Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Lisa H. Gold"'
Publikováno v:
Neurobiology of Disease, Vol 4, Iss 3, Pp 265-274 (1997)
In addition to its profound effects on the immune system, HIV also infects the CNS and can cause abnormalities in infected individuals ranging from mild cognitive and motor disorders to frank dementia. We have been actively investigating the molecula
Externí odkaz:
https://doaj.org/article/8eaeef3c135944e2a58063b01193624f
Autor:
Patricia E. Cole, Dawn C. Matthews, Klaus Romero, Danny Chen, Zhiyong Xie, Robin Wolz, Daniela J. Conrado, Timothy Nicholas, Vikram Sinha, Wenping Wang, Brian A. Willis, Derek L. G. Hill, James Hendrix, Volker D. Kern, Julie A. Stone, Lisa H. Gold, Jackson Burton, Stephen P. Arneric, Mark Forrest Gordon, Gerald Novak
Publikováno v:
Alzheimer's & Dementia. 14
Autor:
Stephen P. Arneric, Lisa H. Gold, Klaus Romero, Stacie Weninger, Volker D. Kern, Martha Brumfield, Billy Dunn, Maria C. Carrillo
Publikováno v:
Alzheimer's & Dementia. 14
Autor:
Jeffrey E. Campbell, Robin Roof, Peter A. Boxer, Johnson Paul D, Ann M. Janssen, Jamie Singer, Jacob Bradley Schwarz, Nicole S. Roush, Leonard T. Meltzer, Chad L. Stoner, Michael William Wilson, Lisa H. Gold, Shelley R. Graham, Susan Hurst, Ti-Zhi Su, Leonard W. Cooke
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2409-2412
The synthesis and SAR of tolylamines with 5-HT6 receptor antagonist activity is presented. The amine, core aromatic, peripheral aromatic, and ether linker moieties of HTS hit 1 were modulated and the effect on potency at 5-HT6 examined. Tolylpiperidi
Publikováno v:
Neuroscience Letters. 367:164-167
Reports suggest that Alzheimer's disease (AD) patients show a high life-time prevalence of seizure-like disorders. The transgenic CRND8 (TgCRDN8) is a mouse model of AD-like amyloid pathogenesis that expresses a double-mutant form of human amyloid pr
Publikováno v:
European Journal of Pharmacology. 499:135-146
The development of selective corticotropin-releasing factor type-1 (CRF1) receptor antagonists represents a potential novel treatment for depression. These studies evaluated CRF1 receptor antagonists for antidepressant-like activity in mice. Subchron
Publikováno v:
Drug and Alcohol Dependence. 70:S73-S85
Evaluation of abuse liability is one of many obligations incurred by industrial sponsors in the development of medications acting on substrates in the central nervous system. In addition to providing the information necessary for a scheduling recomme
Autor:
Amanda J. Roberts, Lisa H. Gold, Ilham Polis, Jeffrey S. McDonald, Dominique Filliol, Brigitte L. Kieffer, George F. Koob
Publikováno v:
Alcoholism: Clinical and Experimental Research. 25:1249-1256
Autor:
George F. Koob, Lisa H. Gold, Amanda J. Roberts, Ilham Polis, Brigitte L. Kieffer, Dominique Filliol, Jeffrey S. McDonald
Publikováno v:
Alcoholism: Clinical and Experimental Research. 25:1249-1256
Background The role of the delta-opioid receptor in ethanol drinking has remained unclear despite the use of traditional pharmacological and correlational approaches. The results of several studies suggest that pharmacological blockade of these recep
Autor:
Michael R. Weed, Loren H. Parsons, Salvador Huitron-Resendiz, Richard Schroeder, Sophia A. Davis, Steven J. Henriksen, Michael A. Taffe, Lisa H. Gold
Publikováno v:
Neuropsychopharmacology. 24:230-239
Six rhesus monkeys were trained to stable performance on neuropsychological tests of memory, reinforcer efficacy, reaction time and bimanual motor coordination. Three monkeys were then exposed to a high-dose, short course regimen of (+/-)3,4-Methylen