Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment

Autor: Kai Markus Schneider, Antje Mohs, Wenfang Gui, Eric J. C. Galvez, Lena Susanna Candels, Lisa Hoenicke, Uthayakumar Muthukumarasamy, Christian H. Holland, Carsten Elfers, Konrad Kilic, Carolin Victoria Schneider, Robert Schierwagen, Pavel Strnad, Theresa H. Wirtz, Hanns-Ulrich Marschall, Eicke Latz, Benjamin Lelouvier, Julio Saez-Rodriguez, Willem de Vos, Till Strowig, Jonel Trebicka, Christian Trautwein

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

Steatohepatitis is a chronic hepatic inflammation associated with increased risk of hepatocellular carcinoma progression. Here the authors show that intestinal dysbiosis in mice lacking the inflammasome sensor molecule NLRP6 aggravates steatohepatiti

Externí odkaz: https://doaj.org/article/824434bb81f14bacbea787007aaff67c

Safety and efficacy of prophylactic and therapeutic vaccine based on live-attenuated Listeria monocytogenes in hepatobiliary cancers

Autor: Inga Hochnadel, Lisa Hoenicke, Nataliia Petriv, Lavinia Neubert, Elena Reinhard, Tatjana Hirsch, Juan Carlos Lopez Alfonso, Huizhen Suo, Thomas Longerich, Robert Geffers, Ralf Lichtinghagen, Carlos Alberto Guzmán, Heiner Wedemeyer, Henrike Lenzen, Michael Peter Manns, Dunja Bruder, Tetyana Yevsa

Publikováno v: Oncogene. 41(14)

Primary liver cancer (PLC) comprising hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) represents the third deadliest cancer worldwide with still insufficient treatment options. We have previously found that CD4 T helper 1 (Th1) response i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516e3c0e362193cc0b823076685aba0f
https://pubmed.ncbi.nlm.nih.gov/35418693

Microbiota-dependent expansion of testicular IL-17-producing Vγ6

Autor: Anneke, Wilharm, Helena C, Brigas, Inga, Sandrock, Miguel, Ribeiro, Tiago, Amado, Annika, Reinhardt, Abdi, Demera, Lisa, Hoenicke, Till, Strowig, Tânia, Carvalho, Immo, Prinz, Julie C, Ribot

Publikováno v: Mucosal Immunol

γδT cells represent the majority of lymphocytes in several mucosal tissues where they contribute to tissue homoeostasis, microbial defence and wound repair. Here we characterise a population of interleukin (IL) 17-producing γδ (γδ17) T cells th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::93ba2293bd01dc9d84aa556646cd99e7
https://pubmed.ncbi.nlm.nih.gov/32994549

Necroptosis microenvironment directs lineage commitment in liver cancer

Autor: Rishabh Chawla, Lisa Hoenicke, Nir Rozenblum, Jule Harbig, Johannes Zuber, Marco Seehawer, Gregory J. Dore, Hien Dang, Pierre-François Roux, Florian Heinzmann, Mihael Vucur, Thomas Longerich, Tom Luedde, Bence Sipos, Oliver Bischof, Tae-Won Kang, Xin Wei Wang, Lucas Robinson, Mathias Heikenwalder, Sabrina Klotz, Mareike Roth, Thorsten Buch, Luana D’Artista, Lars Zender

Publikováno v: Nature
Nature, Nature Publishing Group, 2018, 562 (7725), pp.69-75. ⟨10.1038/s41586-018-0519-y⟩
Nature, 2018, 562 (7725), pp.69-75. ⟨10.1038/s41586-018-0519-y⟩

Comment in :- Neighbourhood deaths cause a switch in cancer subtype. [Nature. 2018]- Neighbourly deaths dictate fate. [Nat Rev Cancer. 2018]- Bad neighborhoods: apoptotic and necroptotic microenvironments determine liver cancer subtypes. [Hepatobilia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02caf225f5c633bfb7fa5ddb2d717963

A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer

Autor: Nisar P. Malek, Anja Hohmeyer, Antti Poso, Thomas Longerich, Ramona Rudalska, Przemyslaw Bozko, Daniel Dauch, Giacomo Cossa, Martin Eilers, Sandrine Imbeaud, Tatu Pantsar, Lisa Hoenicke, Lars Zender, Torsten Wuestefeld, Tae-Won Kang, Jean-Charles Nault, Stefan Laufer, Tetyana Yevsa, Jessica Zucman-Rossi

Publikováno v: Nature Medicine

MYC oncoproteins are involved in the genesis and maintenance of the majority of human tumors but are considered undruggable. By using a direct in vivo shRNA screen, we show that liver cancer cells that have mutations in the gene encoding the tumor su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8763ef3c08db2955c7042f9b49a82b1d