Emma S. Koeleman, Michael Schubert, Vincent A. Blomen, Thijn R. Brummelkamp, Lenno Krenning, René H. Medema

SummaryFaithful and timely repair of DNA double-strand breaks (DSBs) is fundamental for the maintenance of genomic integrity. Here, we demonstrate that the meiotic recombination co-factor MND1 facilitates the repair of DSBs in somatic cells. We show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::825552fd1e987eb195830fc54ae0df7c
https://doi.org/10.1101/2022.08.24.505076