Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lisa Hooi"'
Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
Autor:
Martin L. Decaris, Johanna R. Schaub, Chun Chen, Jacob Cha, Gail G. Lee, Megi Rexhepaj, Steve S. Ho, Vikram Rao, Megan M. Marlow, Prerna Kotak, Erine H. Budi, Lisa Hooi, Jianfeng Wu, Marina Fridlib, Shamra P. Martin, Shaoyi Huang, Ming Chen, Manuel Muñoz, Timothy F. Hom, Paul J. Wolters, Tushar J. Desai, Fernando Rock, Katerina Leftheris, David J. Morgans, Eve-Irene Lepist, Patrick Andre, Eric A. Lefebvre, Scott M. Turner
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs. Obj
Externí odkaz:
https://doaj.org/article/f75a5266ef724db48db905d69406f78e
Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
Autor:
Patrick Andre, Martin Decaris, Chun Chen, Munoz Manuel, Hom Timothy, Scott M. Turner, Ming Chen, Tushar J. Desai, Megan M. Marlow, Cha Jacob, Eric Lefebvre, Steve S. Ho, Paul J. Wolters, Shaoyi Huang, Eve-Irene Lepist, Katerina Leftheris, David J Morgans, Lisa Hooi, Johanna R. Schaub, Vikram R. Rao, Jianfeng Wu, Marina Fridlib, Fernando Rock, Megi Rexhepaj, Erine H. Budi, Prerna Kotak, Gail Lee, Shamra Martin
Publikováno v:
Respiratory research, vol 22, iss 1
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)
Rationale αv integrins, key regulators of transforming growth factor-β activation and fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial cells (αvβ6) and fibroblasts (αvβ1) in fibrotic lungs. Objectives W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8943da51a8a3553a1e3711bc9a9ed07
https://escholarship.org/uc/item/5q12m0vq
https://escholarship.org/uc/item/5q12m0vq
Autor:
Eric Lefebvre, Maureen Reilly, Chun Chen, Katerina Leftheris, Vikram R. Rao, Lisa Hooi, Jianfeng Wu, Eduard Gorina, Scott Turner, Gail Lee, Jake Cha, Tony Chen, Johanna R. Schaub, Martin Decaris, Prerna Kotak, Munoz Manuel, Patrick Andre, Hom Timothy, Shamra Martin, Megi Rexhepaj, Cooper Nicole
Publikováno v:
Idiopathic interstitial pneumonias.
Integrin αVβ6 (epithelial cell) and αVβ1 (fibroblast)-mediated activation of TGF-β have been shown to promote fibrosis in the bleomycin lung injury model, and elevated levels of αVβ6 have been found in human IPF lung tissue. Through the develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38c605362d65a6584058ceae0e0ba3df
https://doi.org/10.1183/13993003.congress-2019.pa1286
https://doi.org/10.1183/13993003.congress-2019.pa1286
Autor:
Patrick Andre, Vickram Rao, Martin Decaris, Irene Lepist, Lisa Hooi, Meghi Rexhepaj, Gail Lee, Shamra Martin, Perna Kotak, Katarina Leftheris, Maureen Reilly, Chun Chen, Johanna R. Schaub, Jake Cha, Scott Turner
Publikováno v:
Journal of Hepatology. 70:e57-e58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5feefd54b1cda31ab12571881c0f192
https://doi.org/10.1016/s0618-8278(19)30103-3
https://doi.org/10.1016/s0618-8278(19)30103-3
Autor:
Scott D. Seiwert, Karl Kossen, John B. Nicholas, Jyanwei Liu, Caralee Schaefer, Brad O. Buckman, Lea Huang, Donald Ruhrmund, Sharlene Lim, Lisa Hooi, Leonid Beigelman, Lin Pan, Vladimir Serebryany, Sarah K. Stevens, Srikonda Sastry, Shawn Misialek, Sophia Yap, Ravi Rajagopalan, Natalia Aleskovski
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
The current paradigm for the treatment of chronic hepatitis C virus (HCV) infection involves combinations of agents that act directly on steps of the HCV life cycle. Here we report the preclinical characteristics of ITMN-8187, a nonmacrocyclic inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e526d623aa25a82e039d51bfe79da1d8
https://doi.org/10.1128/aac.01569-16
https://doi.org/10.1128/aac.01569-16
Autor:
Jin Hong, John B. Nicholas, Sharlene R. Lim, Eva Herrmann, Karl Kossen, Scott D. Seiwert, Xiaoli Qin, Patrick F. Smith, Bradford Williamson Ziegler, Christophe Sarrazin, Stefan Zeuzem, Isabel Najera, Ann Arfsten, Simone Susser, Christian M. Lange, Lisa Hooi
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:271-279
Danoprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor that promotes multi-log 10 reductions in HCV RNA when administered as a 14-day monotherapy to patients with genotype 1 chronic HCV. Of these patients, 14/37 experienced a continuous de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b758ae33446d5e8fbf6755d5a4d60c
https://doi.org/10.1128/aac.05636-11
https://doi.org/10.1128/aac.05636-11
Autor:
Antitsa Dimitrova Stoycheva, Leonid Beigelman, Karl Kossen, P. T. Ravi Rajagopalan, Donald Ruhrmund, Guangyi Wang, Brunella Felicetti, Colin H. MacKinnon, Scott D. Seiwert, Christian A.G.N. Montalbetti, Brad O. Buckman, Debasis Das, Dorian Leo Schönfeld, Huoxing Lei, Thomas Stephen Coulter, John Barker, Jian Hong, Shawn Misialek, Lisa Hooi, Sarah E. Bailey, Xinjie Gai, Wang Xiaofang, Robert K. Y. Cheng, Richard John Mears
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4480-4483
(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives have been investigated as potential anti-HCV drugs. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000ef0a9262fe818849b255d0368b7bd
https://doi.org/10.1016/j.bmcl.2009.05.022
https://doi.org/10.1016/j.bmcl.2009.05.022
Autor:
Shawn Misialek, Lisa Hooi, Guangyi Wang, Yanzhen He, Antitsa Dimitrova Stoycheva, Debasis Das, Mougang Hu, Jun Sun, Donald Ruhrmund, Leonid Beigelman, Scott D. Seiwert, Karl Kossen, Brad O. Buckman, Jianhua Huang, P. T. Ravi Rajagopalan
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
2-(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives as potential anti-HCV drugs targeting NS5B polymerase have been investigated. Their synthesis, HCV NS5B polymerase inhibition and replicon activity are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d69fbe4c653de9ca4152f58421e72cc
https://pubmed.ncbi.nlm.nih.gov/19502055
https://pubmed.ncbi.nlm.nih.gov/19502055
Autor:
Shawn Misialek, P. T. Ravi Rajagopalan, Karl Kossen, Guangyi Wang, Xiaomin Wu, Laiguo Zhang, Debasis Das, Lisa Hooi, Donald Ruhrmund, Scott D. Seiwert, Brad O. Buckman, Leonid Beigelman
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
3-(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives as potential anti-HCV drugs targeting NS5B polymerase have been investigated. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0839e538c66f81e14d0adfb051849f1
https://pubmed.ncbi.nlm.nih.gov/19497737
https://pubmed.ncbi.nlm.nih.gov/19497737