Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lisa Kashima"'
Autor:
Iwao Ohkubo, Hisakazu Ogita, Takuya Yamane, Motoki Yuguchi, Miyuki Kozuka, Izumi Kato-Ose, Keisuke Takeuchi, Lisa Kashima, Hiroyoshi Ariga, Sato Murao
Publikováno v:
Biochemical and Biophysical Research Communications. 438:613-618
Legumain (EC 3.4.22.34) is an asparaginyl endopeptidase. Strong legumain activity was observed in the mouse kidney, and legumain was found to be highly expressed in tumors. We previously reported that bovine kidney annexin A2 was co-purified with leg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd80edb5253bdc6eedcbed3bd8fb910
https://doi.org/10.1016/j.bbrc.2013.08.007
https://doi.org/10.1016/j.bbrc.2013.08.007
Autor:
Miyuki Tamura, Lisa Kashima, Yasuhisa Shinomura, Toshiharu Yamashita, Kohzoh Imai, Yasushi Sasaki, Masashi Idogawa, Yuichiro Oshima, M Toyota, Ryota Koyama, Takashi Tokino
Publikováno v:
Cancer Gene Therapy. 19:749-756
The p53 tumor suppressor belongs to a gene family that includes two other structurally and functionally related members: p73 and p63. The regulation of p53 activity differs significantly from that of p73 and p63. To enhance the tumor suppressive acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c704e6497d74c649bd8cdef06740dd7
https://doi.org/10.1038/cgt.2012.51
https://doi.org/10.1038/cgt.2012.51
Autor:
Minoru Toyota, Kazuhiro Ogi, Hiroaki Mita, Yasushi Sasaki, Masashi Idogawa, Takashi Tokino, Tesshi Yamada, Hiroyoshi Ariga, Miki Shitashige, Hiromu Suzuki, Lisa Kashima
Publikováno v:
Journal of Biological Chemistry. 287:12975-12984
The mitotic checkpoint gene CHFR (checkpoint with forkhead-associated (FHA) and RING finger domains) is silenced by promoter hypermethylation or mutated in various human cancers, suggesting that CHFR is an important tumor suppressor. Recent studies h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d7041df0edac8eefea4d1d7f70c0ac
https://doi.org/10.1074/jbc.m111.321828
https://doi.org/10.1074/jbc.m111.321828
Autor:
Daniel Chua, Josephine Mun Yee Ko, Kwok Wah Chan, Eric J. Stanbridge, Arthur Kwok Leung Cheung, Hong Lok Lung, Maria Li Lung, Dora L.W. Kwong, Eugene R. Zabarovsky, Sai Wah Tsao, Lisa Kashima, Toshiharu Suzuki, Takashi Tokino
Publikováno v:
Proceedings of the National Academy of Sciences. 108:8390-8395
Chromosome 14 was transferred into tumorigenic nasopharyngeal carcinoma and esophageal carcinoma cell lines by a microcell-mediated chromosome transfer approach. Functional complementation of defects present in the cancer cells suppressed tumor forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ae8892994bd9cde179de170f1dd599
https://doi.org/10.1073/pnas.1101747108
https://doi.org/10.1073/pnas.1101747108
Publikováno v:
Tumor Research. 45:33-44
Since the 1980s cancer is the leading cause of death in Japan. Most human cancers exhibit inactivation of the p53 network, either through direct mutation of p53,or through disruption of regulatory pathways essential for p53 function.The tumor suppres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::c1353560ce4dd5947dde9e721c86818f
https://sapmed.repo.nii.ac.jp/records/14152
https://sapmed.repo.nii.ac.jp/records/14152
Autor:
Lisa Kashima, M Toyota, Yasushi Sasaki, Takashi Tokino, Hiroaki Mita, Masashi Idogawa, Hiromu Suzuki, Kazuhiro Ogi
Publikováno v:
Oncogene. 28:2643-2653
The mitotic checkpoint gene CHFR (checkpoint with forkhead and ring finger domains) is silenced in various human cancers by promoter hypermethylation, suggesting that CHFR is a tumor suppressor. Here, we show that CHFR functions as a negative regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2faba5a4bb5429e2c557f5ccb77d6020
https://doi.org/10.1038/onc.2009.123
https://doi.org/10.1038/onc.2009.123
Autor:
Takashi Tokino, Masashi Idogawa, Tomoko Ohashi, Hiromu Suzuki, Lisa Kashima, Yasushi Sasaki, Reo Maruyama
Publikováno v:
Human molecular genetics. 23(11)
p53 is one of the most important known tumor suppressor genes, and it is inactivated in approximately half of human cancers. p53 family members execute various functions, such as apoptosis induction and cell cycle arrest, by modulating transcriptiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18bfecd70c75ab05f79440132c8b915
https://pubmed.ncbi.nlm.nih.gov/24403050
https://pubmed.ncbi.nlm.nih.gov/24403050
Publikováno v:
International journal of oncology. 37(6)
Tumor suppressor p53 is a transcription factor that induces growth arrest and/or apoptosis in response to cellular stress. In recent years, many genes have been identified as p53-regulated genes; however, no single target gene has been shown to be re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9934aadc259e466fc5c1482d22aded1
https://pubmed.ncbi.nlm.nih.gov/21042708
https://pubmed.ncbi.nlm.nih.gov/21042708
Publikováno v:
Checkpoint Responses in Cancer Therapy ISBN: 9781588299307
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26ef5eaaa06bf49954949dba9d78415d
https://doi.org/10.1007/978-1-59745-274-8_7
https://doi.org/10.1007/978-1-59745-274-8_7
Autor:
Hiroaki Mita, Kazuhiro Ogi, Kimishige Akino, Fumio Itoh, Yasuhisa Shinomura, Hiromu Suzuki, Hiroyoshi Hiratsuka, Reo Maruyama, Lisa Kashima, Takashi Imai, Masanori Nojima, Yohei Sogabe, Yasushi Sasaki, Minoru Toyota, Kohzoh Imai, Takashi Tokino
Publikováno v:
Cancer science. 99(5)
Genetic and epigenetic alterations in tumor-suppressor genes play important roles in human neoplasia. Ras signaling is often activated in oral squamous cell carcinoma (OSCC), although Ras mutations are rarely detected in Japanese OSCC patients, and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8b4bd1f5f882212ac255958a102603
https://pubmed.ncbi.nlm.nih.gov/18294275
https://pubmed.ncbi.nlm.nih.gov/18294275