Výsledky vyhledávání

Akademický článek

In Vivo miRNA Decoy Screen Reveals miR-124a as a Suppressor of Melanoma Metastasis

Autor: Rana S. Moubarak, Lisa Koetz-Ploch, Gavriel Mullokandov, Avital Gaziel, Ana de Pablos-Aragoneses, Diana Argibay, Kevin Kleffman, Elena Sokolova, Marianne Berwick, Nancy E. Thomas, Iman Osman, Brian D. Brown, Eva Hernando

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Melanoma is a highly prevalent cancer with an increasing incidence worldwide and high metastatic potential. Brain metastasis is a major complication of the disease, as more than 50% of metastatic melanoma patients eventually develop intracranial dise

Externí odkaz: https://doaj.org/article/ea266918aeb143fab6f07c8c6b79e495

Zobrazit plný text záznamu

Akademický článek

The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation.

Autor: Daniel J Gough, Lisa Koetz, David E Levy

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e83395 (2013)

Activating mutations in the RasGTPases are the most common oncogenic lesions in human cancer. Similarly, elevated STAT3 expression and/or phosphorylation are observed in the majority of human cancers. We recently found that activated Ras requires a m

Externí odkaz: https://doaj.org/article/7f7fdc27a3cf4b9d9345a954871f8053

Zobrazit plný text záznamu

Akademický článek

Gli activity is critical at multiple stages of embryonic mammary and nipple development.

Autor: Anupama Chandramouli, Sarah J Hatsell, Alicia Pinderhughes, Lisa Koetz, Pamela Cowin

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79845 (2013)

Gli3 is a transcriptional regulator of Hedgehog (Hh) signaling that functions as a repressor (Gli3(R)) or activator (Gli3(A)) depending upon cellular context. Previously, we have shown that Gli3(R) is required for the formation of mammary placodes #3

Externí odkaz: https://doaj.org/article/5dd01fde7e064b38bc806d9473396989

Zobrazit plný text záznamu

Data from miR-204-5p and miR-211-5p Contribute to BRAF Inhibitor Resistance in Melanoma

Autor: Joaquin Teixidó, Eva Hernando, Lisa Koetz-Ploch, Lola Alonso, Lucía Benito-Jardón, Marta Díaz-Martínez

Melanoma treatment with the BRAF V600E inhibitor vemurafenib provides therapeutic benefits but the common emergence of drug resistance remains a challenge. We generated A375 melanoma cells resistant to vemurafenib with the goal of investigating chang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2344aa7b55a07fe0b5482d11807e590f
https://doi.org/10.1158/0008-5472.c.6510017

Zobrazit plný text záznamu

Data from A miRNA-Based Signature Detected in Primary Melanoma Tissue Predicts Development of Brain Metastasis

Autor: Eva Hernando, Iman Osman, Yongzhao Shao, Farbod Darvishian, Russell Berman, Richard Shapiro, Anna Pavlick, Shulian Shang, Daniel J. Lackaye, Avital Gaziel-Sovran, Lisa Koetz, Judy Zhong, Doug Hanniford

Purpose: Brain metastasis is the major cause of mortality among patients with melanoma. A molecular prognostic test that can reliably stratify patients at initial melanoma diagnosis by risk of developing brain metastasis may inform the clinical manag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7b559f37e2892ef1b8d9c22906ae21
https://doi.org/10.1158/1078-0432.c.6523844

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání