Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lisa J. Pagliari"'
Publikováno v:
Current Molecular Medicine. 1:597-608
The regulation of proliferation and cell death is vital for homeostasis, but the mechanisms that coordinately balances these two events in rheumatoid arthritis (RA) remains largely unknown. In RA, the synovial lining increases through enhanced prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5a0cfe4db84859c3ab9eef490cff22
https://doi.org/10.2174/1566524013363429
https://doi.org/10.2174/1566524013363429
Autor:
Richard M. Pope, Lisa J. Pagliari, Kathleen Bradley, Hongtao Liu, Nadine Nguyen, Harris Perlman
Publikováno v:
European Journal of Immunology. 31:2421-2430
Peripheral blood-derived monocytes spontaneously undergo apoptosis mediated by Fas-Fas ligand (FasL) interactions. Activation of monocytes by LPS or TNF-alpha prevents spontaneous monocyte apoptosis through an unknown mechanism. Here, we demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43efc4184782b84bdbecbf22101d1fd3
https://doi.org/10.1002/1521-4141(200108)31:8<2421::aid-immu2421>3.0.co
https://doi.org/10.1002/1521-4141(200108)31:8<2421::aid-immu2421>3.0.co
Publikováno v:
Journal of Experimental Medicine. 194:113-126
Recent data from mice deficient for phosphatase and tensin homologue deleted from chromosome 10 or src homology 2 domain–containing 5′ inositol phosphatase, phosphatases that negatively regulate the phosphatidylinositol 3-kinase (PI3K) pathway, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88d74acd42c72fe4bebd51b6f277bc93
https://doi.org/10.1084/jem.194.2.113
https://doi.org/10.1084/jem.194.2.113
Autor:
G. Kenneth Haines, Alisa E. Koch, Lisa J. Pagliari, Hongtao Liu, Harris Perlman, Richard M. Pope
Publikováno v:
Arthritis & Rheumatism. 44:21-30
Objective The chronic inflammation and progressive joint destruction observed in rheumatoid arthritis (RA) are mediated in part by macrophages. A paucity of apoptosis has been observed in RA synovial tissues, yet the mechanism remains unknown. The pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32640afcaff0ff2bf6b6ece6d43f9d65
https://doi.org/10.1002/1529-0131(200101)44:1<21::aid-anr4>3.0.co
https://doi.org/10.1002/1529-0131(200101)44:1<21::aid-anr4>3.0.co
Publikováno v:
Molecular and Cellular Biology. 20:8855-8865
NF-kappaB is a critical mediator of macrophage inflammatory responses, but its role in regulating macrophage survival has yet to be elucidated. Here, we demonstrate that constitutive NF-kappaB activation is essential for macrophage survival. Blocking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082964385546e50726276a5e5816f6b1
https://doi.org/10.1128/mcb.20.23.8855-8865.2000
https://doi.org/10.1128/mcb.20.23.8855-8865.2000
Autor:
Alisa E. Koch, Richard M. Pope, Constantinos Georganas, Lisa J. Pagliari, Kenneth Haines, Harris Perlman
Publikováno v:
The Journal of Immunology. 164:5227-5235
The regulation of proliferation and cell death is vital for homeostasis, but the mechanism that coordinately balances these events in rheumatoid arthritis (RA) remains largely unknown. In RA, the synovial lining thickens in part through increased pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8d10ba3c4bf7cb22c8a0d497cb85fa
https://doi.org/10.4049/jimmunol.164.10.5227
https://doi.org/10.4049/jimmunol.164.10.5227
Autor:
Constantinos Georganas, Richard M. Pope, Lisa J. Pagliari, Kenneth Walsh, Harris Perlman, Toshiaki Mano
Publikováno v:
The Journal of Experimental Medicine
Macrophages differentiated from circulating peripheral blood monocytes are essential for host immune responses and have been implicated in the pathogenesis of rheumatoid arthritis and atherosclerosis. In contrast to monocytes, macrophages are resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e022fef6feda09be2c916f821cfa4fea
https://doi.org/10.1084/jem.190.11.1679
https://doi.org/10.1084/jem.190.11.1679
Autor:
Tri M. Tran, Bo Shi, Soizic Daniel, Richard M. Pope, Vladislav Temkin, Lisa J. Pagliari, Christiane Ferran
Publikováno v:
Apoptosis : an international journal on programmed cell death. 14(3)
Macrophages are the principal source of TNFalpha, yet they are highly resistant to TNFalpha-mediated cell death. Previously, employing in vitro differentiated human macrophages, we showed that following the inhibition of NF-kappaB, TNFalpha-induced c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50cbe30aa7397c3143e1fa8af434d80
https://pubmed.ncbi.nlm.nih.gov/19152111
https://pubmed.ncbi.nlm.nih.gov/19152111
Autor:
Lisa Bouchier-Hayes, Christine Bonzon, Donald D. Newmeyer, Douglas R. Green, Lisa J. Pagliari
Publikováno v:
Molecular biology of the cell. 17(5)
The mechanisms through which Caspase-2 leads to cell death are controversial. Here we show, using a combination of cell-free and cell culture-based approaches, that cleavage of the Bcl-2-family protein Bid is required for the induction of apoptosis b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b33602ff288af332bf6f414e31e3430
https://pubmed.ncbi.nlm.nih.gov/16495337
https://pubmed.ncbi.nlm.nih.gov/16495337
Autor:
Douglas R. Green, Christine Bonzon, Tomomi Kuwana, Donald D. Newmeyer, Helen M. Beere, Lisa J. Pagliari, S. Sean Tu
During apoptosis, engagement of the mitochondrial pathway involves a decisive event characterized by the release of mitochondrial intermembrane space proteins, such as cytochrome c . This permeabilization of the mitochondrial outer membrane depends o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476a7705f5ebce22ccc42dd7282e2602
https://europepmc.org/articles/PMC1312392/
https://europepmc.org/articles/PMC1312392/
