Preinduced reovirus-specific T-cell immunity enhances the anticancer efficacy of reovirus therapy

Autor: Rob C Hoeben, Sjoerd H van der Burg, Marjolein Sluijter, Thorbald van Hall, Joke M M Den Haan, Camilla Labrie, Christianne Groeneveldt, Priscilla Kinderman, Diana J M van den Wollenberg, Nadine van Montfoort, Lisa Griffioen, Jordi J C van Stigt Thans

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)

Background Many solid tumors do not respond to immunotherapy due to their immunologically cold tumor microenvironment (TME). We and others found that oncolytic viruses (OVs), including reovirus type 3 Dearing, can enhance the efficacy of immunotherap

Externí odkaz: https://doaj.org/article/3366d822d5c7405c92a4c4b02eb41013

Figure S2 from Intertumoral Differences Dictate the Outcome of TGF-β Blockade on the Efficacy of Viro-Immunotherapy

Autor: Nadine van Montfoort, Thorbald van Hall, Lukas J.A.C. Hawinkels, Peter ten Dijke, Sjoerd H. van der Burg, Rob C. Hoeben, Diana J.M. van den Wollenberg, Camilla Labrie, Lisa Griffioen, Marjolein Sluijter, Priscilla Kinderman, Jurriaan Q. van Ginkel, Christianne Groeneveldt

Figure S2. Late TGF-β blockade does not affect tumor outgrowth.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e34507c8eea49de6eff7fa381278f9
https://doi.org/10.1158/2767-9764.22546523

Data from Intertumoral Differences Dictate the Outcome of TGF-β Blockade on the Efficacy of Viro-Immunotherapy

Autor: Nadine van Montfoort, Thorbald van Hall, Lukas J.A.C. Hawinkels, Peter ten Dijke, Sjoerd H. van der Burg, Rob C. Hoeben, Diana J.M. van den Wollenberg, Camilla Labrie, Lisa Griffioen, Marjolein Sluijter, Priscilla Kinderman, Jurriaan Q. van Ginkel, Christianne Groeneveldt

The absence of T cells in the tumor microenvironment of solid tumors is a major barrier to cancer immunotherapy efficacy. Oncolytic viruses, including reovirus type 3 Dearing (Reo), can recruit CD8+ T cells to the tumor and thereby enhance the effica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a2a061c8382221c6d3d9021f749572
https://doi.org/10.1158/2767-9764.c.6551195

Preinduced reovirus-specific T-cell immunity enhances the anticancer efficacy of reovirus therapy

Autor: Christianne Groeneveldt, Priscilla Kinderman, Jordi J C van Stigt Thans, Camilla Labrie, Lisa Griffioen, Marjolein Sluijter, Diana J M van den Wollenberg, Rob C Hoeben, Joke M M den Haan, Sjoerd H van der Burg, Thorbald van Hall, Nadine van Montfoort

Publikováno v: None
Groeneveldt, C, Kinderman, P, van Stigt Thans, J J C, Labrie, C, Griffioen, L, Sluijter, M, van den Wollenberg, D J M, Hoeben, R C, den Haan, J M M, van der Burg, S H, van Hall, T & van Montfoort, N 2022, ' Preinduced reovirus-specific T-cell immunity enhances the anticancer efficacy of reovirus therapy ', Journal for Immunotherapy of Cancer, vol. 10, no. 7, e004464 . https://doi.org/10.1136/jitc-2021-004464
Journal for Immunotherapy of Cancer, 10(7):e004464. BioMed Central

BackgroundMany solid tumors do not respond to immunotherapy due to their immunologically cold tumor microenvironment (TME). We and others found that oncolytic viruses (OVs), including reovirus type 3 Dearing, can enhance the efficacy of immunotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c67010144e07f4349f04d13ac4d7a54
http://hdl.handle.net/1887/3492252

Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S

Autor: Tom J Harryvan, Marten Visser, Linda de Bruin, Léonie Plug, Lisa Griffioen, Arend Mulder, Peter A van Veelen, Gerbrand J van der Heden van Noort, Marlieke LM Jongsma, Miranda H Meeuwsen, Emmanuel JHJ Wiertz, Saskia J Santegoets, James CH Hardwick, Thorbald Van Hall, Jacques Neefjes, Sjoerd H Van der Burg, Lukas JAC Hawinkels, Els ME Verdegaal

Publikováno v: Journal for ImmunoTherapy of Cancer, 10(3). BMJ PUBLISHING GROUP

BackgroundCross-presentation of exogenous antigens in HLA-class I molecules by professional antigen presenting cells (APCs) is crucial for CD8+ T cell function. Recent murine studies show that several non-professional APCs, including cancer-associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7882fe0538501e4791306fdd6a867d72
https://doi.org/10.1136/jitc-2021-003591