Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Lisa Kinch"'
Autor:
Niranjan Venkateswaran, Roy Garcia, M. Carmen Lafita-Navarro, Yi-Heng Hao, Lizbeth Perez-Castro, Pedro A. S. Nogueira, Ashley Solmonson, Ilgen Mender, Jessica A. Kilgore, Shun Fang, Isabella N. Brown, Li Li, Emily Parks, Igor Lopes dos Santos, Mahima Bhaskar, Jiwoong Kim, Yuemeng Jia, Andrew Lemoff, Nick V. Grishin, Lisa Kinch, Lin Xu, Noelle S. Williams, Jerry W. Shay, Ralph J. DeBerardinis, Hao Zhu, Maralice Conacci-Sorrell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cancer cells exhibit distinct metabolic activities and nutritional dependencies compared to normal cells. Thus, characterization of nutrient demands by individual tumor types may identify specific vulnerabilities that can be manipulated to t
Externí odkaz:
https://doaj.org/article/6ee60b31df8e443cb81fea064aabbe4b
Autor:
Jetsy Montero-Vergara, Kira Plachetta, Lisa Kinch, Stephan Bernhardt, Kriti Kashyap, Beth Levine, Lipi Thukral, Martina Vetter, Christoph Thomssen, Stefan Wiemann, Samuel Peña-Llopis, Verena Jendrossek, Silvia Vega-Rubin-de-Celis
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract GRB2 is an adaptor protein of HER2 (and several other tyrosine kinases), which we identified as a novel BECN1 (Beclin 1) interacting partner. GRB2 co-immunoprecipitated with BECN1 in several breast cancer cell lines and regulates autophagy t
Externí odkaz:
https://doaj.org/article/762fefe82a1e46f087b2a5cf64ad3261
Autor:
M. Carmen Lafita-Navarro, Yi-Heng Hao, Chunhui Jiang, Seoyeon Jang, Tsung-Cheng Chang, Isabella N. Brown, Niranjan Venkateswaran, Elizabeth Maurais, Weronika Stachera, Yanfeng Zhang, Dorothy Mundy, Jungsoo Han, Vanna M. Tran, Marcel Mettlen, Lin Xu, Jeffrey B. Woodruff, Nick V. Grishin, Lisa Kinch, Joshua T. Mendell, Michael Buszczak, Maralice Conacci-Sorrell
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113280- (2023)
Summary: Increased nucleolar size and activity correlate with aberrant ribosome biogenesis and enhanced translation in cancer cells. One of the first and rate-limiting steps in translation is the interaction of the 40S small ribosome subunit with mRN
Externí odkaz:
https://doaj.org/article/c9443ad8099941449a8b52f34efe5875
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 312 (2022)
Identified over twenty years ago and distantly related to animal caspases are a group of cysteine proteases known as metacaspases. Throughout the years, much like caspase roles in metazoans, metacaspases have been shown to be involved in regulating c
Externí odkaz:
https://doaj.org/article/6499551707ce475790e8d6662d37be3e
Autor:
Jessie Fernandez, Victor Lopez, Lisa Kinch, Mariel A. Pfeifer, Hillery Gray, Nalleli Garcia, Nick V. Grishin, Chang-Hyun Khang, Kim Orth
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Magnaporthe oryzaeM. oryzae
Externí odkaz:
https://doaj.org/article/e6b13ac4ca6648cf837a0f08f72e2cd2
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract The manual classification of protein domains is approaching its 20th anniversary. ECOD is our mixed manual-automatic domain classification. Over time, the types of proteins which require manual curation has changed. Depositions with complex
Externí odkaz:
https://doaj.org/article/19c77f981dcd49a098355749d769b373
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9210 (2020)
Beclin 1 is a major regulator of autophagy, and it is a core component of the class III PI3K complexes. Beclin 1 is a highly conserved protein and its function is regulated in a number of ways, including post-translational modifications. Several stud
Externí odkaz:
https://doaj.org/article/d877e82453564a09a2c8cd3b37d24ecf
Autor:
Oleg A Volkov, Lisa Kinch, Carson Ariagno, Xiaoyi Deng, Shihua Zhong, Nick Grishin, Diana R Tomchick, Zhe Chen, Margaret A Phillips
Publikováno v:
eLife, Vol 5 (2016)
Catalytically inactive enzyme paralogs occur in many genomes. Some regulate their active counterparts but the structural principles of this regulation remain largely unknown. We report X-ray structures of Trypanosoma brucei S-adenosylmethionine decar
Externí odkaz:
https://doaj.org/article/8fb0a907483d4638b5df7535ddd67675
Autor:
Sergey Ovchinnikov, Lisa Kinch, Hahnbeom Park, Yuxing Liao, Jimin Pei, David E Kim, Hetunandan Kamisetty, Nick V Grishin, David Baker
Publikováno v:
eLife, Vol 4 (2015)
The prediction of the structures of proteins without detectable sequence similarity to any protein of known structure remains an outstanding scientific challenge. Here we report significant progress in this area. We first describe de novo blind struc
Externí odkaz:
https://doaj.org/article/bf36d51e866a428788292677ef37e206
Autor:
James Brugarolas, W. Marston Linehan, Charis Eng, Patricia L.M. Dahia, Xian-Jin Xie, Chao Xing, Adam R. Metwalli, Maria J. Merino, Nick Grishin, Lisa Kinch, Lindsay Middelton, James Peterson, Christopher J. Ricketts, Cathy D. Vocke, Alana Christie, Andrea Pavia-Jimenez, Samuel Peña-Llopis, Jessica L. Mester, Laura S. Schmidt, Megan N. Farley
PDF file - 233K, VHL mutation status in some but not all tumors from Family NCI-1326.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1a107592d76de15555689e3e2f1575
https://doi.org/10.1158/1541-7786.22509765
https://doi.org/10.1158/1541-7786.22509765