Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lisa Kays"'
Autor:
Timothy P. Burkholder, Sandaruwan Geeganage, Ming-Shang Kuo, Sean Buchanan, Ken D. Roth, Maria-Carmen Fernandez, James R. Gillig, Miriam Del Prado, Shobha Bhattachar, Wenjuan Wu, Robert L. Johnson, Lisa Kays, Xueqian Gong, Bo Tan, Tao Wang, Sucai Dong, Robert Shepard, Lourdes Prieto, Yu-Hua Hui, Colin F. Green, Genshi Zhao
The concentrations of LSN3154567 in the dog plasma samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e6822518f21d94bca7c1d9980cb9dc
https://doi.org/10.1158/1535-7163.22510030.v1
https://doi.org/10.1158/1535-7163.22510030.v1
Autor:
Timothy P. Burkholder, Sandaruwan Geeganage, Ming-Shang Kuo, Sean Buchanan, Ken D. Roth, Maria-Carmen Fernandez, James R. Gillig, Miriam Del Prado, Shobha Bhattachar, Wenjuan Wu, Robert L. Johnson, Lisa Kays, Xueqian Gong, Bo Tan, Tao Wang, Sucai Dong, Robert Shepard, Lourdes Prieto, Yu-Hua Hui, Colin F. Green, Genshi Zhao
NAMPT, an enzyme essential for NAD+ biosynthesis, has been extensively studied as an anticancer target for developing potential novel therapeutics. Several NAMPT inhibitors have been discovered, some of which have been subjected to clinical investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aee608d35f9d18aa0d631046f9435f6
https://doi.org/10.1158/1535-7163.c.6539479
https://doi.org/10.1158/1535-7163.c.6539479
Autor:
Timothy P. Burkholder, Sandaruwan Geeganage, Ming-Shang Kuo, Sean Buchanan, Ken D. Roth, Maria-Carmen Fernandez, James R. Gillig, Miriam Del Prado, Shobha Bhattachar, Wenjuan Wu, Robert L. Johnson, Lisa Kays, Xueqian Gong, Bo Tan, Tao Wang, Sucai Dong, Robert Shepard, Lourdes Prieto, Yu-Hua Hui, Colin F. Green, Genshi Zhao
Table S1: anti-proliferative activity of LSN3154567 against different cancer cell lines; Table S2: effects of NAM on the anti-proliferative activity of LSN3154567
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f70612a84c12c12c5e1209c6248e3b6
https://doi.org/10.1158/1535-7163.22510024
https://doi.org/10.1158/1535-7163.22510024
Autor:
Burkholder Timothy P, Maria-Carmen Fernandez, Gillig James Ronald, Lourdes Prieto, Miriam del Prado, Bo Tan, Genshi Zhao, Tao Wang, Robert L. Johnson, Yu-Hua Hui, Ken D. Roth, Shobha N. Bhattachar, Sean Buchanan, Xueqian Gong, Sandaruwan Geeganage, Robert L. Shepard, Ming-Shang Kuo, Colin F. Green, Lisa Kays, Wenjuan Wu, Sucai Dong
Publikováno v:
Molecular Cancer Therapeutics. 16:2677-2688
NAMPT, an enzyme essential for NAD+ biosynthesis, has been extensively studied as an anticancer target for developing potential novel therapeutics. Several NAMPT inhibitors have been discovered, some of which have been subjected to clinical investiga
Autor:
Steven M. Chan, Mary Sabatier, Vivian Salama, Anna Skwarska, Lisa Kays, Sandaruwan Geeganage, Raymond Gilmour, Nathan A. Brooks, Marina Konopleva, Katherine Newell, Paul L. Milligan, Jean-Emmanuel Sarry, Kenneth D. Roth, Courtney D. DiNardo
Publikováno v:
Cancer Research. 80:6417-6417
Acute myeloid leukemia is associated with the abnormal proliferation of myeloid progenitor cells unable to differentiate. Somatic gain-of-function mutations in isocitrate dehydrogenase (IDH) 1 occur in 10% of newly diagnosed AML patients. IDH1 mutati
Autor:
Bryan D. Smith, Xiwen Ma, Ilaria Conti, Daniel L. Flynn, Yue Webster, Subha Vogeti, Xiaoyi Zhang, Lisa Kays, Robert D. Van Horn, Phenil J. Patel, Youyan Zhang, Gregory P. Donoho, Shih-Hsun Chen, Sean Buchanan, Lawrence Chun, Lysiane Huber, Thomas J. Rutkoski, Tinggui Yin, Vipin Yadav, Denis J. McCann, Igor Mochalkin, Gregory D. Plowman, Henry James Robert, James J. Starling, Jennie L. Walgren, Sheng-Bin Peng, Wei-Ping Lu, Michael Kaufman, Xueqian Gong, Scott C. Wise
Publikováno v:
Cancer Cell. 28:384-398
SummaryLY3009120 is a pan-RAF and RAF dimer inhibitor that inhibits all RAF isoforms and occupies both protomers in RAF dimers. Biochemical and cellular analyses revealed that LY3009120 inhibits ARAF, BRAF, and CRAF isoforms with similar affinity, wh
Publikováno v:
Social Work in Health Care. 53:900-919
The world that social work exists in is no longer defined by traditional physical settings and boundaries, such as schools, agencies, or even offices. With the advent of the Internet and digital communications, social work now exists in a far more co
Autor:
Kenneth D. Roth, Denis J. McCann, Renato A. Bauer, John Strelow, Ramon V. Tiu, Patric James Hahn, Gary Mo, Zoran Rankovic, Sandaruwan Geeganage, Lisa Kays, Raymond Gilmour, Nathan A. Brooks, Paul L. Milligan, ZhaoHai Lu, Sandra Gomez, Robin DeWalt, Stephen Antonysamy, Rachel N. Cavitt, Serge Louis Boulet, Burkholder Timothy P
Publikováno v:
Cancer Research. 79:LB-274
Somatic gain-of-function mutations in IDH1 have been identified in multiple tumor types including AML, glioma, cholangiocarcinoma and chondrosarcoma. The neo-enzymatic activity of mutant IDH1 results in accumulation of the oncometabolite 2-hydroxyglu
Autor:
Julie Stewart, Ming Ye, Peter Edward Vaillancourt, Lisa Kays, Donald C. Paul, Sheng-Bin Peng, Mark Uhlik, Michele Dowless, Haiyan Long, Victor H. Obungu, Shaoyou Chu, Louis Stancato, Xiaoyi Zhang
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 3, p e0150585 (2016)
PLoS ONE, Vol 11, Iss 3, p e0150585 (2016)
SDF-1 and CXCR4 are a chemokine and chemokine receptor pair playing critical roles in tumorigenesis. Overexpression of CXCR4 is a hallmark of many hematological malignancies including acute myeloid leukemia, chronic lymphocytic leukemia and non-Hodgk
Autor:
Bryan D. Smith, Sheng-Bin Peng, Wei-Ping Lu, Clay Julia Marie, Jeffrey Daniel Cohen, Phenil J. Patel, C. Groshong, Molly M. Hood, Lakshminarayana Vogeti, David Miller, Youyan Zhang, Michael Kaufman, Subha Vogeti, Philip Arthur Hipskind, Wrobleski Aaron D, Xiaoyi Zhang, Yu Mi Ahn, Lisa Kays, Scott C. Wise, Henry James Robert, Danalyn Manglicmot, Timothy M. Caldwell, Sherry Guo, Daniel L. Flynn, Denis J. McCann, Karen Lynn Lobb, David K. Clawson, Cheyenne Logan, Lawrence Chun, Hanumaiah Telikepalli, Jennie L. Walgren, James J. Starling, Thomas J. Rutkoski
Publikováno v:
Journal of medicinal chemistry. 58(10)
The RAS-RAF-MEK-MAPK cascade is an essential signaling pathway, with activation typically mediated through cell surface receptors. The kinase inhibitors vemurafenib and dabrafenib, which target oncogenic BRAF V600E, have shown significant clinical ef