KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients

Autor: Lisa Hinz, Joan Torrella Barrufet, Vivi M. Heine

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-6 (2019)

Abstract Rett Syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG binding protein 2 (MECP2) gene. Deficient K+-Cl—co-transporter 2 (KCC2) expression is suggested to play a key role in the neurodevelopmental delay i

Externí odkaz: https://doaj.org/article/fbc3e17cf35b47409dd51bf3b1a3867f

Multiple Sclerosis Patient-Specific Primary Neurons Differentiated from Urinary Renal Epithelial Cells via Induced Pluripotent Stem Cells.

Autor: Megan G Massa, Barbara Gisevius, Sarah Hirschberg, Lisa Hinz, Matthias Schmidt, Ralf Gold, Nora Prochnow, Aiden Haghikia

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0155274 (2016)

As multiple sclerosis research progresses, it is pertinent to continue to develop suitable paradigms to allow for ever more sophisticated investigations. Animal models of multiple sclerosis, despite their continuing contributions to the field, may no

Externí odkaz: https://doaj.org/article/5210a1c8606947c980b56b374f8f9167

Generation of Isogenic Controls for In Vitro Disease Modelling of X-Chromosomal Disorders

Autor: Kyoko Watanabe, Lisa Hinz, Danielle Posthuma, Stephanie D. Hoekstra, Vivi M. Heine

Publikováno v: Stem Cell Reviews
Hinz, L, Hoekstra, S D, Watanabe, K, Posthuma, D & Heine, V M 2019, ' Generation of Isogenic Controls for In Vitro Disease Modelling of X-Chromosomal Disorders ', Stem Cell Reviews and Reports, vol. 15, no. 2, pp. 276-285 . https://doi.org/10.1007/s12015-018-9851-8
Hinz, L, Hoekstra, S D, Watanabe, K, Posthuma, D & Heine, V M 2019, ' Generation of Isogenic Controls for In Vitro Disease Modelling of X-Chromosomal Disorders ', Stem cell reviews and reports, vol. 15, no. 2, pp. 276-285 . https://doi.org/10.1007/s12015-018-9851-8
Stem Cell Reviews and Reports, 15(2), 276-285. Humana Press
Stem cell reviews and reports, 15(2), 276-285. Humana Press

Generation of proper controls is crucial in induced pluripotent stem cell (iPSC) studies. X-chromosomal disorders offer the potential to develop isogenic controls due to random X-chromosomal inactivation (XCI). However, the generation of such lines i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af961348e6fb5cffbef534d59d0948fe
https://doi.org/10.1007/s12015-018-9851-8

Patterning factors during neural progenitor induction determine regional identity and differentiation potential in vitro

Autor: Dwayne Holmes, Lisa Gasparotto, Paulien Cornelissen-Steijger, Vivi M. Heine, Prisca S. Leferink, Aishwarya G. Nadadhur, Lisa Hinz

Publikováno v: Stem Cell Research, 32, 25-34. Elsevier
Nadadhur, A G, Leferink, P S, Holmes, D, Hinz, L, Cornelissen-Steijger, P, Gasparotto, L & Heine, V M 2018, ' Patterning factors during neural progenitor induction determine regional identity and differentiation potential in vitro ', Stem Cell Research, vol. 32, pp. 25-34 . https://doi.org/10.1016/j.scr.2018.08.017
Stem Cell Research, Vol 32, Iss, Pp 25-34 (2018)

The neural tube consists of neural progenitors (NPs) that acquire different characteristics during gestation due to patterning factors. However, the influence of such patterning factors on human pluripotent stem cells (hPSCs) during in vitro neural d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06aa0074d97b012efbb9d2440f9483db
https://doi.org/10.1016/j.scr.2018.08.017

The first 15 min in art therapy: Painting a picture from the past

Autor: Lisa Hinz, Suzanne Haeyen

Publikováno v: The Arts in Psychotherapy, 71(101718)
The Arts in Psychotherapy, 71

Many affective experiences and learning processes including attachment patterns from early developmental phases manifest during psychotherapy. The first 15 min in art therapy can potentially reveal clients’ preferred ways of processing information

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6717072908f56704dbf1527ab0a5e265
https://doi.org/10.1016/j.aip.2020.101718