Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models

Autor: Ilaria Dettori, Irene Fusco, Irene Bulli, Lisa Gaviano, Elisabetta Coppi, Federica Cherchi, Martina Venturini, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Alessio Nocentini, Claudiu T. Supuran, Anna Maria Pugliese, Felicita Pedata

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 964-976 (2021)

Ischaemic stroke is a leading cause of death and disability. One of the major pathogenic mechanisms after ischaemia includes the switch to the glycolytic pathway, leading to tissue acidification. Carbonic anhydrase (CA) contributes to pH regulation.

Externí odkaz: https://doaj.org/article/b71f43961f06497bbcb2ac3275cfbddc

A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Is Protective in a Rat Model of Transient Cerebral Ischemia

Autor: Ilaria Dettori, Lisa Gaviano, Alessia Melani, Laura Lucarini, Mariaconcetta Durante, Emanuela Masini, Felicita Pedata

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Cerebral ischemia is a multifactorial pathology characterized by different events evolving in time. The acute injury, characterized by excitoxicity, is followed by a secondary brain injury that develops from hours to days after ischemia. Extracellula

Externí odkaz: https://doaj.org/article/461c10c2b8e247d4b851c1af7f8fa7df

Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models

Autor: Irene Fusco, Martina Venturini, Felicita Pedata, Lorenzo Di Cesare Mannelli, Lisa Gaviano, Anna Maria Pugliese, Claudiu T. Supuran, Irene Bulli, Federica Cherchi, Carla Ghelardini, Ilaria Dettori, Alessio Nocentini, Elisabetta Coppi

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 964-976 (2021)

Ischaemic stroke is a leading cause of death and disability. One of the major pathogenic mechanisms after ischaemia includes the switch to the glycolytic pathway, leading to tissue acidification. Carbonic anhydrase (CA) contributes to pH regulation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b16c961b3e115d43cb24aab3d9c6e84
https://doaj.org/article/b71f43961f06497bbcb2ac3275cfbddc

Protective Effect of Adenosine A

Autor: Ilaria, Dettori, Lisa, Gaviano, Filippo, Ugolini, Daniele, Lana, Irene, Bulli, Giada, Magni, Francesca, Rossi, Maria Grazia, Giovannini, Felicita, Pedata

Publikováno v: Frontiers in Pharmacology

Cerebral ischemia is a multifactorial pathology characterized first by an acute injury, due to excitotoxicity, followed by a secondary brain injury that develops hours to days after ischemia. During ischemia, adenosine acts as an endogenous neuroprot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4afd361214e2e71ca3e57aebc0104c46
https://pubmed.ncbi.nlm.nih.gov/33643036

Adenosine A(2B) receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway

Autor: Francesca Cencetti, Chiara Donati, Flavia Varano, Ilaria Dettori, Anna Maria Pugliese, Federica Cherchi, Giada Magni, Vittoria Colotta, Francesca Rossi, Lisa Gaviano, Paola Bruni, Irene Fusco, Daniela Catarzi, Caterina Bernacchioni, Felicita Pedata, Elisabetta Coppi

Publikováno v: Biochemical pharmacology 177 (2020). doi:10.1016/j.bcp.2020.113956
info:cnr-pdr/source/autori:Coppi, Elisabetta; Cherchi, Federica; Fusco, Irene; Dettori, Ilaria; Gaviano, Lisa; Magni, Giada; Catarzi, Daniela; Colotta, Vittoria; Varano, Flavia; Rossi, Francesca; Bernacchioni, Caterina; Donati, Chiara; Bruni, Paola; Pedata, Felicita; Cencetti, Francesca; Pugliese, Anna Maria/titolo:Adenosine A(2B) receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway/doi:10.1016%2Fj.bcp.2020.113956/rivista:Biochemical pharmacology/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:177

Oligodendrocytes are the only myelinating cells in the brain and differentiate from their progenitors (OPCs) throughout adult life. However, this process fails in demyelinating pathologies. Adenosine is emerging as an important player in OPC differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5410e47369a291ba96a6674283873bc
https://publications.cnr.it/doc/439660