Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lisa J. Lojek"'
Autor:
Samantha J. Nelson, John T. Williams, John A. Buglino, Subhalaxmi Nambi, Lisa J. Lojek, Michael S. Glickman, Thomas R. Ioerger, Christopher M. Sassetti
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT Mycobacterium tuberculosis is exposed to a variety of stresses during a chronic infection, as the immune system simultaneously produces bactericidal compounds and starves the pathogen of essential nutrients. The intramembrane protease, Rip1,
Externí odkaz:
https://doaj.org/article/3ff0ef3e4c504a0da4ca3f3ee42264fd
Autor:
Lisa J. Lojek, Allison J. Farrand, Jennifer H. Wisecaver, Crysten E. Blaby-Haas, Brian W. Michel, Sabeeha S. Merchant, Antonis Rokas, Eric P. Skaar
Publikováno v:
mSphere, Vol 2, Iss 4 (2017)
ABSTRACT Heme is essential for respiration across all domains of life. However, heme accumulation can lead to toxicity if cells are unable to either degrade or export heme or its toxic by-products. Under aerobic conditions, heme degradation is perfor
Externí odkaz:
https://doaj.org/article/e779373f48724f7fbad545b38962453b
Publikováno v:
International Journal of Medical Microbiology. 308:582-589
Heme is a cofactor that is essential for cellular respiration and for the function of many enzymes. If heme levels become too low within the cell, S. aureus switches from producing energy via respiration to producing energy by fermentation. S. aureus
Autor:
Jocelyn Simpson, Audra R. Fullen, Matthew E. Albertolle, Lisa J. Lojek, Gary A. Sulikowski, Kenneth J. Salleng, E. Duco Jansen, R. Nagarajan, Matthew C. Surdel, Brendan F. Dutter, Pedro L. Teixeira, Harry A. Dailey, Eric P. Skaar, Jeremy B. Ford, J. Logan Jenkins, Dennis J. Horvath, D. Borden Lacy, Ivelin S. Georgiev
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Significance Skin and soft tissue infections (SSTIs) account for a majority of visits to hospitals and clinics in the United States and are typically caused by Gram-positive pathogens. Recently, it was discovered that Gram-positive bacteria use a uni
Autor:
Neal D. Hammer, C. Buddy Creech, James E. Cassat, Eric P. Skaar, Lisa J. Lojek, Ashley D. Chadha, Michael J. Noto, Jonathan E. Schmitz
Publikováno v:
Cell Host & Microbe. 16:531-537
Summary Adaptations that enable antimicrobial resistance often pose a fitness cost to the microorganism. Resistant pathogens must therefore overcome such fitness decreases to persist within their hosts. Here we demonstrate that the reduced fitness as