Výsledky vyhledávání - "Lisa Hoelting"

Examination of microcystin neurotoxicity using central and peripheral human neurons

Autor: Stefanie, Klima, Ilinca, Suciu, Lisa, Hoelting, Simon, Gutbier, Tanja, Waldmann, Daniel R, Dietrich, Marcel, Leist

Microcystins (MC) are a group of cyanobacterial toxins that comprises MC-LF and other cyclic heptapeptides, best known as potent hepatotoxicants. Cell culture and epidemiological studies suggest that MC might also affect the nervous system, when ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::37284b95a487315070e65ee4f3fe2646

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Predicting Metabolism-Related Drug-Drug Interactions Using a Microphysiological Multitissue System

Autor: Andreas Hierlemann, Flavio Bonanini, Olivier Frey, Lisa Hoelting, Christian Lohasz, Kasper Renggli

Publikováno v: Advanced biosystems. 4(11)

Drug-drug interactions (DDIs) occur when the pharmacological activity of one drug is altered by a second drug. As multimorbidity and polypharmacotherapy are becoming more common due to the increasing age of the population, the risk of DDIs is massive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1cfc98c4c77d1d25838fc0c75d0246
https://pubmed.ncbi.nlm.nih.gov/33073544

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Corrigendum to A high-throughput approach to identify specific neurotoxicants / developmental toxicants in human neuronal cell function assays

Autor: Manuel Pastor, Raymond R. Tice, Lisa Hoelting, Marcel Leist, Simon Gutbier, Stefanie Klima, Falk Schreiber, Karsten Klein, Kevin Pinto-Gil, Jui-Hua Hsieh, Johannes Delp, Michael Aichem, Mamta Behl

Publikováno v: ALTEX. 36(3)

In this manuscript, which appeared in ALTEX 35 , 235-253 ( doi:10.14573/altex.1712182 ), the Acknowledgements should read: This work was supported by the Land BW, the Doerenkamp-Zbinden Foundation, the DFG (RTG1331, KoRS-CB), the BMBF (NeuriTox), and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70db9403aa55fd78fe33743b1309bc1e
https://pubmed.ncbi.nlm.nih.gov/29423527

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Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants

Autor: Britta Striegl, Marcel Leist, Alexander Bürkle, Michael Edelmann, Christian Adlhart, Cordula Hirsch, Stefan Schildknecht, Khalifah A. Salmeia, Stephanie Mathes, Lisa Hoelting, Johanna Nyffeler, Peter Wick, Alice Krebs, Regina Pape, Sabyasachi Gaan, Epifania Bono

Publikováno v: Archives of Toxicology

Halogen-free organophosphorus flame retardants are considered as replacements for the phased-out class of polybrominated diphenyl ethers (PBDEs). However, toxicological information on new flame retardants is still limited. Based on their excellent fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4362b907b5f9c153a519474d48d0e0
https://doi.org/10.1007/s00204-016-1680-4

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A high-throughput approach to identify specific neurotoxicants/ developmental toxicants in human neuronal cell function assays

Autor: Johannes, Delp, Simon, Gutbier, Stefanie, Klima, Lisa, Hoelting, Kevin, Pinto-Gil, Jui-Hua, Hsieh, Michael, Aichem, Karsten, Klein, Falk, Schreiber, Raymond R, Tice, Manuel, Pastor, Mamta, Behl, Marcel, Leist

Publikováno v: ALTEX. 35(2)

The (developmental) neurotoxicity hazard is still unknown for most chemicals. Establishing a test battery covering most of the relevant adverse outcome pathways may close this gap, without requiring a huge animal experimentation program. Ideally, eac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e598043ed6f6e8fb3d4e784988a03359
https://pubmed.ncbi.nlm.nih.gov/31329253

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A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

Autor: Nina V. Balmer, Julia Liebing, Regina Stöber, Marianna Grinberg, Stefan Schildknecht, Lisa Hoelting, Vaibhav Shinde, Eugen Rempel, Nils Blüthgen, Marcel Leist, Tanja Waldmann, Christoph van Thriel, John Antonydas Gaspar, Agapios Sachinidis, Jan G. Hengstler, Rosemarie Marchan, Jörg Rahnenführer, Johannes Meisig

Publikováno v: Archives of toxicology, 89(9): 1599–1618
Archives of Toxicology

Test systems to identify developmental toxicants are urgently needed. A combination of human stem cell technology and transcriptome analysis was to provide a proof of concept that toxicants with a related mode of action can be identified and grouped

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ffebe4abc3c7643174833bb49c1c8c
https://doi.org/10.1007/s00204-015-1573-y

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A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles

Autor: Olesja Bondarenko, Stefan Schildknecht, Stefan Mecking, Vivek Tanavde, Qian Yi Lee, Suzanne Kadereit, Marion Kapitza, Betty Tan, Marcel Leist, Benjamin Scheinhardt, Lisa Hoelting

Publikováno v: Archives of Toxicology; Vol 87
Archives of Toxicology

Nanoparticles (NPs) have been shown to accumulate in organs, cross the blood–brain barrier and placenta, and have the potential to elicit developmental neurotoxicity (DNT). Here, we developed a human embryonic stem cell (hESC)-derived 3-dimensional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222cd5fd2702bbaf0869a264f1f0a1de
https://doi.org/10.1007/s00204-012-0984-2

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