A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.

Autor: Sabine M Hölter, Mary Stromberg, Marina Kovalenko, Lillian Garrett, Lisa Glasl, Edith Lopez, Jolene Guide, Alexander Götz, Wolfgang Hans, Lore Becker, Birgit Rathkolb, Jan Rozman, Anja Schrewed, Martin Klingenspor, Thomas Klopstock, Holger Schulz, Eckhard Wolf, Wolfgang Wursta, Tammy Gillis, Hiroko Wakimoto, Jonathan Seidman, Marcy E MacDonald, Susan Cotman, Valérie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Jong-Min Lee, Vanessa C Wheeler

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e80923 (2013)

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of a CAG trinucleotide repeat in the HTT gene encoding huntingtin. The disease has an insidious course, typically progressing over 10-15 years until

Externí odkaz: https://doaj.org/article/57b263b8d55c4fe881fd6b6ee0978b4a

Analysis of locomotor behavior in the German Mouse Clinic

Autor: Jan Rozman, Valerie Gailus-Durner, Angelika Hummel, Annemarie Zimprich, Petra Dirscherl, Manuela A. Östereicher, Lisa Glasl, Florian Giesert, Martin Hrabě de Angelis, Wolfgang Wurst, Lillian Garrett, Lore Becker, Sabine M. Hölter, Helmut Fuchs, Luise Ernst, Daniela Vogt-Weisenhorn

Publikováno v: J. Neurosci. Methods, DOI: 10.1016/j.jneumeth.2017.05.005 (2017)
Journal of neuroscience methods 300, 77-91 (2018). doi:10.1016/j.jneumeth.2017.05.005

Background Generation and phenotyping of mutant mouse models continues to increase along with the search for the most efficient phenotyping tests. Here we asked if a combination of different locomotor tests is necessary for comprehensive locomotor ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1f6eeab9cf2a1484097ca00168df49
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=51095

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43

Autor: Lisa Glasl, Elisabeth Kremmer, Dietrich Trümbach, Thomas Klopstock, Jan Rozman, Aladin Samara, Martin Klingenspor, Sebastian Koob, Wolfgang Wurst, Martin Hrabě de Angelis, Frauke Neff, Carola Stribl, Eckhard Wolf, Birgit Rathkolb, Manuela Neumann, Regina Peis, Lore Becker, Thomas Floss, Helmut Fuchs, Axel Walch, Sabine M. Hölter, Valerie Gailus-Durner, Wolfgang Hans, Andreas S. Reichert, Michaela Aichler, Johannes Beckers, Marion Horsch

Publikováno v: The journal of biological chemistry 289(15), 10769-10784 (2014). doi:10.1074/jbc.M113.515940

The majority of amyotrophic lateral sclerosis (ALS) cases as well as many patients suffering from frontotemporal lobar dementia (FTLD) with ubiquitinated inclusion bodies show TDP-43 pathology, the protein encoded by the TAR DNA-binding protein (Tard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500a8183473a2d621752f3ef269a3edd
https://pubmed.ncbi.nlm.nih.gov/25215360

Innovations in phenotyping of mouse models in the German Mouse Clinic

Autor: Oliver Eickelberg, Hugo A. Katus, Oliver Puk, Minxuan Sun, Gabriele Möller, Dirk H. Busch, Eva Janas, Jack Favor, Melanie Kahle, Ralph Steinkamp, Wilfried Szymczak, Markus Ollert, Markus F. Scheerer, Susanne Neschen, Andreas Zimmer, Holger Maier, Thure Adler, Valerie Gailus-Durner, Jan Rozman, Ali Önder Yildirim, Claudia Stöger, Tonia Ludwig, Julia Calzada-Wack, Christoph Lengger, Martin Klingenspor, Anja Schrewe, Ingrid L. Vargas Panesso, Sabine M. Hölter, Evelyn Schiller, Monja Willershäuser, Luciana Caminha Afonso, Barbara Fridrich, Beatrix Naton, Michael Räß, Alexander Götz, Christian M. Cohrs, Eckhard Wolf, Jerzy Adamski, Martin Hrabě de Angelis, Anja Hurt, Ildiko Racz, Birgit Rathkolb, Alexander Bohla, Ramona Zeh, Thomas Klopstock, Tanja Klein-Rodewald, Lore Becker, Kateryna Micklich, Frauke Neff, Alexandra Vernaleken, Tobias Stöger, Annemarie Wolff-Muscate, Juan Antonio Aguilar-Pimentel, Dirk Janik, Wolfgang Hans, Cornelia Prehn, Raffi Bekeredjian, Wolfgang Wurst, Susan Marschall, Christoph Höschen, Helmut Fuchs, Heinz Höfler, Lisa Glasl, Lillian Garrett, Anna Dewert, Martin Kistler, Irina Treise, Jochen Graw, Holger Schulz, Johannes Beckers, Marion Horsch

Publikováno v: Mamm. Genome 23, 611-622 (2012)
Mammalian genome 23(9-10), 611-622 (2012). doi:10.1007/s00335-012-9415-1
Mammalian Genome

Under the label of the German Mouse Clinic (GMC), a concept has been developed and implemented that allows the better understanding of human diseases on the pathophysiological and molecular level. This includes better understanding of the crosstalk b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4c9113cf82c123a12ff3d46acda9d4
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=10697

Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb

Autor: Ralf Kühn, Ulrich Hafen, Martin Hrabé de Angelis, Andreas Hofmann, Karina Kloos, Daniela M. Vogt Weisenhorn, Julia Zerle, Lisa Glasl, Sabine M. Hölter, Konstanze F. Winklhofer, Florian Giesert, Anne Roethig, Jingzhong Zhang, Wolfgang Wurst, Barbara Di Benedetto

Publikováno v: Experimental neurology 235(1), 214-227 (2012). doi:10.1016/j.expneurol.2012.01.002

Parkinson's Disease (PD) is the most common neurodegenerative movement disorder. Autosomal-recessive mutations in the mitochondrial protein kinase PINK1 (PTEN-induced kinase 1) account for 1-2% of the hereditary early-onset cases. To study the mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f86d1881576dcab83bb1a0a9e5d001
https://pubmed.ncbi.nlm.nih.gov/22265660