Normalization of Fetal Cerebral and Hepatic Iron by Parental Iron Therapy to Pregnant Rats with Systemic Iron Deficiency without Anemia

Autor: Annette Burkhart, Kasper Bendix Johnsen, Tina Skjørringe, Asbjørn Haaning Nielsen, Lisa Juul Routhe, Sandra Hertz, Lisbeth Birk Møller, Lars Lykke Thomsen, Torben Moos

Publikováno v: Nutrients, Vol 16, Iss 19, p 3264 (2024)

Background/Objectives: Iron (Fe) is a co-factor for enzymes of the developing brain necessitating sufficient supply. We investigated the effects of administering ferric derisomaltose/Fe isomaltoside (FDI) subcutaneously to Fe-deficient (ID) pregnant

Externí odkaz: https://doaj.org/article/1cda8fe63fb84217834ad2855138a162

A novel strategy for delivering N iemann‐ P ick type C2 proteins across the blood–brain barrier using the brain endothelial‐specific AAV‐BR1 virus

Autor: Charlotte Laurfelt Munch Rasmussen, Eva Hede, Lisa Juul Routhe, Jakob Körbelin, Steinunn Sara Helgudottir, Louiza Bohn Thomsen, Markus Schwaninger, Annette Burkhart, Torben Moos

Publikováno v: Journal of Neurochemistry. 164:6-28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c1be5138d8139a7d3413f7ea7f08242
https://doi.org/10.1111/jnc.15621

Epigenetic upregulation by valproic acid of transferrin receptor 1, and not glucose transporter 1 or CD98hc, at the blood-brain barrier

Autor: Steinunn Sara Helgudóttir, Kasper Bendix Johnsen, Lisa Juul Routhe, Charlotte L.M. Rasmussen, Azra Karamehmedovic, Maj Schneider Thomsen, Torben Moos

BackgroundThe objectives of the present study were to investigate whether the expression of transferrin receptor 1 (TfR1), glucose transporter 1 (Glut1), or Cluster of Differentiation 98 Heavy Chain (CD98hc) is epigenetically regulated in brain capil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce493df1c2a6de1602fb6d71ad190e26
https://doi.org/10.21203/rs.3.rs-1220062/v1

Blood-brain barrier pathology in patients with severe mental disorders:a systematic review and meta-analysis of biomarkers in case-control studies

Autor: Jesper Krogh, Rebecca Margolinsky, Torben Moos, Jørgen Rungby, Michael E. Benros, Jesper Futtrup, Lisa Juul Routhe

Publikováno v: Futtrup, J, Margolinsky, R, Benros, M E, Moos, T, Routhe, L J, Rungby, J & Krogh, J 2020, ' Blood-brain barrier pathology in patients with severe mental disorders : a systematic review and meta-analysis of biomarkers in case-control studies ', Brain, behavior, & immunity-health, vol. 6, 100102 . https://doi.org/10.1016/j.bbih.2020.100102
Futtrup, J, Margolinsky, R, Benros, M E, Moos, T, Routhe, L J, Rungby, J & Krogh, J 2020, ' Blood-brain barrier pathology in patients with severe mental disorders : a systematic review and meta-analysis of biomarkers in case-control studies ', Brain, Behavior, and Immunity-Health, vol. 6, 100102 . https://doi.org/10.1016/j.bbih.2020.100102
Brain, Behavior, & Immunity-Health
Brain, Behavior, & Immunity-Health, Vol 6, Iss, Pp 100102-(2020)

Background Blood-brain barrier (BBB) pathology may be associated with mental disorders. The aim of this systematic review and meta-analysis is to identify, evaluate and summarize available evidence on whether potential biomarkers of BBB pathology are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2359fe33d149d888c34718e908eea481
https://curis.ku.dk/ws/files/283211637/Blood_brain_barrier_pathology_in_patients_with_severe_mental_disorders.pdf

Astrocytic expression of ZIP14 (SLC39A14) is part of the inflammatory reaction in chronic neurodegeneration with iron overload

Autor: Lissa V. Hauerslev, Issa I. Issa, Lisa Juul Routhe, Maj Schneider Thomsen, Ida K. Andersen, Torben Moos

Publikováno v: Routhe, L J, Andersen, I K, Hauerslev, L V, Issa, I I, Moos, T & Thomsen, M S 2020, ' Astrocytic expression of ZIP14 (SLC39A14) is part of the inflammatory reaction in chronic neurodegeneration with iron overload ', Glia, vol. 68, no. 9, pp. 1810-1823 . https://doi.org/10.1002/glia.23806

Neurodegeneration is associated with inflammation and mismanaged iron homeostasis, leading to increased concentration of non-transferrin-bound iron (NTBI) in the brain. NTBI can be taken up by cells expressing Zrt-, Irt-like protein-14 (ZIP14), which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3185d4b13f61be32c937278f5c174c4
https://pubmed.ncbi.nlm.nih.gov/32077535